Article Figures & Data
- Table 1
Overview of the four existing approaches to define WMH change
Approach Regression Stable Progression Threshold 112 Decrease>0.25 mL Volumes from −0.25 mL up to 1 SD (of mean WMH volume change) Increase >1 SD (of mean WMH volume change) Threshold 23 Decrease>0.25 mL Volumes from −0.25 mL up to +0.25 mL Increase >0.25 mL Percentile4 Percentiles below the −10th percentile of no change Percentile of no volume change ±10 percentiles Percentiles above the +10th percentile of no change Quintile7 Data are divided in quintiles reflecting any net volume change. Quintile 1 (Q1): most volume decrease; quintile 5 (Q5): most volume increase WMH, white matter hyperintensity.
- Table 2
Participant distribution and WMH volume change (mL) after applying the four approaches to one dataset
Approach N (%) regression Regressing WMH change (mL) N (%) stable Stable WMH change (mL) N (%) progression Progressing WMH change (mL) Threshold 1 Mean volume (SD), (range) 59
(29.8)−1.36 (1.42)
(−7.98 to –0.26)110
(55.6)0.86 (0.89)
(−0.23, 2.81)29
(14.6)6.22 (3.07)
(2.88, 12.84)Threshold 2 Mean volume (SD), (range) 59
(29.8)−1.36 (1.42)
(−7.98 to –0.26)33
(16.7)−0.02 (0.14)
(−0.23, 0.22)106
(53.5)2.59 (2.82)
(0.25, 12.84)Percentile Mean volume (SD), (range) 56
(28.3)−1.42 (1.43)
(−7.98 to –0.33)42
(21.2)−0.01 (0.18)
(−0.28, 0.30)100
(50.5)2.73 (2.85)
(0.32, 12.84)Quintile Q1
(N=40)Q2
(N=40)Q3
(N=40)Q4
(N=39)Q5
(N=39)Mean (SD), (range) −1.79 (1.54)
(−7.98 to –0.68)−0.27 (0.20)
(−0.65, 0.03)0.35 (0.18)
(0.04, 0.70)1.43 (0.48)
(0.75, 2.33)5.31 (3.07)
(2.43, 12.84)Q, quintile; WMH, white matter hyperintensity.
Supplementary Materials
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