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Prevalence, genetic and clinical characteristics in first-degree relatives of patients with familial cerebral cavernous malformations in China

Chunwang Li, Lingyun Zhuo, Yaqing Kang, Penghui Liu, Weilin Huang, Qixuan Li, Ke Ma, Shuna Huang, Xinru Lin, Weiheng Zhuang, Haojie Wang, Darong Chen, Huimin Wang, Qiu He, Zhuyu Gao, Xuegang Niu, Yajun Jing, Lingjun Yan, Bin Gao, Dengliang Wang, Shaowei Lin, Siying Wu, Yuanxiang Lin, Dezhi Kang, Fuxin Lin
DOI: 10.1136/svn-2023-003004 Published 15 May 2024
Chunwang Li
1Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
2Department of Neurosurgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, Fujian, China
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Lingyun Zhuo
1Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
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Yaqing Kang
3Department of Radiology, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
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Penghui Liu
1Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
2Department of Neurosurgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, Fujian, China
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Weilin Huang
3Department of Radiology, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
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Qixuan Li
1Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
2Department of Neurosurgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, Fujian, China
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Ke Ma
4Clinical Research and Translation Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
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Shuna Huang
4Clinical Research and Translation Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
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Xinru Lin
4Clinical Research and Translation Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
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Weiheng Zhuang
1Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
2Department of Neurosurgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, Fujian, China
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Haojie Wang
1Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
2Department of Neurosurgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, Fujian, China
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Darong Chen
1Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
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Huimin Wang
1Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
2Department of Neurosurgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, Fujian, China
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Qiu He
1Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
2Department of Neurosurgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, Fujian, China
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Zhuyu Gao
1Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
2Department of Neurosurgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, Fujian, China
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Xuegang Niu
1Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
2Department of Neurosurgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, Fujian, China
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Yajun Jing
1Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
2Department of Neurosurgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, Fujian, China
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Lingjun Yan
5Fujian Provincial Institutes of Brain Disorders and Brain Sciences, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
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Bin Gao
5Fujian Provincial Institutes of Brain Disorders and Brain Sciences, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
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Dengliang Wang
1Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
2Department of Neurosurgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, Fujian, China
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Shaowei Lin
6Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian, China
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Siying Wu
6Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian, China
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Yuanxiang Lin
1Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
2Department of Neurosurgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, Fujian, China
5Fujian Provincial Institutes of Brain Disorders and Brain Sciences, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
7Fujian Provincial Clinical Research Center for Neurological Diseases, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
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Dezhi Kang
1Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
2Department of Neurosurgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, Fujian, China
4Clinical Research and Translation Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
5Fujian Provincial Institutes of Brain Disorders and Brain Sciences, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
7Fujian Provincial Clinical Research Center for Neurological Diseases, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
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Fuxin Lin
1Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
2Department of Neurosurgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, Fujian, China
4Clinical Research and Translation Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
5Fujian Provincial Institutes of Brain Disorders and Brain Sciences, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
7Fujian Provincial Clinical Research Center for Neurological Diseases, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
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Article Information

DOI 
https://doi.org/10.1136/svn-2023-003004
PubMed 
38749536

Print ISSN 
2059-8688
Online ISSN 
2059-8696
History 
  • Received November 28, 2023
  • Accepted March 2, 2024
  • Published online May 15, 2024.

Article Versions

  • You are currently viewing a Previous version of this article (May 15, 2024 - 00:20).
  • View the most recent version of this article
Copyright & Usage 
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

Author Information

  1. Chunwang Li1,2,
  2. Lingyun Zhuo1,
  3. Yaqing Kang3,
  4. Penghui Liu1,2,
  5. Weilin Huang3,
  6. Qixuan Li1,2,
  7. Ke Ma4,
  8. Shuna Huang4,
  9. Xinru Lin4,
  10. Weiheng Zhuang1,2,
  11. Haojie Wang1,2,
  12. Darong Chen1,
  13. Huimin Wang1,2,
  14. Qiu He1,2,
  15. Zhuyu Gao1,2,
  16. Xuegang Niu1,2,
  17. Yajun Jing1,2,
  18. Lingjun Yan5,
  19. Bin Gao5,
  20. Dengliang Wang1,2,
  21. Shaowei Lin6,
  22. Siying Wu6,
  23. Yuanxiang Lin1,2,5,7,
  24. Dezhi Kang1,2,4,5,7,
  25. Fuxin Lin1,2,4,5,7
  1. 1Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
  2. 2Department of Neurosurgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, Fujian, China
  3. 3Department of Radiology, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
  4. 4Clinical Research and Translation Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
  5. 5Fujian Provincial Institutes of Brain Disorders and Brain Sciences, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
  6. 6Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian, China
  7. 7Fujian Provincial Clinical Research Center for Neurological Diseases, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China
  1. Correspondence to Dr Yuanxiang Lin; lyx99070{at}126.com; Professor Dezhi Kang; kdz99988{at}vip.sina.com; Dr Fuxin Lin; lfxstudy{at}126.com
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Prevalence, genetic and clinical characteristics in first-degree relatives of patients with familial cerebral cavernous malformations in China
Chunwang Li, Lingyun Zhuo, Yaqing Kang, Penghui Liu, Weilin Huang, Qixuan Li, Ke Ma, Shuna Huang, Xinru Lin, Weiheng Zhuang, Haojie Wang, Darong Chen, Huimin Wang, Qiu He, Zhuyu Gao, Xuegang Niu, Yajun Jing, Lingjun Yan, Bin Gao, Dengliang Wang, Shaowei Lin, Siying Wu, Yuanxiang Lin, Dezhi Kang, Fuxin Lin
Stroke and Vascular Neurology May 2024, svn-2023-003004; DOI: 10.1136/svn-2023-003004

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Prevalence, genetic and clinical characteristics in first-degree relatives of patients with familial cerebral cavernous malformations in China
Chunwang Li, Lingyun Zhuo, Yaqing Kang, Penghui Liu, Weilin Huang, Qixuan Li, Ke Ma, Shuna Huang, Xinru Lin, Weiheng Zhuang, Haojie Wang, Darong Chen, Huimin Wang, Qiu He, Zhuyu Gao, Xuegang Niu, Yajun Jing, Lingjun Yan, Bin Gao, Dengliang Wang, Shaowei Lin, Siying Wu, Yuanxiang Lin, Dezhi Kang, Fuxin Lin
Stroke and Vascular Neurology May 2024, svn-2023-003004; DOI: 10.1136/svn-2023-003004
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Prevalence, genetic and clinical characteristics in first-degree relatives of patients with familial cerebral cavernous malformations in China
Chunwang Li, Lingyun Zhuo, Yaqing Kang, Penghui Liu, Weilin Huang, Qixuan Li, Ke Ma, Shuna Huang, Xinru Lin, Weiheng Zhuang, Haojie Wang, Darong Chen, Huimin Wang, Qiu He, Zhuyu Gao, Xuegang Niu, Yajun Jing, Lingjun Yan, Bin Gao, Dengliang Wang, Shaowei Lin, Siying Wu, Yuanxiang Lin, Dezhi Kang, Fuxin Lin
Stroke and Vascular Neurology May 2024, svn-2023-003004; DOI: 10.1136/svn-2023-003004
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