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Intracerebral haemorrhage in patients taking different types of oral anticoagulants: a pooled individual patient data analysis from two national stroke registries

Bernhard M Siepen, Elisabeth Forfang, Mattia Branca, Boudewijn Drop, Madlaine Mueller, Martina B Goeldlin, Mira Katan, Patrik Michel, Carlo Cereda, Friedrich Medlin, Nils Peters, Susanne Renaud, Julien Niederhauser, Emmanuel Carrera, Timo Kahles, Georg Kägi, Manuel Bolognese, Stephan Salmen, Marie-Luise Mono, Alexandros A Polymeris, Susanne Wegener, Werner Z'Graggen, Johannes Kaesmacher, Michael Schaerer, Biljana Rodic, Espen Saxhaug Kristoffersen, Kristin T Larsen, Torgeir Bruun Wyller, Bastian Volbers, Thomas R Meinel, Marcel Arnold, Stefan T Engelter, Leo H Bonati, Urs Fischer, Ole Morten Rønning, David J Seiffge
DOI: 10.1136/svn-2023-002813 Published 30 December 2024
Bernhard M Siepen
1 Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
2 Graduate School for Health Sciences, University of Bern, Bern, Switzerland
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Elisabeth Forfang
3 Institute of Clinical Medicine, University of Oslo, Oslo, Norway
4 Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway
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Mattia Branca
5 CTU Bern, Department of Clinical Research, University of Bern, Bern, Switzerland
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Boudewijn Drop
1 Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
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Madlaine Mueller
1 Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
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Martina B Goeldlin
1 Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
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Mira Katan
6 Department of Neurology, University Hospital Basel, University of Basel, Basel, Switzerland
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Patrik Michel
7 Service of Neurology, Department of Clinical Neurosciences, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland
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Carlo Cereda
8 Stroke Center EOC, Neurocenter of Southern Switzerland, Lugano, Switzerland
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Friedrich Medlin
9 Stroke Unit and Division of Neurology, HFR Fribourg–Cantonal Hospital, Fribourg, Switzerland
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Nils Peters
10 Stroke Center Hirslanden, Klinik Hirslanden Zurich, Zurich, Switzerland
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Susanne Renaud
11 Division of Neurology, Pourtalès Hospital, Neuchatel, Switzerland
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Julien Niederhauser
12 Stroke Unit, GHOL, Hospital Nyon, Nyon, Switzerland
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Emmanuel Carrera
13 Stroke Research Group, Department of Clinical Neurosciences, Geneva University Hospital, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Timo Kahles
14 Department of Neurology, Cantonal Hospital Aarau, Aarau, Switzerland
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Georg Kägi
1 Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
15 Department of Neurology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland
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Manuel Bolognese
16 Neurology Department, Lucerne Cantonal Hospital (LUKS), Luzern, Switzerland
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Stephan Salmen
17 Stroke Unit, Department of Neurology, Hospital Biel, Biel, Switzerland
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Marie-Luise Mono
18 Department of Neurology, Stadtspitäler Triemli und Waid, Zurich, Switzerland
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Alexandros A Polymeris
6 Department of Neurology, University Hospital Basel, University of Basel, Basel, Switzerland
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Susanne Wegener
19 Department of Neurology and Stroke Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland
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Werner Z'Graggen
1 Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
20 Department of Neurosurgery, Inselspital, Bern University Hospital, Bern, Switzerland
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Johannes Kaesmacher
21 University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
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Michael Schaerer
22 Department of Neurology, Bürgerspital Solothurn, Solothurn, Switzerland
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Biljana Rodic
23 Stroke Unit, Department of Neurology, Cantonal Hospital Winterthur, Winterthur, Switzerland
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Espen Saxhaug Kristoffersen
24 Department of Neurology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway
25 Department of General Practice, University of Oslo, Oslo, Norway
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Kristin T Larsen
3 Institute of Clinical Medicine, University of Oslo, Oslo, Norway
4 Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway
24 Department of Neurology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway
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Torgeir Bruun Wyller
3 Institute of Clinical Medicine, University of Oslo, Oslo, Norway
4 Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway
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Bastian Volbers
1 Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
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Thomas R Meinel
1 Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
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Marcel Arnold
1 Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
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Stefan T Engelter
6 Department of Neurology, University Hospital Basel, University of Basel, Basel, Switzerland
26 Department of Neurology and Neurorehabilitation, University of Basel; University Department of Geriatric Medicine Felix Platter, University of Basel, Basel, Switzerland
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Leo H Bonati
6 Department of Neurology, University Hospital Basel, University of Basel, Basel, Switzerland
27 Rehabilitation Clinic Rheinfelden, Rheinfelden, Switzerland
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Urs Fischer
1 Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
6 Department of Neurology, University Hospital Basel, University of Basel, Basel, Switzerland
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Ole Morten Rønning
3 Institute of Clinical Medicine, University of Oslo, Oslo, Norway
24 Department of Neurology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway
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David J Seiffge
1 Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
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Article Information

