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Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase II randomised placebo-controlled double-blind multicentre trial

Nawaf Yassi, Henry Zhao, Leonid Churilov, Bruce C V Campbell, Teddy Wu, Henry Ma, Andrew Cheung, Timothy Kleinig, Helen Brown, Philip Choi, Jiann-Shing Jeng, Annemarei Ranta, Hao-Kuang Wang, Geoffrey C Cloud, Rohan Grimley, Darshan Shah, Neil Spratt, Der-Yang Cho, Karim Mahawish, Lauren Sanders, John Worthington, Ben Clissold, Atte Meretoja, Vignan Yogendrakumar, Mai Duy Ton, Duc Phuc Dang, Nguyen Thai My Phuong, Huy-Thang Nguyen, Chung Y Hsu, Gagan Sharma, Peter J Mitchell, Bernard Yan, Mark W Parsons, Christopher Levi, Geoffrey A Donnan, Stephen M Davis
DOI: 10.1136/svn-2021-001070 Published 30 November 2021
Nawaf Yassi
1Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
2Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
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Henry Zhao
1Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
3Ambulance Victoria, Melbourne, Victoria, Australia
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Leonid Churilov
1Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
4Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia
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Bruce C V Campbell
1Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
5Stroke Division, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia
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Teddy Wu
6Department of Neurology, Christchurch Hospital, Christchurch, New Zealand
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Henry Ma
7Department of Neurology, Monash Medical Centre, Monash University, Clayton, Victoria, Australia
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Andrew Cheung
8Department of Interventional Neuroradiology, Liverpool Hospital, Liverpool, New South Wales, Australia
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  • ORCID record for Andrew Cheung
Timothy Kleinig
9Department of Neurology, Royal Adelaide Hospital, Adelaide, South Australia, Australia
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Helen Brown
10Department of Neurology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
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Philip Choi
11Department of Neurology, Box Hill Hospital, Eastern Health, Box Hill, Victoria, Australia
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Jiann-Shing Jeng
12Stroke Centre and Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan
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Annemarei Ranta
13Department of Medicine, Dunedin School of Medicine, University of Otago, Wellington, New Zealand
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Hao-Kuang Wang
14Department of Neurosurgery, E-Da Hospital, Yanchao, Kaohsiung, Taiwan
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Geoffrey C Cloud
15Department of Neurology, Alfred Hospital, Melbourne, Victoria, Australia
16Department of Clinical Neuroscience, Monash University Central Clinical School, Melbourne, Victoria, Australia
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Rohan Grimley
17Department of Medicine, Sunshine Coast University Hospital, Nambour, Queensland, Australia
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Darshan Shah
18Department of Neurology, Gold Coast University Hospital, Southport, Queensland, Australia
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Neil Spratt
19Department of Neurology, John Hunter Hospital, The University of Newcastle, Newcastle, New South Wales, Australia
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Der-Yang Cho
20Department of Neurosurgery, China Medical University Hospital, Taichung, Taiwan
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Karim Mahawish
21Department of Internal Medicine, Palmerston North Hospital, Palmerston North, New Zealand
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Lauren Sanders
22Department of Neurology, St Vincent's Hospital, Fitzroy, Victoria, Australia
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John Worthington
23Department of Neurology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
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Ben Clissold
24Department of Neurology, Geelong Hospital, Geelong, Victoria, Australia
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Atte Meretoja
25Department of Neurology, Helsinki University Hospital, Helsinki, Finland
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Vignan Yogendrakumar
1Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
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Mai Duy Ton
26Stroke Center, Bach Mai Hospital, Hanoi, Viet Nam
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Duc Phuc Dang
27Stroke Department, 103 Military Hospital, Hanoi, Hanoi, Viet Nam
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Nguyen Thai My Phuong
28Department of Neurology, Nguyen Tri Phuong Hospital, Ho Chi Minh City, Viet Nam
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Huy-Thang Nguyen
29Department of Cerebrovascular Disease, 115 Hospital, Ho Chi Minh City, Viet Nam
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Chung Y Hsu
30Department of Neurology, China Medical University, Taichung, Taiwan
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Gagan Sharma
1Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
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Peter J Mitchell
31Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia
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Bernard Yan
1Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
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Mark W Parsons
1Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
32Department of Neurology, Liverpool Hospital, Ingham Institute for Applied Medical Research, University of New South Wales South Western Sydney Clinical School, Sydney, New South Wales, Australia
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Christopher Levi
19Department of Neurology, John Hunter Hospital, The University of Newcastle, Newcastle, New South Wales, Australia
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Geoffrey A Donnan
1Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
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Stephen M Davis
1Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
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Article Information

