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Open Access

Prehospital transdermal glyceryl trinitrate for ultra-acute ischaemic stroke: data from the RIGHT-2 randomised sham-controlled ambulance trial

Jason Philip Appleton, Lisa J Woodhouse, Craig S Anderson, Sandeep Ankolekar, Lesley Cala, Mark Dixon, Timothy J England, Kailash Krishnan, Grant Mair, Keith W Muir, John Potter, Christopher I Price, Marc Randall, Thompson G Robinson, Christine Roffe, Else C Sandset, Jeffrey L Saver, Angela Shone, Aloysius Niroshan Siriwardena, Joanna M Wardlaw, Nikola Sprigg, Philip M Bath
DOI: 10.1136/svn-2022-001634 Published 27 February 2024
Jason Philip Appleton
1 Stroke, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
2 Institute of Applied Health Research, University of Birmingham College of Medical and Dental Sciences, Birmingham, UK
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Lisa J Woodhouse
3 Stroke Trials Unit, Mental Health and Clinical Neurosciences, University of Nottingham, Nottingham, UK
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Craig S Anderson
4 Faculty of Medicine, The George Institute for Global Health, Sydney, New South Wales, Australia
5 The George Institute China at Peking University Health Science Center, Beijing, China
6 Neurology, Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, New South Wales, Australia
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Sandeep Ankolekar
7 Department of Neurology, King's College Hospital NHS Foundation Trust, London, UK
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Lesley Cala
8 Faculty of Health and Medical Sciences, University of Western Australia, Crawley, Western Australia, Australia
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Mark Dixon
3 Stroke Trials Unit, Mental Health and Clinical Neurosciences, University of Nottingham, Nottingham, UK
9 East Midlands Ambulance Service NHS Trust, Nottingham, UK
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Timothy J England
3 Stroke Trials Unit, Mental Health and Clinical Neurosciences, University of Nottingham, Nottingham, UK
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Kailash Krishnan
10 Stroke, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK
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Grant Mair
11 Centre for Clinical Brain Sciences, Dementia Research Institute, Univeristy of Edinburgh, Edinburgh, UK
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Keith W Muir
12 Institute of Neurology and Psychology, University of Glasgow, Glasgow, UK
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John Potter
13 Bob Champion Research and Education Building, University of East Anglia, Norwich, UK
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Christopher I Price
14 Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK
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Marc Randall
15 Department of Neurology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
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Thompson G Robinson
16 Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK
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Christine Roffe
17 Stroke Research in Stoke, Institute for Science and Technology in Medicine, Keele University, Stoke-on-Trent, UK
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Else C Sandset
18 Department of Neurology, Oslo University Hospital, Oslo, Norway
19 Research and Development, Norwegian Air Ambulance Foundation, Oslo, Norway
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Jeffrey L Saver
20 Department of Neurology and Comprehensive Stroke Center, David Geffen School of Medicine, UCLA, Los Angeles, California, USA
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Angela Shone
21 Research and Graduate Services, University of Nottingham, Nottingham, UK
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Aloysius Niroshan Siriwardena
9 East Midlands Ambulance Service NHS Trust, Nottingham, UK
22 Community and Health Research Unit, University of Lincoln, Lincoln, UK
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Joanna M Wardlaw
11 Centre for Clinical Brain Sciences, Dementia Research Institute, Univeristy of Edinburgh, Edinburgh, UK
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Nikola Sprigg
3 Stroke Trials Unit, Mental Health and Clinical Neurosciences, University of Nottingham, Nottingham, UK
10 Stroke, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK
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Philip M Bath
3 Stroke Trials Unit, Mental Health and Clinical Neurosciences, University of Nottingham, Nottingham, UK
10 Stroke, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK
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Article Information

vol. 9 no. 1 38-49
DOI 
https://doi.org/10.1136/svn-2022-001634
PubMed 
37290930

Print ISSN 
2059-8688
Online ISSN 
2059-8696
History 
  • Received April 14, 2022
  • Accepted August 12, 2022
  • Published online February 27, 2024.

