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Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase II randomised placebo-controlled double-blind multicentre trial

Nawaf Yassi, Henry Zhao, Leonid Churilov, Bruce C V Campbell, Teddy Wu, Henry Ma, Andrew Cheung, Timothy Kleinig, Helen Brown, Philip Choi, Jiann-Shing Jeng, Annemarei Ranta, Hao-Kuang Wang, Geoffrey C Cloud, Rohan Grimley, Darshan Shah, Neil Spratt, Der-Yang Cho, Karim Mahawish, Lauren Sanders, John Worthington, Ben Clissold, Atte Meretoja, Vignan Yogendrakumar, Mai Duy Ton, Duc Phuc Dang, Nguyen Thai My Phuong, Huy-Thang Nguyen, Chung Y Hsu, Gagan Sharma, Peter J Mitchell, Bernard Yan, Mark W Parsons, Christopher Levi, Geoffrey A Donnan, Stephen M Davis
DOI: 10.1136/svn-2021-001070 Published 30 November 2021

Article Figures & Data

Figures

  • Figure 1
    Figure 1

    Haematoma growth occurring between baseline (A, C) CT and follow-up CT (B, D) in a patient with a right basal ganglia haemorrhage. Panel C and D reflect the region of interest planimetric analysis used to measure haematoma volume (intraventricular segment measured separately).

  • Figure 2
    Figure 2

    Key trial timepoints and activities. ICH, intracerebral haemorrhage; mRS, Modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; TXA, tranexamic acid.

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Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase II randomised placebo-controlled double-blind multicentre trial
Nawaf Yassi, Henry Zhao, Leonid Churilov, Bruce C V Campbell, Teddy Wu, Henry Ma, Andrew Cheung, Timothy Kleinig, Helen Brown, Philip Choi, Jiann-Shing Jeng, Annemarei Ranta, Hao-Kuang Wang, Geoffrey C Cloud, Rohan Grimley, Darshan Shah, Neil Spratt, Der-Yang Cho, Karim Mahawish, Lauren Sanders, John Worthington, Ben Clissold, Atte Meretoja, Vignan Yogendrakumar, Mai Duy Ton, Duc Phuc Dang, Nguyen Thai My Phuong, Huy-Thang Nguyen, Chung Y Hsu, Gagan Sharma, Peter J Mitchell, Bernard Yan, Mark W Parsons, Christopher Levi, Geoffrey A Donnan, Stephen M Davis
Stroke and Vascular Neurology Nov 2021, svn-2021-001070; DOI: 10.1136/svn-2021-001070
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