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Comparison of carotid endarterectomy and repeated carotid angioplasty and stenting for in-stent restenosis (CERCAS trial): a randomised study

Tomáš Hrbáč, Jiří Fiedler, Václav Procházka, Tomáš Jonszta, Martin Roubec, David Pakizer, Daniel Václavík, David Netuka, Tomáš Heryán, David Školoudík
DOI: 10.1136/svn-2022-002075 Published 27 March 2023
Tomáš Hrbáč
1Department of Neuroscience, Faculty of Medicine, Univerzity of Ostrava, Ostrava, Czech Republic
2Department of Neurosurgery, University Hospital Ostrava, Ostrava, Czech Republic
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Jiří Fiedler
3Department of Neurosurgery, České Budějovice Hospital, České Budějovice, Czech Republic
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Václav Procházka
4Department of Radiology, University Hospital Ostrava, Ostrava, Czech Republic
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Tomáš Jonszta
4Department of Radiology, University Hospital Ostrava, Ostrava, Czech Republic
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Martin Roubec
5Department of Neurology, University Hospital Ostrava, Ostrava, Czech Republic
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David Pakizer
6Center for Health Research, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic
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Daniel Václavík
7Department of Neurology, Vítkovice Hospital, Ostrava, Czech Republic
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David Netuka
8Department of Neurosurgery, Military University Hospital Prague, Praha, Czech Republic
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Tomáš Heryán
6Center for Health Research, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic
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David Školoudík
5Department of Neurology, University Hospital Ostrava, Ostrava, Czech Republic
6Center for Health Research, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic
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    Figure 1

    Carotid endarterectomy with stent removal in patients with carotid in-stent restenosis. Carotid in-stent restenosis on digital subtraction angiography before surgery (A), stent removal during carotid endarterectomy (B), removed stent with atherosclerotic plaque after carotid endarterectomy (B) and histology of atherosclerotic plaque with a stent (B).

  • Figure 2
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    Figure 2

    Repeat percutaneous transluminal angioplasty in patient with carotid in-stent restenosis. Carotid in-stent restenosis on digital subtraction angiography before angioplasty (A) and residual in-stent stenosis after angioplasty (B).

Tables

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  • Table 1

    Demographic data

    CEASR groupRePTA/S GroupP value
    No of patients; n1417NA
    Male gender; n (%)9 (64.3)10 (58.8)0.756
    Age at time of randomisation; mean±SD (years)66.3±6.668.8±5.60.295
    Age at first CAS; mean±SD (years)62.7±7.265.5±5.60.250
    Severity of carotid in-stent restenosis; mean±SD (%)86.1±6.082.6±5.70.131
    Severity of carotid stenosis prior to first CAS; mean±SD (%)84.3±4.981.2±7.40.187
    Right side of in-stent restenosis; n (%)8 (57.1)11 (64.7)0.667
    Stroke/TIA/amaurosis fugax/retinal infarction medical history; n (%)8 (57.1)13 (76.5)0.224
    Symptoms (stroke/TIA/amaurosis fugax/retinal infarction) in the territory of the intervened carotid artery in medical history; n (%)5 (35.7)4 (23.5)0.363
    Arterial hypertension; n (%)12 (85.7)15 (88.2)0.622
    Diabetes mellitus; n (%)10 (71.4)8 (47.1)0.171
    Hyperlipidaemia; n (%)12 (85.7)14 (82.4)0.597
    Atrial fibrillation; n (%)2 (14.3)2 (11.8)0.622
    Coronary heart disease; n (%)9 (64.3)11 (64.7)0.981
    Myocardial infarction in medical history; n (%)3 (21.4)5 (29.4)0.466
    Other vascular intervention; n (%)8 (57.1)9 (52.9)0.815
    Smoking; n (%)10 (71.4)8 (47.1)0.171
    Alcohol use; n (%)9 (64.3)10 (58.8)0.756
    Statin use; n (%)12 (85.7)15 (88.2)0.622
    Antiplatelet treatment; n (%)13 (92.9)16 (94.1)0.708
     Acetysalicylic acid (100 mg); (%)4 (28.6)16 (94.1)
     Clopidogrel (75 mg); n (%)9 (64.3)16 (94.1)
    Anticoagulation; n (%)1 (7.1)1 (5.9)0.968
    • CAS, carotid artery stenting; CEASR, carotid endarterectomy with stent retrieval; n, number; NA, not available; rePTA/S, repeated percutaneous transluminal angioplasty with or without stenting; TIA, transient ischaemic attack.

  • Table 2

    Study results

    CEASR groupRePTA/S groupP value
    No of patients; n1417NA
    Symptomatic in-stent restenosis; n (%)0 (0)0 (0)1.000
    Duration of procedure; mean±SD (min)86.9±23.433.5±13.4<0.001
    Residual stenosis after intervention; mean±SD (%)0±020.9±6.7<0.001
    Residual stenosis (≥30%) after intervention; n (%)0 (0)4 (23.5)0.040
    Stroke/retinal infarction within 30 days after intervention; n (%)0 (0)0 (0)1.000
    TIA/amaurosis fugax within 30 days after intervention; n (%)0 (0)0 (0)1.000
    Myocardial infarction within 30 days after intervention; n (%)0 (0)0 (0)1.000
    Death within 30 days after intervention; n (%)0 (0)0 (0)1.000
    Stroke/retinal infarction within 1 year after intervention; n (%)0 (0)0 (0)1.000
    TIA/amaurosis fugax within 1 year after intervention; n (%)0 (0)0 (0)1.000
    Myocardial infarction within 1 year after intervention; n (%)0 (0)0 (0)1.000
    Death within 1 year after intervention; n (%)0 (0)1 (5.9)0.548
    Restenosis (≥70%) 1 year after intervention; n (%)1 (7.1)4 (23.5)0.233
    Local complications associated with CEASR or rePTA/S within 30 days; n (%)2 (14.3)1 (5.9)0.704
    Combined end-point; n (%)3 (21.4)5 (29.4)0.719
    • CAS, carotid artery stenting; CEASR, carotid endarterectomy with stent retrieval; n, number; NA, not available; rePTA/S, repeated percutaneous transluminal angioplasty with or without stenting; TIA, transient ischaemic attack.

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Comparison of carotid endarterectomy and repeated carotid angioplasty and stenting for in-stent restenosis (CERCAS trial): a randomised study
Tomáš Hrbáč, Jiří Fiedler, Václav Procházka, Tomáš Jonszta, Martin Roubec, David Pakizer, Daniel Václavík, David Netuka, Tomáš Heryán, David Školoudík
Stroke and Vascular Neurology Mar 2023, svn-2022-002075; DOI: 10.1136/svn-2022-002075

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Comparison of carotid endarterectomy and repeated carotid angioplasty and stenting for in-stent restenosis (CERCAS trial): a randomised study
Tomáš Hrbáč, Jiří Fiedler, Václav Procházka, Tomáš Jonszta, Martin Roubec, David Pakizer, Daniel Václavík, David Netuka, Tomáš Heryán, David Školoudík
Stroke and Vascular Neurology Mar 2023, svn-2022-002075; DOI: 10.1136/svn-2022-002075
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Comparison of carotid endarterectomy and repeated carotid angioplasty and stenting for in-stent restenosis (CERCAS trial): a randomised study
Tomáš Hrbáč, Jiří Fiedler, Václav Procházka, Tomáš Jonszta, Martin Roubec, David Pakizer, Daniel Václavík, David Netuka, Tomáš Heryán, David Školoudík
Stroke and Vascular Neurology Mar 2023, svn-2022-002075; DOI: 10.1136/svn-2022-002075
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