Article Versions

  • Previous version (June 8, 2023 - 09:01).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

Author Information

  1. Jason Philip Appleton1,2,
  2. Lisa J Woodhouse3,
  3. Craig S Anderson4,5,6,
  4. Sandeep Ankolekar7,
  5. Lesley Cala8,
  6. Mark Dixon3,9,
  7. Timothy J England3,
  8. Kailash Krishnan10,
  9. Grant Mair11,
  10. Keith W Muir12,
  11. John Potter13,
  12. Christopher I Price14,
  13. Marc Randall15,
  14. Thompson G Robinson16,
  15. Christine Roffe17,
  16. Else C Sandset18,19,
  17. Jeffrey L Saver20,
  18. Angela Shone21,
  19. Aloysius Niroshan Siriwardena9,22,
  20. Joanna M Wardlaw11,
  21. Nikola Sprigg3,10,
  22. Philip M Bath3,10
  23. On behalf of the RIGHT-2 Investigators
  1. 1 Stroke, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
  2. 2 Institute of Applied Health Research, University of Birmingham College of Medical and Dental Sciences, Birmingham, UK
  3. 3 Stroke Trials Unit, Mental Health and Clinical Neurosciences, University of Nottingham, Nottingham, UK
  4. 4 Faculty of Medicine, The George Institute for Global Health, Sydney, New South Wales, Australia
  5. 5 The George Institute China at Peking University Health Science Center, Beijing, China
  6. 6 Neurology, Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, New South Wales, Australia
  7. 7 Department of Neurology, King's College Hospital NHS Foundation Trust, London, UK
  8. 8 Faculty of Health and Medical Sciences, University of Western Australia, Crawley, Western Australia, Australia
  9. 9 East Midlands Ambulance Service NHS Trust, Nottingham, UK
  10. 10 Stroke, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK
  11. 11 Centre for Clinical Brain Sciences, Dementia Research Institute, Univeristy of Edinburgh, Edinburgh, UK
  12. 12 Institute of Neurology and Psychology, University of Glasgow, Glasgow, UK
  13. 13 Bob Champion Research and Education Building, University of East Anglia, Norwich, UK
  14. 14 Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK
  15. 15 Department of Neurology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
  16. 16 Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK
  17. 17 Stroke Research in Stoke, Institute for Science and Technology in Medicine, Keele University, Stoke-on-Trent, UK
  18. 18 Department of Neurology, Oslo University Hospital, Oslo, Norway
  19. 19 Research and Development, Norwegian Air Ambulance Foundation, Oslo, Norway
  20. 20 Department of Neurology and Comprehensive Stroke Center, David Geffen School of Medicine, UCLA, Los Angeles, California, USA
  21. 21 Research and Graduate Services, University of Nottingham, Nottingham, UK
  22. 22 Community and Health Research Unit, University of Lincoln, Lincoln, UK
  1. Correspondence to Professor Philip M Bath; philip.bath{at}nottingham.ac.uk
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Prehospital transdermal glyceryl trinitrate for ultra-acute ischaemic stroke: data from the RIGHT-2 randomised sham-controlled ambulance trial
Jason Philip Appleton, Lisa J Woodhouse, Craig S Anderson, Sandeep Ankolekar, Lesley Cala, Mark Dixon, Timothy J England, Kailash Krishnan, Grant Mair, Keith W Muir, John Potter, Christopher I Price, Marc Randall, Thompson G Robinson, Christine Roffe, Else C Sandset, Jeffrey L Saver, Angela Shone, Aloysius Niroshan Siriwardena, Joanna M Wardlaw, Nikola Sprigg, Philip M Bath
Stroke and Vascular Neurology Feb 2024, 9 (1) 38-49; DOI: 10.1136/svn-2022-001634

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Prehospital transdermal glyceryl trinitrate for ultra-acute ischaemic stroke: data from the RIGHT-2 randomised sham-controlled ambulance trial
Jason Philip Appleton, Lisa J Woodhouse, Craig S Anderson, Sandeep Ankolekar, Lesley Cala, Mark Dixon, Timothy J England, Kailash Krishnan, Grant Mair, Keith W Muir, John Potter, Christopher I Price, Marc Randall, Thompson G Robinson, Christine Roffe, Else C Sandset, Jeffrey L Saver, Angela Shone, Aloysius Niroshan Siriwardena, Joanna M Wardlaw, Nikola Sprigg, Philip M Bath
Stroke and Vascular Neurology Feb 2024, 9 (1) 38-49; DOI: 10.1136/svn-2022-001634
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Prehospital transdermal glyceryl trinitrate for ultra-acute ischaemic stroke: data from the RIGHT-2 randomised sham-controlled ambulance trial
Jason Philip Appleton, Lisa J Woodhouse, Craig S Anderson, Sandeep Ankolekar, Lesley Cala, Mark Dixon, Timothy J England, Kailash Krishnan, Grant Mair, Keith W Muir, John Potter, Christopher I Price, Marc Randall, Thompson G Robinson, Christine Roffe, Else C Sandset, Jeffrey L Saver, Angela Shone, Aloysius Niroshan Siriwardena, Joanna M Wardlaw, Nikola Sprigg, Philip M Bath
Stroke and Vascular Neurology Feb 2024, 9 (1) 38-49; DOI: 10.1136/svn-2022-001634
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