vol. 9 no. 6 640-651
DOI 
https://doi.org/10.1136/svn-2023-002813
PubMed 
38336370

Print ISSN 
2059-8688
Online ISSN 
2059-8696
History 
  • Received September 1, 2023
  • Accepted January 5, 2024
  • Published online December 30, 2024.

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  • Previous version (February 8, 2024 - 20:20).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

Author Information

  1. Bernhard M Siepen1,2,
  2. Elisabeth Forfang3,4,
  3. Mattia Branca5,
  4. Boudewijn Drop1,
  5. Madlaine Mueller1,
  6. Martina B Goeldlin1,
  7. Mira Katan6,
  8. Patrik Michel7,
  9. Carlo Cereda8,
  10. Friedrich Medlin9,
  11. Nils Peters10,
  12. Susanne Renaud11,
  13. Julien Niederhauser12,
  14. Emmanuel Carrera13,
  15. Timo Kahles14,
  16. Georg Kägi1,15,
  17. Manuel Bolognese16,
  18. Stephan Salmen17,
  19. Marie-Luise Mono18,
  20. Alexandros A Polymeris6,
  21. Susanne Wegener19,
  22. Werner Z'Graggen1,20,
  23. Johannes Kaesmacher21,
  24. Michael Schaerer22,
  25. Biljana Rodic23,
  26. Espen Saxhaug Kristoffersen24,25,
  27. Kristin T Larsen3,4,24,
  28. Torgeir Bruun Wyller3,4,
  29. Bastian Volbers1,
  30. Thomas R Meinel1,
  31. Marcel Arnold1,
  32. Stefan T Engelter6,26,
  33. Leo H Bonati6,27,
  34. Urs Fischer1,6,
  35. Ole Morten Rønning3,24,
  36. David J Seiffge1
  1. 1 Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
  2. 2 Graduate School for Health Sciences, University of Bern, Bern, Switzerland
  3. 3 Institute of Clinical Medicine, University of Oslo, Oslo, Norway
  4. 4 Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway
  5. 5 CTU Bern, Department of Clinical Research, University of Bern, Bern, Switzerland
  6. 6 Department of Neurology, University Hospital Basel, University of Basel, Basel, Switzerland
  7. 7 Service of Neurology, Department of Clinical Neurosciences, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland
  8. 8 Stroke Center EOC, Neurocenter of Southern Switzerland, Lugano, Switzerland
  9. 9 Stroke Unit and Division of Neurology, HFR Fribourg–Cantonal Hospital, Fribourg, Switzerland
  10. 10 Stroke Center Hirslanden, Klinik Hirslanden Zurich, Zurich, Switzerland
  11. 11 Division of Neurology, Pourtalès Hospital, Neuchatel, Switzerland
  12. 12 Stroke Unit, GHOL, Hospital Nyon, Nyon, Switzerland
  13. 13 Stroke Research Group, Department of Clinical Neurosciences, Geneva University Hospital, Faculty of Medicine, University of Geneva, Geneva, Switzerland
  14. 14 Department of Neurology, Cantonal Hospital Aarau, Aarau, Switzerland
  15. 15 Department of Neurology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland
  16. 16 Neurology Department, Lucerne Cantonal Hospital (LUKS), Luzern, Switzerland
  17. 17 Stroke Unit, Department of Neurology, Hospital Biel, Biel, Switzerland
  18. 18 Department of Neurology, Stadtspitäler Triemli und Waid, Zurich, Switzerland
  19. 19 Department of Neurology and Stroke Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland
  20. 20 Department of Neurosurgery, Inselspital, Bern University Hospital, Bern, Switzerland
  21. 21 University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
  22. 22 Department of Neurology, Bürgerspital Solothurn, Solothurn, Switzerland
  23. 23 Stroke Unit, Department of Neurology, Cantonal Hospital Winterthur, Winterthur, Switzerland
  24. 24 Department of Neurology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway
  25. 25 Department of General Practice, University of Oslo, Oslo, Norway
  26. 26 Department of Neurology and Neurorehabilitation, University of Basel; University Department of Geriatric Medicine Felix Platter, University of Basel, Basel, Switzerland
  27. 27 Rehabilitation Clinic Rheinfelden, Rheinfelden, Switzerland
  1. Correspondence to Dr David J Seiffge; david.seiffge{at}insel.ch
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Intracerebral haemorrhage in patients taking different types of oral anticoagulants: a pooled individual patient data analysis from two national stroke registries
Bernhard M Siepen, Elisabeth Forfang, Mattia Branca, Boudewijn Drop, Madlaine Mueller, Martina B Goeldlin, Mira Katan, Patrik Michel, Carlo Cereda, Friedrich Medlin, Nils Peters, Susanne Renaud, Julien Niederhauser, Emmanuel Carrera, Timo Kahles, Georg Kägi, Manuel Bolognese, Stephan Salmen, Marie-Luise Mono, Alexandros A Polymeris, Susanne Wegener, Werner Z'Graggen, Johannes Kaesmacher, Michael Schaerer, Biljana Rodic, Espen Saxhaug Kristoffersen, Kristin T Larsen, Torgeir Bruun Wyller, Bastian Volbers, Thomas R Meinel, Marcel Arnold, Stefan T Engelter, Leo H Bonati, Urs Fischer, Ole Morten Rønning, David J Seiffge
Stroke and Vascular Neurology Dec 2024, 9 (6) 640-651; DOI: 10.1136/svn-2023-002813