DOI 
https://doi.org/10.1136/svn-2021-001070
PubMed 
34848566

Print ISSN 
2059-8688
Online ISSN 
2059-8696
History 
  • Received April 21, 2021
  • Accepted October 12, 2021
  • Published online November 30, 2021.

Article Versions

  • You are currently viewing a Previous version of this article (November 30, 2021 - 05:02).
  • View the most recent version of this article
Copyright & Usage 
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

Author Information

  1. Nawaf Yassi1,2,
  2. Henry Zhao1,3,
  3. Leonid Churilov1,4,
  4. Bruce C V Campbell1,5,
  5. Teddy Wu6,
  6. Henry Ma7,
  7. Andrew Cheung8,
  8. Timothy Kleinig9,
  9. Helen Brown10,
  10. Philip Choi11,
  11. Jiann-Shing Jeng12,
  12. Annemarei Ranta13,
  13. Hao-Kuang Wang14,
  14. Geoffrey C Cloud15,16,
  15. Rohan Grimley17,
  16. Darshan Shah18,
  17. Neil Spratt19,
  18. Der-Yang Cho20,
  19. Karim Mahawish21,
  20. Lauren Sanders22,
  21. John Worthington23,
  22. Ben Clissold24,
  23. Atte Meretoja25,
  24. Vignan Yogendrakumar1,
  25. Mai Duy Ton26,
  26. Duc Phuc Dang27,
  27. Nguyen Thai My Phuong28,
  28. Huy-Thang Nguyen29,
  29. Chung Y Hsu30,
  30. Gagan Sharma1,
  31. Peter J Mitchell31,
  32. Bernard Yan1,
  33. Mark W Parsons1,32,
  34. Christopher Levi19,
  35. Geoffrey A Donnan1,
  36. Stephen M Davis1
  1. 1Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
  2. 2Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
  3. 3Ambulance Victoria, Melbourne, Victoria, Australia
  4. 4Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia
  5. 5Stroke Division, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia
  6. 6Department of Neurology, Christchurch Hospital, Christchurch, New Zealand
  7. 7Department of Neurology, Monash Medical Centre, Monash University, Clayton, Victoria, Australia
  8. 8Department of Interventional Neuroradiology, Liverpool Hospital, Liverpool, New South Wales, Australia
  9. 9Department of Neurology, Royal Adelaide Hospital, Adelaide, South Australia, Australia
  10. 10Department of Neurology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
  11. 11Department of Neurology, Box Hill Hospital, Eastern Health, Box Hill, Victoria, Australia
  12. 12Stroke Centre and Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan
  13. 13Department of Medicine, Dunedin School of Medicine, University of Otago, Wellington, New Zealand
  14. 14Department of Neurosurgery, E-Da Hospital, Yanchao, Kaohsiung, Taiwan
  15. 15Department of Neurology, Alfred Hospital, Melbourne, Victoria, Australia
  16. 16Department of Clinical Neuroscience, Monash University Central Clinical School, Melbourne, Victoria, Australia
  17. 17Department of Medicine, Sunshine Coast University Hospital, Nambour, Queensland, Australia
  18. 18Department of Neurology, Gold Coast University Hospital, Southport, Queensland, Australia
  19. 19Department of Neurology, John Hunter Hospital, The University of Newcastle, Newcastle, New South Wales, Australia
  20. 20Department of Neurosurgery, China Medical University Hospital, Taichung, Taiwan
  21. 21Department of Internal Medicine, Palmerston North Hospital, Palmerston North, New Zealand
  22. 22Department of Neurology, St Vincent's Hospital, Fitzroy, Victoria, Australia
  23. 23Department of Neurology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
  24. 24Department of Neurology, Geelong Hospital, Geelong, Victoria, Australia
  25. 25Department of Neurology, Helsinki University Hospital, Helsinki, Finland
  26. 26Stroke Center, Bach Mai Hospital, Hanoi, Viet Nam
  27. 27Stroke Department, 103 Military Hospital, Hanoi, Hanoi, Viet Nam
  28. 28Department of Neurology, Nguyen Tri Phuong Hospital, Ho Chi Minh City, Viet Nam
  29. 29Department of Cerebrovascular Disease, 115 Hospital, Ho Chi Minh City, Viet Nam
  30. 30Department of Neurology, China Medical University, Taichung, Taiwan
  31. 31Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia
  32. 32Department of Neurology, Liverpool Hospital, Ingham Institute for Applied Medical Research, University of New South Wales South Western Sydney Clinical School, Sydney, New South Wales, Australia
  1. Correspondence to Dr Nawaf Yassi; nawaf.yassi{at}unimelb.edu.au
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Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase II randomised placebo-controlled double-blind multicentre trial
Nawaf Yassi, Henry Zhao, Leonid Churilov, Bruce C V Campbell, Teddy Wu, Henry Ma, Andrew Cheung, Timothy Kleinig, Helen Brown, Philip Choi, Jiann-Shing Jeng, Annemarei Ranta, Hao-Kuang Wang, Geoffrey C Cloud, Rohan Grimley, Darshan Shah, Neil Spratt, Der-Yang Cho, Karim Mahawish, Lauren Sanders, John Worthington, Ben Clissold, Atte Meretoja, Vignan Yogendrakumar, Mai Duy Ton, Duc Phuc Dang, Nguyen Thai My Phuong, Huy-Thang Nguyen, Chung Y Hsu, Gagan Sharma, Peter J Mitchell, Bernard Yan, Mark W Parsons, Christopher Levi, Geoffrey A Donnan, Stephen M Davis
Stroke and Vascular Neurology Nov 2021, svn-2021-001070; DOI: 10.1136/svn-2021-001070

