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Definitions of white matter hyperintensity change: impact on estimates of progression and regression

Angela C C Jochems, Susana Muñoz Maniega, Una Clancy, Carmen Arteaga Reyes, Daniela Jaime Garcia, Maria del C. Valdés Hernández, Francesca M Chappell, Gayle Barclay, Charlotte Jardine, Donna McIntyre, Iona Gerrish, Stewart Wiseman, Michael S Stringer, Michael J Thrippleton, Fergus Doubal, Joanna M Wardlaw
DOI: 10.1136/svn-2024-003300 Published 2 October 2024
Angela C C Jochems
1UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK
2Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK
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Susana Muñoz Maniega
2Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK
3The University of Edinburgh, Edinburgh Imaging Facility, Edinburgh, UK
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Una Clancy
1UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK
2Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK
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Carmen Arteaga Reyes
1UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK
2Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK
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Daniela Jaime Garcia
1UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK
2Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK
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Maria del C. Valdés Hernández
2Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK
3The University of Edinburgh, Edinburgh Imaging Facility, Edinburgh, UK
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Francesca M Chappell
1UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK
2Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK
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Gayle Barclay
3The University of Edinburgh, Edinburgh Imaging Facility, Edinburgh, UK
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Charlotte Jardine
3The University of Edinburgh, Edinburgh Imaging Facility, Edinburgh, UK
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Donna McIntyre
3The University of Edinburgh, Edinburgh Imaging Facility, Edinburgh, UK
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Iona Gerrish
3The University of Edinburgh, Edinburgh Imaging Facility, Edinburgh, UK
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Stewart Wiseman
2Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK
3The University of Edinburgh, Edinburgh Imaging Facility, Edinburgh, UK
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Michael S Stringer
1UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK
2Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK
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Michael J Thrippleton
2Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK
3The University of Edinburgh, Edinburgh Imaging Facility, Edinburgh, UK
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Fergus Doubal
1UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK
2Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK
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Joanna M Wardlaw
1UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK
2Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK
3The University of Edinburgh, Edinburgh Imaging Facility, Edinburgh, UK
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Article Information

DOI 
https://doi.org/10.1136/svn-2024-003300
PubMed 
39357898

Print ISSN 
2059-8688
Online ISSN 
2059-8696
History 
  • Received April 2, 2024
  • Accepted September 4, 2024
  • Published online October 2, 2024.

Copyright & Usage 
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

Author Information

  1. Angela C C Jochems1,2,
  2. Susana Muñoz Maniega2,3,
  3. Una Clancy1,2,
  4. Carmen Arteaga Reyes1,2,
  5. Daniela Jaime Garcia1,2,
  6. Maria del C. Valdés Hernández2,3,
  7. Francesca M Chappell1,2,
  8. Gayle Barclay3,
  9. Charlotte Jardine3,
  10. Donna McIntyre3,
  11. Iona Gerrish3,
  12. Stewart Wiseman2,3,
  13. Michael S Stringer1,2,
  14. Michael J Thrippleton2,3,
  15. Fergus Doubal1,2,
  16. Joanna M Wardlaw1,2,3
  1. 1UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK
  2. 2Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK
  3. 3The University of Edinburgh, Edinburgh Imaging Facility, Edinburgh, UK
  1. Correspondence to Professor Joanna M Wardlaw; joanna.wardlaw{at}ed.ac.uk
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Definitions of white matter hyperintensity change: impact on estimates of progression and regression
Angela C C Jochems, Susana Muñoz Maniega, Una Clancy, Carmen Arteaga Reyes, Daniela Jaime Garcia, Maria del C. Valdés Hernández, Francesca M Chappell, Gayle Barclay, Charlotte Jardine, Donna McIntyre, Iona Gerrish, Stewart Wiseman, Michael S Stringer, Michael J Thrippleton, Fergus Doubal, Joanna M Wardlaw
Stroke and Vascular Neurology Oct 2024, svn-2024-003300; DOI: 10.1136/svn-2024-003300

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Definitions of white matter hyperintensity change: impact on estimates of progression and regression
Angela C C Jochems, Susana Muñoz Maniega, Una Clancy, Carmen Arteaga Reyes, Daniela Jaime Garcia, Maria del C. Valdés Hernández, Francesca M Chappell, Gayle Barclay, Charlotte Jardine, Donna McIntyre, Iona Gerrish, Stewart Wiseman, Michael S Stringer, Michael J Thrippleton, Fergus Doubal, Joanna M Wardlaw
Stroke and Vascular Neurology Oct 2024, svn-2024-003300; DOI: 10.1136/svn-2024-003300
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Definitions of white matter hyperintensity change: impact on estimates of progression and regression
Angela C C Jochems, Susana Muñoz Maniega, Una Clancy, Carmen Arteaga Reyes, Daniela Jaime Garcia, Maria del C. Valdés Hernández, Francesca M Chappell, Gayle Barclay, Charlotte Jardine, Donna McIntyre, Iona Gerrish, Stewart Wiseman, Michael S Stringer, Michael J Thrippleton, Fergus Doubal, Joanna M Wardlaw
Stroke and Vascular Neurology Oct 2024, svn-2024-003300; DOI: 10.1136/svn-2024-003300
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