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Open Access

Tenecteplase thrombolysis for stroke up to 24 hours after onset with perfusion imaging selection: the umbrella phase IIa CHABLIS-T randomised clinical trial

Xin Cheng, Lan Hong, Leonid Churilov, Longting Lin, Yifeng Ling, Jin Zhang, Jianhong Yang, Yu Geng, Danhong Wu, Xueyuan Liu, Xiaoyu Zhou, Yuwu Zhao, Qijin Zhai, Liandong Zhao, Yangmei Chen, Ying Guo, Xiaofei Yu, Fan Gong, Yi Sui, Gang Li, Lumeng Yang, Hong-Qiu Gu, Yilong Wang, Mark Parsons, Qiang Dong
DOI: 10.1136/svn-2023-002820 Published 5 November 2024
Xin Cheng
1 Department of Neurology, National Center for Neurological Disorders, National Clinical Research Centre for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China
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  • ORCID record for Xin Cheng
Lan Hong
1 Department of Neurology, National Center for Neurological Disorders, National Clinical Research Centre for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China
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Leonid Churilov
2 Melbourne Medical School, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
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Longting Lin
3 University of New South Wales South Western Sydney Clinical School, Ingham Institute for Applied Medical Research, Department of Neurology, Liverpool Hospital, Sydney, New South Wales, Australia
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Yifeng Ling
1 Department of Neurology, National Center for Neurological Disorders, National Clinical Research Centre for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China
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Jin Zhang
4 Department of Neurology, the First Hospital of Shanxi Medical University, Taiyuan, China
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Jianhong Yang
5 Department of Neurology, Ningbo First Hospital, Ningbo, China
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Yu Geng
6 Center for Rehabilitation Medicine, Department of Neurology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, China
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Danhong Wu
7 Department of Neurology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China
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  • ORCID record for Danhong Wu
Xueyuan Liu
8 Department of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
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Xiaoyu Zhou
8 Department of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
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Yuwu Zhao
9 Department of Neurology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Qijin Zhai
10 Department of Neurology, Xuzhou Medical University Affiliated Hospital of Huaian, Huaian, China
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Liandong Zhao
10 Department of Neurology, Xuzhou Medical University Affiliated Hospital of Huaian, Huaian, China
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Yangmei Chen
11 Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Ying Guo
12 Department of Neurology, Pu'er People's Hospital, Pu'er, China
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Xiaofei Yu
13 Department of Neurology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
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Fan Gong
13 Department of Neurology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
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Yi Sui
14 Department of Neurology, Shenyang First People's Hospital, Shenyang Medical College Affiliated Brain Hospital, Shenyang, China
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Gang Li
15 Department of Neurology, Shanghai East Hospital, Tongji University, Shanghai, China
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Lumeng Yang
1 Department of Neurology, National Center for Neurological Disorders, National Clinical Research Centre for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China
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Hong-Qiu Gu
16 China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China
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Yilong Wang
16 China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China
17 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Mark Parsons
3 University of New South Wales South Western Sydney Clinical School, Ingham Institute for Applied Medical Research, Department of Neurology, Liverpool Hospital, Sydney, New South Wales, Australia
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Qiang Dong
1 Department of Neurology, National Center for Neurological Disorders, National Clinical Research Centre for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China
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Article Information

vol. 9 no. 5 551-559
DOI 
https://doi.org/10.1136/svn-2023-002820
PubMed 
38286484

Print ISSN 
2059-8688
Online ISSN 
2059-8696
History 
  • Received September 4, 2023
  • Accepted December 14, 2023
  • Published online November 5, 2024.

