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Safety and efficacy of tenecteplase versus alteplase in patients with acute ischaemic stroke (TRACE): a multicentre, randomised, open label, blinded-endpoint (PROBE) controlled phase II study

Shuya Li, Yuesong Pan, Ziran Wang, Zhigang Liang, Huisheng Chen, Dong Wang, Yi Sui, Xingquan Zhao, Yilong Wang, WanLiang Du, Huaguang Zheng, Yongjun Wang
DOI: 10.1136/svn-2021-000978 Published 25 February 2022
Shuya Li
1 China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China
2 Department of Neurology, Beijing Tiantan Hospital, Beijing, China
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Yuesong Pan
1 China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China
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Ziran Wang
3 Department of Neurology, Linyi People's Hospital, Linyi, China
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Zhigang Liang
4 Department of Neurology, Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College, YanTai, China
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Huisheng Chen
5 Department of Neurology, General Hospital of Northern Theatre Command, Shenyang, Liaoning, China
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Dong Wang
6 Department of Neurology, Baogang Hospital of Inner Monglia, Inner Monglia, China
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Yi Sui
7 Department of Neurology, The First People’s Hospital of Shenyang, Shenyang, China
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Xingquan Zhao
8 Neurology, Beijing Tiantan Hospital, Beijing, China
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Yilong Wang
8 Neurology, Beijing Tiantan Hospital, Beijing, China
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WanLiang Du
2 Department of Neurology, Beijing Tiantan Hospital, Beijing, China
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Huaguang Zheng
8 Neurology, Beijing Tiantan Hospital, Beijing, China
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Yongjun Wang
1 China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China
2 Department of Neurology, Beijing Tiantan Hospital, Beijing, China
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Article Information

vol. 7 no. 1 47-53
DOI 
https://doi.org/10.1136/svn-2021-000978
PubMed 
34429364

Print ISSN 
2059-8688
Online ISSN 
2059-8696
History 
  • Received March 5, 2021
  • Accepted August 2, 2021
  • Published online February 25, 2022.

Article Versions

  • Previous version (August 24, 2021 - 08:07).
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Copyright & Usage 
© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

Author Information

  1. Shuya Li1,2,
  2. Yuesong Pan1,
  3. Ziran Wang3,
  4. Zhigang Liang4,
  5. Huisheng Chen5,
  6. Dong Wang6,
  7. Yi Sui7,
  8. Xingquan Zhao8,
  9. Yilong Wang8,
  10. WanLiang Du2,
  11. Huaguang Zheng8,
  12. Yongjun Wang1,2
  1. 1 China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China
  2. 2 Department of Neurology, Beijing Tiantan Hospital, Beijing, China
  3. 3 Department of Neurology, Linyi People's Hospital, Linyi, China
  4. 4 Department of Neurology, Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College, YanTai, China
  5. 5 Department of Neurology, General Hospital of Northern Theatre Command, Shenyang, Liaoning, China
  6. 6 Department of Neurology, Baogang Hospital of Inner Monglia, Inner Monglia, China
  7. 7 Department of Neurology, The First People’s Hospital of Shenyang, Shenyang, China
  8. 8 Neurology, Beijing Tiantan Hospital, Beijing, China
  1. Correspondence to Dr Yongjun Wang; yongjunwang{at}ncrcnd.org.cn
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Vol 7 Issue 1 Table of Contents
Stroke and Vascular Neurology: 7 (1)
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Safety and efficacy of tenecteplase versus alteplase in patients with acute ischaemic stroke (TRACE): a multicentre, randomised, open label, blinded-endpoint (PROBE) controlled phase II study
Shuya Li, Yuesong Pan, Ziran Wang, Zhigang Liang, Huisheng Chen, Dong Wang, Yi Sui, Xingquan Zhao, Yilong Wang, WanLiang Du, Huaguang Zheng, Yongjun Wang
Stroke and Vascular Neurology Feb 2022, 7 (1) 47-53; DOI: 10.1136/svn-2021-000978

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Safety and efficacy of tenecteplase versus alteplase in patients with acute ischaemic stroke (TRACE): a multicentre, randomised, open label, blinded-endpoint (PROBE) controlled phase II study
Shuya Li, Yuesong Pan, Ziran Wang, Zhigang Liang, Huisheng Chen, Dong Wang, Yi Sui, Xingquan Zhao, Yilong Wang, WanLiang Du, Huaguang Zheng, Yongjun Wang
Stroke and Vascular Neurology Feb 2022, 7 (1) 47-53; DOI: 10.1136/svn-2021-000978
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Safety and efficacy of tenecteplase versus alteplase in patients with acute ischaemic stroke (TRACE): a multicentre, randomised, open label, blinded-endpoint (PROBE) controlled phase II study
Shuya Li, Yuesong Pan, Ziran Wang, Zhigang Liang, Huisheng Chen, Dong Wang, Yi Sui, Xingquan Zhao, Yilong Wang, WanLiang Du, Huaguang Zheng, Yongjun Wang
Stroke and Vascular Neurology Feb 2022, 7 (1) 47-53; DOI: 10.1136/svn-2021-000978
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