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Open Access

Efficacy and safety of dual antiplatelet therapy in the elderly for stroke prevention: a subgroup analysis of the CHANCE-2 trial

Xinmiao Zhang, Jing Jing, Anxin Wang, Xuewei Xie, S Claiborne Johnston, Hao Li, Philip M Bath, Qin Xu, Jinxi Lin, Yilong Wang, Xingquan Zhao, Zixiao Li, Yong Jiang, Liping Liu, Weifeng Chen, Xuhai Gong, Jianhua Li, Xinsheng Han, Xia Meng, Yongjun Wang
DOI: 10.1136/svn-2023-002450 Published 5 November 2024
Xinmiao Zhang
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
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Jing Jing
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
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Anxin Wang
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
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Xuewei Xie
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
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S Claiborne Johnston
3 Dell Medical School, University of Texas at Austin, Austin, Texas, USA
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Hao Li
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
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Philip M Bath
4 Stroke Trials Unit, Mental Health & Clinical Neuroscience, University of Nottingham, Nottingham, UK
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Qin Xu
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
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Jinxi Lin
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
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Yilong Wang
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
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Xingquan Zhao
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
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Zixiao Li
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
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Yong Jiang
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
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Liping Liu
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
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Weifeng Chen
5 Department of Neurology, Xingyang People's Hospital, Henan, China
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Xuhai Gong
6 Daqing Oilfield General Hospital, Daqing, Heilongjiang, China
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Jianhua Li
7 The First Hospital of Fangshan District, Beijing, China
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Xinsheng Han
8 Kaifeng Central Hospital, Henan, China
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Xia Meng
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
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Yongjun Wang
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
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Article Information

vol. 9 no. 5 541-550
DOI 
https://doi.org/10.1136/svn-2023-002450
PubMed 
38286485

Print ISSN 
2059-8688
Online ISSN 
2059-8696
History 
  • Received March 6, 2023
  • Accepted December 16, 2023
  • Published online November 5, 2024.

Article Versions

  • Previous version (January 29, 2024 - 06:24).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

Author Information

  1. Xinmiao Zhang1,2,
  2. Jing Jing1,2,
  3. Anxin Wang1,2,
  4. Xuewei Xie1,2,
  5. S Claiborne Johnston3,
  6. Hao Li1,2,
  7. Philip M Bath4,
  8. Qin Xu2,
  9. Jinxi Lin2,
  10. Yilong Wang1,2,
  11. Xingquan Zhao1,2,
  12. Zixiao Li1,2,
  13. Yong Jiang1,2,
  14. Liping Liu1,2,
  15. Weifeng Chen5,
  16. Xuhai Gong6,
  17. Jianhua Li7,
  18. Xinsheng Han8,
  19. Xia Meng1,2,
  20. Yongjun Wang1,2
  1. 1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
  2. 2 China National Clinical Research Center for Neurological Diseases, Beijing, China
  3. 3 Dell Medical School, University of Texas at Austin, Austin, Texas, USA
  4. 4 Stroke Trials Unit, Mental Health & Clinical Neuroscience, University of Nottingham, Nottingham, UK
  5. 5 Department of Neurology, Xingyang People's Hospital, Henan, China
  6. 6 Daqing Oilfield General Hospital, Daqing, Heilongjiang, China
  7. 7 The First Hospital of Fangshan District, Beijing, China
  8. 8 Kaifeng Central Hospital, Henan, China
  1. Correspondence to Dr Yongjun Wang; yongjunwang{at}ncrcnd.org.cn
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Efficacy and safety of dual antiplatelet therapy in the elderly for stroke prevention: a subgroup analysis of the CHANCE-2 trial
Xinmiao Zhang, Jing Jing, Anxin Wang, Xuewei Xie, S Claiborne Johnston, Hao Li, Philip M Bath, Qin Xu, Jinxi Lin, Yilong Wang, Xingquan Zhao, Zixiao Li, Yong Jiang, Liping Liu, Weifeng Chen, Xuhai Gong, Jianhua Li, Xinsheng Han, Xia Meng, Yongjun Wang
Stroke and Vascular Neurology Oct 2024, 9 (5) 541-550; DOI: 10.1136/svn-2023-002450

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Efficacy and safety of dual antiplatelet therapy in the elderly for stroke prevention: a subgroup analysis of the CHANCE-2 trial
Xinmiao Zhang, Jing Jing, Anxin Wang, Xuewei Xie, S Claiborne Johnston, Hao Li, Philip M Bath, Qin Xu, Jinxi Lin, Yilong Wang, Xingquan Zhao, Zixiao Li, Yong Jiang, Liping Liu, Weifeng Chen, Xuhai Gong, Jianhua Li, Xinsheng Han, Xia Meng, Yongjun Wang
Stroke and Vascular Neurology Oct 2024, 9 (5) 541-550; DOI: 10.1136/svn-2023-002450
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Efficacy and safety of dual antiplatelet therapy in the elderly for stroke prevention: a subgroup analysis of the CHANCE-2 trial
Xinmiao Zhang, Jing Jing, Anxin Wang, Xuewei Xie, S Claiborne Johnston, Hao Li, Philip M Bath, Qin Xu, Jinxi Lin, Yilong Wang, Xingquan Zhao, Zixiao Li, Yong Jiang, Liping Liu, Weifeng Chen, Xuhai Gong, Jianhua Li, Xinsheng Han, Xia Meng, Yongjun Wang
Stroke and Vascular Neurology Oct 2024, 9 (5) 541-550; DOI: 10.1136/svn-2023-002450
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