Article Versions

  • Previous version (January 29, 2024 - 06:24).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

Author Information

  1. Xin Cheng1,
  2. Lan Hong1,
  3. Leonid Churilov2,
  4. Longting Lin3,
  5. Yifeng Ling1,
  6. Jin Zhang4,
  7. Jianhong Yang5,
  8. Yu Geng6,
  9. Danhong Wu7,
  10. Xueyuan Liu8,
  11. Xiaoyu Zhou8,
  12. Yuwu Zhao9,
  13. Qijin Zhai10,
  14. Liandong Zhao10,
  15. Yangmei Chen11,
  16. Ying Guo12,
  17. Xiaofei Yu13,
  18. Fan Gong13,
  19. Yi Sui14,
  20. Gang Li15,
  21. Lumeng Yang1,
  22. Hong-Qiu Gu16,
  23. Yilong Wang16,17,
  24. Mark Parsons3,
  25. Qiang Dong1
  26. the CHABLIS-T collaborators
  1. 1 Department of Neurology, National Center for Neurological Disorders, National Clinical Research Centre for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China
  2. 2 Melbourne Medical School, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
  3. 3 University of New South Wales South Western Sydney Clinical School, Ingham Institute for Applied Medical Research, Department of Neurology, Liverpool Hospital, Sydney, New South Wales, Australia
  4. 4 Department of Neurology, the First Hospital of Shanxi Medical University, Taiyuan, China
  5. 5 Department of Neurology, Ningbo First Hospital, Ningbo, China
  6. 6 Center for Rehabilitation Medicine, Department of Neurology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, China
  7. 7 Department of Neurology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China
  8. 8 Department of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
  9. 9 Department of Neurology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
  10. 10 Department of Neurology, Xuzhou Medical University Affiliated Hospital of Huaian, Huaian, China
  11. 11 Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
  12. 12 Department of Neurology, Pu'er People's Hospital, Pu'er, China
  13. 13 Department of Neurology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
  14. 14 Department of Neurology, Shenyang First People's Hospital, Shenyang Medical College Affiliated Brain Hospital, Shenyang, China
  15. 15 Department of Neurology, Shanghai East Hospital, Tongji University, Shanghai, China
  16. 16 China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China
  17. 17 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
  1. Correspondence to Dr Qiang Dong; qiang_dong163{at}163.com
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Tenecteplase thrombolysis for stroke up to 24 hours after onset with perfusion imaging selection: the umbrella phase IIa CHABLIS-T randomised clinical trial
Xin Cheng, Lan Hong, Leonid Churilov, Longting Lin, Yifeng Ling, Jin Zhang, Jianhong Yang, Yu Geng, Danhong Wu, Xueyuan Liu, Xiaoyu Zhou, Yuwu Zhao, Qijin Zhai, Liandong Zhao, Yangmei Chen, Ying Guo, Xiaofei Yu, Fan Gong, Yi Sui, Gang Li, Lumeng Yang, Hong-Qiu Gu, Yilong Wang, Mark Parsons, Qiang Dong
Stroke and Vascular Neurology Oct 2024, 9 (5) 551-559; DOI: 10.1136/svn-2023-002820

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Tenecteplase thrombolysis for stroke up to 24 hours after onset with perfusion imaging selection: the umbrella phase IIa CHABLIS-T randomised clinical trial
Xin Cheng, Lan Hong, Leonid Churilov, Longting Lin, Yifeng Ling, Jin Zhang, Jianhong Yang, Yu Geng, Danhong Wu, Xueyuan Liu, Xiaoyu Zhou, Yuwu Zhao, Qijin Zhai, Liandong Zhao, Yangmei Chen, Ying Guo, Xiaofei Yu, Fan Gong, Yi Sui, Gang Li, Lumeng Yang, Hong-Qiu Gu, Yilong Wang, Mark Parsons, Qiang Dong
Stroke and Vascular Neurology Oct 2024, 9 (5) 551-559; DOI: 10.1136/svn-2023-002820
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Tenecteplase thrombolysis for stroke up to 24 hours after onset with perfusion imaging selection: the umbrella phase IIa CHABLIS-T randomised clinical trial
Xin Cheng, Lan Hong, Leonid Churilov, Longting Lin, Yifeng Ling, Jin Zhang, Jianhong Yang, Yu Geng, Danhong Wu, Xueyuan Liu, Xiaoyu Zhou, Yuwu Zhao, Qijin Zhai, Liandong Zhao, Yangmei Chen, Ying Guo, Xiaofei Yu, Fan Gong, Yi Sui, Gang Li, Lumeng Yang, Hong-Qiu Gu, Yilong Wang, Mark Parsons, Qiang Dong
Stroke and Vascular Neurology Oct 2024, 9 (5) 551-559; DOI: 10.1136/svn-2023-002820
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