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Trendelenburg position for acute anterior circulation ischaemic stroke with large artery atherosclerosis aetiology (HOPES 3): rationale and design

Xiaoqiu Li, Zhenni Guo, Lu Wang, Yue Wang, Thanh Nguyen, Yi Yang, Hui-Sheng Chen
DOI: 10.1136/svn-2023-002868 Published 31 January 2024
Xiaoqiu Li
1Department of Neurology, General Hospital of Northern Theater Command, Shenyang, Liaoning Province, China
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Zhenni Guo
2The First Hospital of Jilin University, Changchun, Jilin, China
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Lu Wang
1Department of Neurology, General Hospital of Northern Theater Command, Shenyang, Liaoning Province, China
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Yue Wang
1Department of Neurology, General Hospital of Northern Theater Command, Shenyang, Liaoning Province, China
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Thanh Nguyen
3Neurology, Radiology, Boston Medical Center, Boston, Massachusetts, USA
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Yi Yang
2The First Hospital of Jilin University, Changchun, Jilin, China
4Stroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin, China
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Hui-Sheng Chen
1Department of Neurology, General Hospital of Northern Theater Command, Shenyang, Liaoning Province, China
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    Figure 1

    Study flowchart. HDP, head-down position; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale.

Tables

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  • Table 1

    Timing of all procedures in Head dOwn-Position for acutE moderate ischaemic Stroke with large artery atherosclerosis(HOPES 3)

    TimepointScreening048±12 hours10±2 days90±7 days
    Eligibility screenx
    Informed consentx
    Randomisationx
    Head CT/MRIx*x
    NIHSS assessmentxxx
    Prestroke mRS assessmentxx
    Medical historyx
    Population characteristicsx
    Vital signsxxxx
    TOAST classificationx
    Blood routinex
    Coagulationx
    Serum biochemistryx
    ECGx
    24-hour ECG monitorx†
    Concomitant medicationxxx
    Adverse eventsxxx
    Recurrent stroke and other vascular eventsxxx
    • *MRI including diffusion-weighted imaging is required either at baseline or at 48 hours.

    • †Performed within 10 days after admission.

    • mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; TOAST, Trial of Org 10 172 in Acute Stroke Treatment.

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Stroke and Vascular Neurology: 10 (1)
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Trendelenburg position for acute anterior circulation ischaemic stroke with large artery atherosclerosis aetiology (HOPES 3): rationale and design
Xiaoqiu Li, Zhenni Guo, Lu Wang, Yue Wang, Thanh Nguyen, Yi Yang, Hui-Sheng Chen
Stroke and Vascular Neurology Jan 2024, svn-2023-002868; DOI: 10.1136/svn-2023-002868

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Trendelenburg position for acute anterior circulation ischaemic stroke with large artery atherosclerosis aetiology (HOPES 3): rationale and design
Xiaoqiu Li, Zhenni Guo, Lu Wang, Yue Wang, Thanh Nguyen, Yi Yang, Hui-Sheng Chen
Stroke and Vascular Neurology Jan 2024, svn-2023-002868; DOI: 10.1136/svn-2023-002868
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Trendelenburg position for acute anterior circulation ischaemic stroke with large artery atherosclerosis aetiology (HOPES 3): rationale and design
Xiaoqiu Li, Zhenni Guo, Lu Wang, Yue Wang, Thanh Nguyen, Yi Yang, Hui-Sheng Chen
Stroke and Vascular Neurology Jan 2024, svn-2023-002868; DOI: 10.1136/svn-2023-002868
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