Tenecteplase thrombolysis for stroke up to 24 hours after onset with perfusion imaging selection: the umbrella phase IIa CHABLIS-T randomised clinical trial

Xin Cheng; Lan Hong; Leonid Churilov; Longting Lin; Yifeng Ling; Jin Zhang; Jianhong Yang; Yu Geng; Danhong Wu; Xueyuan Liu; Xiaoyu Zhou; Yuwu Zhao; Qijin Zhai; Liandong Zhao; Yangmei Chen; Ying Guo; Xiaofei Yu; Fan Gong; Yi Sui; Gang Li; Lumeng Yang; Hong-Qiu Gu; Yilong Wang; Mark Parsons; Qiang Dong

doi:10.1136/svn-2023-002820

Open Access

Tenecteplase thrombolysis for stroke up to 24 hours after onset with perfusion imaging selection: the umbrella phase IIa CHABLIS-T randomised clinical trial

Xin Cheng, Lan Hong, Leonid Churilov, Longting Lin, Yifeng Ling, Jin Zhang, Jianhong Yang, Yu Geng, Danhong Wu, Xueyuan Liu, Xiaoyu Zhou, Yuwu Zhao, Qijin Zhai, Liandong Zhao, Yangmei Chen, Ying Guo, Xiaofei Yu, Fan Gong, Yi Sui, Gang Li, Lumeng Yang, Hong-Qiu Gu, Yilong Wang, Mark Parsons, Qiang Dong

DOI: 10.1136/svn-2023-002820 Published 29 January 2024

Xin Cheng

1Department of Neurology, National Center for Neurological Disorders, National Clinical Research Centre for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China

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Lan Hong

1Department of Neurology, National Center for Neurological Disorders, National Clinical Research Centre for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China

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Leonid Churilov

2Melbourne Medical School, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia

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Longting Lin

3University of New South Wales South Western Sydney Clinical School, Ingham Institute for Applied Medical Research, Department of Neurology, Liverpool Hospital, Sydney, New South Wales, Australia

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Yifeng Ling

1Department of Neurology, National Center for Neurological Disorders, National Clinical Research Centre for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China

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Jin Zhang

4Department of Neurology, the First Hospital of Shanxi Medical University, Taiyuan, China

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Jianhong Yang

5Department of Neurology, Ningbo First Hospital, Ningbo, China

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Yu Geng

6Center for Rehabilitation Medicine, Department of Neurology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, China

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Danhong Wu

7Department of Neurology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China

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Xueyuan Liu

8Department of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China

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Xiaoyu Zhou

8Department of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China

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Yuwu Zhao

9Department of Neurology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Qijin Zhai

10Department of Neurology, Xuzhou Medical University Affiliated Hospital of Huaian, Huaian, China

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Liandong Zhao

10Department of Neurology, Xuzhou Medical University Affiliated Hospital of Huaian, Huaian, China

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Yangmei Chen

11Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Ying Guo

12Department of Neurology, Pu'er People's Hospital, Pu'er, China

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Xiaofei Yu

13Department of Neurology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China

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Fan Gong

13Department of Neurology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China

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Yi Sui

14Department of Neurology, Shenyang First People's Hospital, Shenyang Medical College Affiliated Brain Hospital, Shenyang, China

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Gang Li

15Department of Neurology, Shanghai East Hospital, Tongji University, Shanghai, China

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Lumeng Yang

1Department of Neurology, National Center for Neurological Disorders, National Clinical Research Centre for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China

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Hong-Qiu Gu

16China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China

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Yilong Wang

16China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China

17Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Mark Parsons

3University of New South Wales South Western Sydney Clinical School, Ingham Institute for Applied Medical Research, Department of Neurology, Liverpool Hospital, Sydney, New South Wales, Australia

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Qiang Dong

1Department of Neurology, National Center for Neurological Disorders, National Clinical Research Centre for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China

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Tenecteplase thrombolysis for stroke up to 24 hours after onset with perfusion imaging selection: the umbrella phase IIa CHABLIS-T randomised clinical trial

Stroke and Vascular Neurology Jan 2024, svn-2023-002820; DOI: 10.1136/svn-2023-002820

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Tenecteplase thrombolysis for stroke up to 24 hours after onset with perfusion imaging selection: the umbrella phase IIa CHABLIS-T randomised clinical trial

Stroke and Vascular Neurology Jan 2024, svn-2023-002820; DOI: 10.1136/svn-2023-002820

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Tenecteplase thrombolysis for stroke up to 24 hours after onset with perfusion imaging selection: the umbrella phase IIa CHABLIS-T randomised clinical trial

Stroke and Vascular Neurology Jan 2024, svn-2023-002820; DOI: 10.1136/svn-2023-002820

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