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Exosomes-mediated delivery of miR-486-3p alleviates neuroinflammation via SIRT2-mediated inhibition of mitophagy after subarachnoid hemorrhage

Bin Sheng, Sen Gao, XiangXin Chen, Yang Liu, Niansheng Lai, Jin Dong, Jiaqing Sun, Yan Zhou, Lingyun Wu, Chun-Hua Hang, Wei Li
DOI: 10.1136/svn-2024-003509 Published 2 October 2024
Bin Sheng
1Department of Neurosurgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
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Sen Gao
1Department of Neurosurgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
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XiangXin Chen
1Department of Neurosurgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
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Yang Liu
2Department of Neurosurgery, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China
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Niansheng Lai
3Department of Neurosurgery, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, China
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Jin Dong
4Department of Outpatient, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, China
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Jiaqing Sun
5Department of Neurosurgery, Nanjing Drum Tower Hospital Clinical College of Xuzhou Medical University, Xuzhou, Jiangsu, China
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Yan Zhou
1Department of Neurosurgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
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Lingyun Wu
1Department of Neurosurgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
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Chun-Hua Hang
1Department of Neurosurgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
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Wei Li
1Department of Neurosurgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
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Article Information

DOI 
https://doi.org/10.1136/svn-2024-003509
PubMed 
39357894

Print ISSN 
2059-8688
Online ISSN 
2059-8696
History 
  • Received June 27, 2024
  • Accepted September 4, 2024
  • Published online October 2, 2024.

Copyright & Usage 
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

Author Information

  1. Bin Sheng1,
  2. Sen Gao1,
  3. XiangXin Chen1,
  4. Yang Liu2,
  5. Niansheng Lai3,
  6. Jin Dong4,
  7. Jiaqing Sun5,
  8. Yan Zhou1,
  9. Lingyun Wu1,
  10. Chun-Hua Hang1,
  11. Wei Li1
  1. 1Department of Neurosurgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
  2. 2Department of Neurosurgery, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China
  3. 3Department of Neurosurgery, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, China
  4. 4Department of Outpatient, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, China
  5. 5Department of Neurosurgery, Nanjing Drum Tower Hospital Clinical College of Xuzhou Medical University, Xuzhou, Jiangsu, China
  1. Correspondence to Dr Wei Li; wei.li{at}nju.edu.cn; Professor Chun-Hua Hang; hang_neurosurgery{at}163.com; Dr Lingyun Wu; Dr.wulingyun{at}gmail.com
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Exosomes-mediated delivery of miR-486-3p alleviates neuroinflammation via SIRT2-mediated inhibition of mitophagy after subarachnoid hemorrhage
Bin Sheng, Sen Gao, XiangXin Chen, Yang Liu, Niansheng Lai, Jin Dong, Jiaqing Sun, Yan Zhou, Lingyun Wu, Chun-Hua Hang, Wei Li
Stroke and Vascular Neurology Oct 2024, svn-2024-003509; DOI: 10.1136/svn-2024-003509

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Exosomes-mediated delivery of miR-486-3p alleviates neuroinflammation via SIRT2-mediated inhibition of mitophagy after subarachnoid hemorrhage
Bin Sheng, Sen Gao, XiangXin Chen, Yang Liu, Niansheng Lai, Jin Dong, Jiaqing Sun, Yan Zhou, Lingyun Wu, Chun-Hua Hang, Wei Li
Stroke and Vascular Neurology Oct 2024, svn-2024-003509; DOI: 10.1136/svn-2024-003509
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Exosomes-mediated delivery of miR-486-3p alleviates neuroinflammation via SIRT2-mediated inhibition of mitophagy after subarachnoid hemorrhage
Bin Sheng, Sen Gao, XiangXin Chen, Yang Liu, Niansheng Lai, Jin Dong, Jiaqing Sun, Yan Zhou, Lingyun Wu, Chun-Hua Hang, Wei Li
Stroke and Vascular Neurology Oct 2024, svn-2024-003509; DOI: 10.1136/svn-2024-003509
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