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Open Access

Rationale and Study Design to Assess the Efficacy and Safety of Minocycline in Patients with Moderate to Severe Acute Ischaemic Stroke (EMPHASIS)

Yao Lu, Ling Guan, Meiyang Zhang, Qianqian Yang, Baoshan Qiu, Dongyang Zhou, Yicong Wang, Yuesong Pan, Luyan Wang, Xuejiao Zhou, Hui Qu, Xiaoling Liao, Liping Liu, Xingquan Zhao, Philip M Bath, S Claiborne Johnston, Pierre Amarenco, Yongjun Wang, Yilong Wang
DOI: 10.1136/svn-2024-003577 Published 26 March 2025
Yao Lu
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Ling Guan
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2The University of British Columbia Department of Medicine, Vancouver, British Columbia, Canada
3China National Clinical Research Center for Neurological Diseases, Beijing, China
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Meiyang Zhang
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Qianqian Yang
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Baoshan Qiu
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
4Chinese Institute for Brain Research, Beijing, China
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Dongyang Zhou
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
5Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
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Yicong Wang
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Yuesong Pan
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
3China National Clinical Research Center for Neurological Diseases, Beijing, China
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Luyan Wang
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
3China National Clinical Research Center for Neurological Diseases, Beijing, China
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Xuejiao Zhou
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Hui Qu
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
3China National Clinical Research Center for Neurological Diseases, Beijing, China
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Xiaoling Liao
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
3China National Clinical Research Center for Neurological Diseases, Beijing, China
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Liping Liu
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
3China National Clinical Research Center for Neurological Diseases, Beijing, China
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Xingquan Zhao
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
3China National Clinical Research Center for Neurological Diseases, Beijing, China
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Philip M Bath
6Stroke Trials Unit, Mental Health & Clinical Neuroscience, University of Nottingham, Nottingham, UK
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S Claiborne Johnston
7Dell Medical School, The University of Texas at Austin, Austin, Texas, USA
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Pierre Amarenco
8Department of Neurology and Stroke Center, University Paris Cite, Paris, France
9Population Health Research Institute, McMaster University, Hamilton, New Zealand, Canada
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Yongjun Wang
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
3China National Clinical Research Center for Neurological Diseases, Beijing, China
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Yilong Wang
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
3China National Clinical Research Center for Neurological Diseases, Beijing, China
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Article Information

DOI 
https://doi.org/10.1136/svn-2024-003577
PubMed 
40147820

Print ISSN 
2059-8688
Online ISSN 
2059-8696
History 
  • Received July 25, 2024
  • Accepted November 21, 2024
  • Published online March 26, 2025.

Copyright & Usage 
© Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

Author Information

  1. Yao Lu1,
  2. Ling Guan1,2,3,
  3. Meiyang Zhang1,
  4. Qianqian Yang1,
  5. Baoshan Qiu1,4,
  6. Dongyang Zhou1,5,
  7. Yicong Wang1,
  8. Yuesong Pan1,3,
  9. Luyan Wang1,3,
  10. Xuejiao Zhou1,
  11. Hui Qu1,3,
  12. Xiaoling Liao1,3,
  13. Liping Liu1,3,
  14. Xingquan Zhao1,3,
  15. Philip M Bath6,
  16. S Claiborne Johnston7,
  17. Pierre Amarenco8,9,
  18. Yongjun Wang1,3,
  19. Yilong Wang1,3
  1. 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
  2. 2The University of British Columbia Department of Medicine, Vancouver, British Columbia, Canada
  3. 3China National Clinical Research Center for Neurological Diseases, Beijing, China
  4. 4Chinese Institute for Brain Research, Beijing, China
  5. 5Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
  6. 6Stroke Trials Unit, Mental Health & Clinical Neuroscience, University of Nottingham, Nottingham, UK
  7. 7Dell Medical School, The University of Texas at Austin, Austin, Texas, USA
  8. 8Department of Neurology and Stroke Center, University Paris Cite, Paris, France
  9. 9Population Health Research Institute, McMaster University, Hamilton, New Zealand, Canada
  1. Correspondence to Professor Yilong Wang; yilong528{at}aliyun.com
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Rationale and Study Design to Assess the Efficacy and Safety of Minocycline in Patients with Moderate to Severe Acute Ischaemic Stroke (EMPHASIS)
Yao Lu, Ling Guan, Meiyang Zhang, Qianqian Yang, Baoshan Qiu, Dongyang Zhou, Yicong Wang, Yuesong Pan, Luyan Wang, Xuejiao Zhou, Hui Qu, Xiaoling Liao, Liping Liu, Xingquan Zhao, Philip M Bath, S Claiborne Johnston, Pierre Amarenco, Yongjun Wang, Yilong Wang
Stroke and Vascular Neurology Mar 2025, svn-2024-003577; DOI: 10.1136/svn-2024-003577

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Rationale and Study Design to Assess the Efficacy and Safety of Minocycline in Patients with Moderate to Severe Acute Ischaemic Stroke (EMPHASIS)
Yao Lu, Ling Guan, Meiyang Zhang, Qianqian Yang, Baoshan Qiu, Dongyang Zhou, Yicong Wang, Yuesong Pan, Luyan Wang, Xuejiao Zhou, Hui Qu, Xiaoling Liao, Liping Liu, Xingquan Zhao, Philip M Bath, S Claiborne Johnston, Pierre Amarenco, Yongjun Wang, Yilong Wang
Stroke and Vascular Neurology Mar 2025, svn-2024-003577; DOI: 10.1136/svn-2024-003577
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Rationale and Study Design to Assess the Efficacy and Safety of Minocycline in Patients with Moderate to Severe Acute Ischaemic Stroke (EMPHASIS)
Yao Lu, Ling Guan, Meiyang Zhang, Qianqian Yang, Baoshan Qiu, Dongyang Zhou, Yicong Wang, Yuesong Pan, Luyan Wang, Xuejiao Zhou, Hui Qu, Xiaoling Liao, Liping Liu, Xingquan Zhao, Philip M Bath, S Claiborne Johnston, Pierre Amarenco, Yongjun Wang, Yilong Wang
Stroke and Vascular Neurology Mar 2025, svn-2024-003577; DOI: 10.1136/svn-2024-003577
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