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Genome sequencing reveals the role of rare genomic variants in Chinese patients with symptomatic intracranial atherosclerotic disease

Mengmeng Shi, Xinyi Leng, Ying Li, Zihan Chen, Ye Cao, Tiffany Chung, Bonaventure YM Ip, Vincent HL Ip, Yannie OY Soo, Florence SY Fan, Sze Ho Ma, Karen Ma, Anne Y Y Chan, Lisa WC Au, Howan Leung, Alexander Y Lau, Vincent CT Mok, Kwong Wai Choy, Zirui Dong, Thomas W Leung
DOI: 10.1136/svn-2021-001157 Published 24 June 2022
Mengmeng Shi
1 Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, China
2 Key Laboratory for Regenerative Medicine, Ministry of Education (Shenzhen Base), Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China
3 Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong, China
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Xinyi Leng
4 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
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  • ORCID record for Xinyi Leng
Ying Li
1 Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, China
2 Key Laboratory for Regenerative Medicine, Ministry of Education (Shenzhen Base), Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China
3 Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong, China
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Zihan Chen
1 Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, China
2 Key Laboratory for Regenerative Medicine, Ministry of Education (Shenzhen Base), Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China
3 Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong, China
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Ye Cao
1 Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, China
5 Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong, China
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Tiffany Chung
4 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
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Bonaventure YM Ip
4 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
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Vincent HL Ip
4 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
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Yannie OY Soo
4 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
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Florence SY Fan
4 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
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Sze Ho Ma
4 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
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Karen Ma
4 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
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Anne Y Y Chan
4 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
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Lisa WC Au
4 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
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Howan Leung
4 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
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Alexander Y Lau
4 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
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Vincent CT Mok
4 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
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Kwong Wai Choy
1 Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, China
2 Key Laboratory for Regenerative Medicine, Ministry of Education (Shenzhen Base), Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China
3 Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong, China
6 The Chinese University of Hong Kong-Baylor College of Medicine Joint Center For Medical Genetics, The Chinese University of Hong Kong, Hong Kong, China
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Zirui Dong
1 Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, China
2 Key Laboratory for Regenerative Medicine, Ministry of Education (Shenzhen Base), Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China
3 Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong, China
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Thomas W Leung
4 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
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Article Information

vol. 7 no. 3 182-189
DOI 
https://doi.org/10.1136/svn-2021-001157
PubMed 
34880113

Print ISSN 
2059-8688
Online ISSN 
2059-8696
History 
  • Received June 4, 2021
  • Accepted October 27, 2021
  • Published online June 24, 2022.

Article Versions

  • Previous version (December 8, 2021 - 07:33).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

Author Information

  1. Mengmeng Shi1,2,3,
  2. Xinyi Leng4,
  3. Ying Li1,2,3,
  4. Zihan Chen1,2,3,
  5. Ye Cao1,5,
  6. Tiffany Chung4,
  7. Bonaventure YM Ip4,
  8. Vincent HL Ip4,
  9. Yannie OY Soo4,
  10. Florence SY Fan4,
  11. Sze Ho Ma4,
  12. Karen Ma4,
  13. Anne Y Y Chan4,
  14. Lisa WC Au4,
  15. Howan Leung4,
  16. Alexander Y Lau4,
  17. Vincent CT Mok4,
  18. Kwong Wai Choy1,2,3,6,
  19. Zirui Dong1,2,3,
  20. Thomas W Leung4
  1. 1 Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, China
  2. 2 Key Laboratory for Regenerative Medicine, Ministry of Education (Shenzhen Base), Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China
  3. 3 Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong, China
  4. 4 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
  5. 5 Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong, China
  6. 6 The Chinese University of Hong Kong-Baylor College of Medicine Joint Center For Medical Genetics, The Chinese University of Hong Kong, Hong Kong, China
  1. Correspondence to Dr Zirui Dong; elvisdong{at}cuhk.edu.hk; Professor Thomas W Leung; drtleung{at}cuhk.edu.hk
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Genome sequencing reveals the role of rare genomic variants in Chinese patients with symptomatic intracranial atherosclerotic disease
Mengmeng Shi, Xinyi Leng, Ying Li, Zihan Chen, Ye Cao, Tiffany Chung, Bonaventure YM Ip, Vincent HL Ip, Yannie OY Soo, Florence SY Fan, Sze Ho Ma, Karen Ma, Anne Y Y Chan, Lisa WC Au, Howan Leung, Alexander Y Lau, Vincent CT Mok, Kwong Wai Choy, Zirui Dong, Thomas W Leung
Stroke and Vascular Neurology Jun 2022, 7 (3) 182-189; DOI: 10.1136/svn-2021-001157

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Genome sequencing reveals the role of rare genomic variants in Chinese patients with symptomatic intracranial atherosclerotic disease
Mengmeng Shi, Xinyi Leng, Ying Li, Zihan Chen, Ye Cao, Tiffany Chung, Bonaventure YM Ip, Vincent HL Ip, Yannie OY Soo, Florence SY Fan, Sze Ho Ma, Karen Ma, Anne Y Y Chan, Lisa WC Au, Howan Leung, Alexander Y Lau, Vincent CT Mok, Kwong Wai Choy, Zirui Dong, Thomas W Leung
Stroke and Vascular Neurology Jun 2022, 7 (3) 182-189; DOI: 10.1136/svn-2021-001157
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Genome sequencing reveals the role of rare genomic variants in Chinese patients with symptomatic intracranial atherosclerotic disease
Mengmeng Shi, Xinyi Leng, Ying Li, Zihan Chen, Ye Cao, Tiffany Chung, Bonaventure YM Ip, Vincent HL Ip, Yannie OY Soo, Florence SY Fan, Sze Ho Ma, Karen Ma, Anne Y Y Chan, Lisa WC Au, Howan Leung, Alexander Y Lau, Vincent CT Mok, Kwong Wai Choy, Zirui Dong, Thomas W Leung
Stroke and Vascular Neurology Jun 2022, 7 (3) 182-189; DOI: 10.1136/svn-2021-001157
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