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Rationale and Study Design to Assess the Efficacy and Safety of Minocycline in Patients with Moderate to Severe Acute Ischaemic Stroke (EMPHASIS)

Yao Lu, Ling Guan, Meiyang Zhang, Qianqian Yang, Baoshan Qiu, Dongyang Zhou, Yicong Wang, Yuesong Pan, Luyan Wang, Xuejiao Zhou, Hui Qu, Xiaoling Liao, Liping Liu, Xingquan Zhao, Philip M Bath, S Claiborne Johnston, Pierre Amarenco, Yongjun Wang, Yilong Wang
DOI: 10.1136/svn-2024-003577 Published 26 March 2025
Yao Lu
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Ling Guan
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2The University of British Columbia Department of Medicine, Vancouver, British Columbia, Canada
3China National Clinical Research Center for Neurological Diseases, Beijing, China
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Meiyang Zhang
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Qianqian Yang
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Baoshan Qiu
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
4Chinese Institute for Brain Research, Beijing, China
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Dongyang Zhou
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
5Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
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Yicong Wang
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Yuesong Pan
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
3China National Clinical Research Center for Neurological Diseases, Beijing, China
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Luyan Wang
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
3China National Clinical Research Center for Neurological Diseases, Beijing, China
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Xuejiao Zhou
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Hui Qu
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
3China National Clinical Research Center for Neurological Diseases, Beijing, China
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Xiaoling Liao
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
3China National Clinical Research Center for Neurological Diseases, Beijing, China
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Liping Liu
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
3China National Clinical Research Center for Neurological Diseases, Beijing, China
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Xingquan Zhao
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
3China National Clinical Research Center for Neurological Diseases, Beijing, China
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Philip M Bath
6Stroke Trials Unit, Mental Health & Clinical Neuroscience, University of Nottingham, Nottingham, UK
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S Claiborne Johnston
7Dell Medical School, The University of Texas at Austin, Austin, Texas, USA
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Pierre Amarenco
8Department of Neurology and Stroke Center, University Paris Cite, Paris, France
9Population Health Research Institute, McMaster University, Hamilton, New Zealand, Canada
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Yongjun Wang
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
3China National Clinical Research Center for Neurological Diseases, Beijing, China
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Yilong Wang
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
3China National Clinical Research Center for Neurological Diseases, Beijing, China
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Rationale and Study Design to Assess the Efficacy and Safety of Minocycline in Patients with Moderate to Severe Acute Ischaemic Stroke (EMPHASIS)
Yao Lu, Ling Guan, Meiyang Zhang, Qianqian Yang, Baoshan Qiu, Dongyang Zhou, Yicong Wang, Yuesong Pan, Luyan Wang, Xuejiao Zhou, Hui Qu, Xiaoling Liao, Liping Liu, Xingquan Zhao, Philip M Bath, S Claiborne Johnston, Pierre Amarenco, Yongjun Wang, Yilong Wang
Stroke and Vascular Neurology Mar 2025, svn-2024-003577; DOI: 10.1136/svn-2024-003577

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Rationale and Study Design to Assess the Efficacy and Safety of Minocycline in Patients with Moderate to Severe Acute Ischaemic Stroke (EMPHASIS)
Yao Lu, Ling Guan, Meiyang Zhang, Qianqian Yang, Baoshan Qiu, Dongyang Zhou, Yicong Wang, Yuesong Pan, Luyan Wang, Xuejiao Zhou, Hui Qu, Xiaoling Liao, Liping Liu, Xingquan Zhao, Philip M Bath, S Claiborne Johnston, Pierre Amarenco, Yongjun Wang, Yilong Wang
Stroke and Vascular Neurology Mar 2025, svn-2024-003577; DOI: 10.1136/svn-2024-003577
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Rationale and Study Design to Assess the Efficacy and Safety of Minocycline in Patients with Moderate to Severe Acute Ischaemic Stroke (EMPHASIS)
Yao Lu, Ling Guan, Meiyang Zhang, Qianqian Yang, Baoshan Qiu, Dongyang Zhou, Yicong Wang, Yuesong Pan, Luyan Wang, Xuejiao Zhou, Hui Qu, Xiaoling Liao, Liping Liu, Xingquan Zhao, Philip M Bath, S Claiborne Johnston, Pierre Amarenco, Yongjun Wang, Yilong Wang
Stroke and Vascular Neurology Mar 2025, svn-2024-003577; DOI: 10.1136/svn-2024-003577
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