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Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase II randomised placebo-controlled double-blind multicentre trial
Nawaf Yassi, Henry Zhao, Leonid Churilov, Bruce C V Campbell, Teddy Wu, Henry Ma, Andrew Cheung, Timothy Kleinig, Helen Brown, Philip Choi, Jiann-Shing Jeng, Annemarei Ranta, Hao-Kuang Wang, Geoffrey C Cloud, Rohan Grimley, Darshan Shah, Neil Spratt, Der-Yang Cho, Karim Mahawish, Lauren Sanders, John Worthington, Ben Clissold, Atte Meretoja, Vignan Yogendrakumar, Mai Duy Ton, Duc Phuc Dang, Nguyen Thai My Phuong, Huy-Thang Nguyen, Chung Y Hsu, Gagan Sharma, Peter J Mitchell, Bernard Yan, Mark W Parsons, Christopher Levi, Geoffrey A Donnan, Stephen M Davis
Stroke and Vascular Neurology Nov 2021, svn-2021-001070; DOI: 10.1136/svn-2021-001070
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Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase II randomised placebo-controlled double-blind multicentre trial
Nawaf Yassi, Henry Zhao, Leonid Churilov, Bruce C V Campbell, Teddy Wu, Henry Ma, Andrew Cheung, Timothy Kleinig, Helen Brown, Philip Choi, Jiann-Shing Jeng, Annemarei Ranta, Hao-Kuang Wang, Geoffrey C Cloud, Rohan Grimley, Darshan Shah, Neil Spratt, Der-Yang Cho, Karim Mahawish, Lauren Sanders, John Worthington, Ben Clissold, Atte Meretoja, Vignan Yogendrakumar, Mai Duy Ton, Duc Phuc Dang, Nguyen Thai My Phuong, Huy-Thang Nguyen, Chung Y Hsu, Gagan Sharma, Peter J Mitchell, Bernard Yan, Mark W Parsons, Christopher Levi, Geoffrey A Donnan, Stephen M Davis
Stroke and Vascular Neurology Nov 2021, svn-2021-001070; DOI: 10.1136/svn-2021-001070
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