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Efficacy of butylphthalide in preventing cognitive decline in ischaemic stroke survivors: a 12-month prospective following-up study

Qingqing Han, Xiyu Zhao, Yingzhe Shao, Fengtao Tan, Haotian Wen, Di Wang, Xiao Li, Yunfan Wang, Jun Tu, Lifeng Wang, Xianjia Ning, Jinghua Wang, Yan Li
DOI: 10.1136/svn-2024-003611 Published 25 January 2025
Qingqing Han
1Jizhou Clinical College, Tianjin Medical University, Tianjin, China
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Xiyu Zhao
2Department of Critical Care Medicine, Tianjin Jizhou People’s Hospital, Tianjin, People's Republic of China
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Yingzhe Shao
3Department of Neurology, Tianjin Medical University General Hospital, Tianjin, Tianjin, China
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Fengtao Tan
3Department of Neurology, Tianjin Medical University General Hospital, Tianjin, Tianjin, China
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Haotian Wen
4The First Clinical School, Southern Medical University, Guangzhou, Guangdong, China
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Di Wang
5College of Anesthesiology, Shanxi Medical University, Taiyuan, Shanxi, China
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Xiao Li
3Department of Neurology, Tianjin Medical University General Hospital, Tianjin, Tianjin, China
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Yunfan Wang
3Department of Neurology, Tianjin Medical University General Hospital, Tianjin, Tianjin, China
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Jun Tu
3Department of Neurology, Tianjin Medical University General Hospital, Tianjin, Tianjin, China
6Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China
7Laboratory of Epidemiology, Tianjin Neurological Institute, Tianjin, China
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Lifeng Wang
1Jizhou Clinical College, Tianjin Medical University, Tianjin, China
8Institute of Clinical Epidemiology & Evidence-Based Medicine, Tianjin Jizhou People's Hospital, Tianjin, China
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Xianjia Ning
7Laboratory of Epidemiology, Tianjin Neurological Institute, Tianjin, China
8Institute of Clinical Epidemiology & Evidence-Based Medicine, Tianjin Jizhou People's Hospital, Tianjin, China
9Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin Neurological Institute, Tianjin, People's Republic of China
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Jinghua Wang
7Laboratory of Epidemiology, Tianjin Neurological Institute, Tianjin, China
8Institute of Clinical Epidemiology & Evidence-Based Medicine, Tianjin Jizhou People's Hospital, Tianjin, China
9Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin Neurological Institute, Tianjin, People's Republic of China
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Yan Li
1Jizhou Clinical College, Tianjin Medical University, Tianjin, China
8Institute of Clinical Epidemiology & Evidence-Based Medicine, Tianjin Jizhou People's Hospital, Tianjin, China
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Article Information

DOI 
https://doi.org/10.1136/svn-2024-003611
PubMed 
39863299

Print ISSN 
2059-8688
Online ISSN 
2059-8696
History 
  • Received August 7, 2024
  • Accepted January 12, 2025
  • Published online January 25, 2025.

Copyright & Usage 
© Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

Author Information

  1. Qingqing Han1,
  2. Xiyu Zhao2,
  3. Yingzhe Shao3,
  4. Fengtao Tan3,
  5. Haotian Wen4,
  6. Di Wang5,
  7. Xiao Li3,
  8. Yunfan Wang3,
  9. Jun Tu3,6,7,
  10. Lifeng Wang1,8,
  11. Xianjia Ning7,8,9,
  12. Jinghua Wang7,8,9,
  13. Yan Li1,8
  1. 1Jizhou Clinical College, Tianjin Medical University, Tianjin, China
  2. 2Department of Critical Care Medicine, Tianjin Jizhou People’s Hospital, Tianjin, People's Republic of China
  3. 3Department of Neurology, Tianjin Medical University General Hospital, Tianjin, Tianjin, China
  4. 4The First Clinical School, Southern Medical University, Guangzhou, Guangdong, China
  5. 5College of Anesthesiology, Shanxi Medical University, Taiyuan, Shanxi, China
  6. 6Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China
  7. 7Laboratory of Epidemiology, Tianjin Neurological Institute, Tianjin, China
  8. 8Institute of Clinical Epidemiology & Evidence-Based Medicine, Tianjin Jizhou People's Hospital, Tianjin, China
  9. 9Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin Neurological Institute, Tianjin, People's Republic of China
  1. Correspondence to Professor Yan Li; liyanmanu{at}163.com; Professor Xianjia Ning; xning{at}tmu.edu.cn; Professor Jinghua Wang; jwang3{at}tmu.edu.cn
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Efficacy of butylphthalide in preventing cognitive decline in ischaemic stroke survivors: a 12-month prospective following-up study
Qingqing Han, Xiyu Zhao, Yingzhe Shao, Fengtao Tan, Haotian Wen, Di Wang, Xiao Li, Yunfan Wang, Jun Tu, Lifeng Wang, Xianjia Ning, Jinghua Wang, Yan Li
Stroke and Vascular Neurology Jan 2025, svn-2024-003611; DOI: 10.1136/svn-2024-003611

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Efficacy of butylphthalide in preventing cognitive decline in ischaemic stroke survivors: a 12-month prospective following-up study
Qingqing Han, Xiyu Zhao, Yingzhe Shao, Fengtao Tan, Haotian Wen, Di Wang, Xiao Li, Yunfan Wang, Jun Tu, Lifeng Wang, Xianjia Ning, Jinghua Wang, Yan Li
Stroke and Vascular Neurology Jan 2025, svn-2024-003611; DOI: 10.1136/svn-2024-003611
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Efficacy of butylphthalide in preventing cognitive decline in ischaemic stroke survivors: a 12-month prospective following-up study
Qingqing Han, Xiyu Zhao, Yingzhe Shao, Fengtao Tan, Haotian Wen, Di Wang, Xiao Li, Yunfan Wang, Jun Tu, Lifeng Wang, Xianjia Ning, Jinghua Wang, Yan Li
Stroke and Vascular Neurology Jan 2025, svn-2024-003611; DOI: 10.1136/svn-2024-003611
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