Open Access
Genome sequencing reveals the role of rare genomic variants in Chinese patients with symptomatic intracranial atherosclerotic disease
Mengmeng Shi, Xinyi Leng, Ying Li, Zihan Chen, Ye Cao, Tiffany Chung, Bonaventure YM Ip, Vincent HL Ip, Yannie OY Soo, Florence SY Fan, Sze Ho Ma, Karen Ma, Anne Y Y Chan, Lisa WC Au, Howan Leung, Alexander Y Lau, Vincent CT Mok, Kwong Wai Choy, Zirui Dong, Thomas W Leung
DOI: 10.1136/svn-2021-001157 Published 24 June 2022
Mengmeng Shi
1
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, China
2
Key Laboratory for Regenerative Medicine, Ministry of Education (Shenzhen Base), Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China
3
Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong, China
Xinyi Leng
4
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Ying Li
1
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, China
2
Key Laboratory for Regenerative Medicine, Ministry of Education (Shenzhen Base), Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China
3
Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong, China
Zihan Chen
1
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, China
2
Key Laboratory for Regenerative Medicine, Ministry of Education (Shenzhen Base), Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China
3
Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong, China
Ye Cao
1
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, China
5
Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong, China
Tiffany Chung
4
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Bonaventure YM Ip
4
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Vincent HL Ip
4
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Yannie OY Soo
4
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Florence SY Fan
4
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Sze Ho Ma
4
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Karen Ma
4
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Anne Y Y Chan
4
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Lisa WC Au
4
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Howan Leung
4
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Alexander Y Lau
4
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Vincent CT Mok
4
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Kwong Wai Choy
1
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, China
2
Key Laboratory for Regenerative Medicine, Ministry of Education (Shenzhen Base), Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China
3
Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong, China
6
The Chinese University of Hong Kong-Baylor College of Medicine Joint Center For Medical Genetics, The Chinese University of Hong Kong, Hong Kong, China
Zirui Dong
1
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, China
2
Key Laboratory for Regenerative Medicine, Ministry of Education (Shenzhen Base), Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China
3
Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong, China
Thomas W Leung
4
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China

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Genome sequencing reveals the role of rare genomic variants in Chinese patients with symptomatic intracranial atherosclerotic disease
Mengmeng Shi, Xinyi Leng, Ying Li, Zihan Chen, Ye Cao, Tiffany Chung, Bonaventure YM Ip, Vincent HL Ip, Yannie OY Soo, Florence SY Fan, Sze Ho Ma, Karen Ma, Anne Y Y Chan, Lisa WC Au, Howan Leung, Alexander Y Lau, Vincent CT Mok, Kwong Wai Choy, Zirui Dong, Thomas W Leung
Stroke and Vascular Neurology Jun 2022, 7 (3) 182-189; DOI: 10.1136/svn-2021-001157

Genome sequencing reveals the role of rare genomic variants in Chinese patients with symptomatic intracranial atherosclerotic disease
Mengmeng Shi, Xinyi Leng, Ying Li, Zihan Chen, Ye Cao, Tiffany Chung, Bonaventure YM Ip, Vincent HL Ip, Yannie OY Soo, Florence SY Fan, Sze Ho Ma, Karen Ma, Anne Y Y Chan, Lisa WC Au, Howan Leung, Alexander Y Lau, Vincent CT Mok, Kwong Wai Choy, Zirui Dong, Thomas W Leung
Stroke and Vascular Neurology Jun 2022, 7 (3) 182-189; DOI: 10.1136/svn-2021-001157
Genome sequencing reveals the role of rare genomic variants in Chinese patients with symptomatic intracranial atherosclerotic disease
Mengmeng Shi, Xinyi Leng, Ying Li, Zihan Chen, Ye Cao, Tiffany Chung, Bonaventure YM Ip, Vincent HL Ip, Yannie OY Soo, Florence SY Fan, Sze Ho Ma, Karen Ma, Anne Y Y Chan, Lisa WC Au, Howan Leung, Alexander Y Lau, Vincent CT Mok, Kwong Wai Choy, Zirui Dong, Thomas W Leung
Stroke and Vascular Neurology Jun 2022, 7 (3) 182-189; DOI: 10.1136/svn-2021-001157