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Intracerebral haemorrhage in patients taking different types of oral anticoagulants: a pooled individual patient data analysis from two national stroke registries
Bernhard M Siepen, Elisabeth Forfang, Mattia Branca, Boudewijn Drop, Madlaine Mueller, Martina B Goeldlin, Mira Katan, Patrik Michel, Carlo Cereda, Friedrich Medlin, Nils Peters, Susanne Renaud, Julien Niederhauser, Emmanuel Carrera, Timo Kahles, Georg Kägi, Manuel Bolognese, Stephan Salmen, Marie-Luise Mono, Alexandros A Polymeris, Susanne Wegener, Werner Z'Graggen, Johannes Kaesmacher, Michael Schaerer, Biljana Rodic, Espen Saxhaug Kristoffersen, Kristin T Larsen, Torgeir Bruun Wyller, Bastian Volbers, Thomas R Meinel, Marcel Arnold, Stefan T Engelter, Leo H Bonati, Urs Fischer, Ole Morten Rønning, David J Seiffge
Stroke and Vascular Neurology Dec 2024, 9 (6) 640-651; DOI: 10.1136/svn-2023-002813
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Intracerebral haemorrhage in patients taking different types of oral anticoagulants: a pooled individual patient data analysis from two national stroke registries
Bernhard M Siepen, Elisabeth Forfang, Mattia Branca, Boudewijn Drop, Madlaine Mueller, Martina B Goeldlin, Mira Katan, Patrik Michel, Carlo Cereda, Friedrich Medlin, Nils Peters, Susanne Renaud, Julien Niederhauser, Emmanuel Carrera, Timo Kahles, Georg Kägi, Manuel Bolognese, Stephan Salmen, Marie-Luise Mono, Alexandros A Polymeris, Susanne Wegener, Werner Z'Graggen, Johannes Kaesmacher, Michael Schaerer, Biljana Rodic, Espen Saxhaug Kristoffersen, Kristin T Larsen, Torgeir Bruun Wyller, Bastian Volbers, Thomas R Meinel, Marcel Arnold, Stefan T Engelter, Leo H Bonati, Urs Fischer, Ole Morten Rønning, David J Seiffge
Stroke and Vascular Neurology Dec 2024, 9 (6) 640-651; DOI: 10.1136/svn-2023-002813
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