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Multicentre prospective, randomised open-label, endpoint-blinded study to evaluate the safety and efficacy of propranolol for the prevention of stroke-associated pneumonia in patients with intracerebral haemorrhage (PROCHASE): rationale and design

Bin Gao, Kaibin Shi, Yuesong Pan, Shunnan Ge, Yanfang Liu, Jing Yan, Arthur Liesz, Andreas Meisel, Yan Qu, Xingquan Zhao, Fu-Dong Shi
DOI: 10.1136/svn-2024-003630 Published 31 December 2024
Bin Gao
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Kaibin Shi
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Yuesong Pan
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Shunnan Ge
3Department of Neurosurgery, Tangdu Hospital Fourth Military Medical University, Xi'an, China
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Yanfang Liu
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Jing Yan
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Arthur Liesz
4Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
5Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
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Andreas Meisel
6Department of Neurology with Experimental Neurology, Neuroscience Clinical Research Center, Charité Universitätsmedizin Berlin, Berlin, Germany
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  • ORCID record for Andreas Meisel
Yan Qu
3Department of Neurosurgery, Tangdu Hospital Fourth Military Medical University, Xi'an, China
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Xingquan Zhao
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Fu-Dong Shi
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
7Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China
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Article Information

DOI 
https://doi.org/10.1136/svn-2024-003630
PubMed 
39740854

Print ISSN 
2059-8688
Online ISSN 
2059-8696
History 
  • Received August 16, 2024
  • Accepted December 17, 2024
  • Published online December 31, 2024.

Copyright & Usage 
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

Author Information

  1. Bin Gao1,2,
  2. Kaibin Shi1,2,
  3. Yuesong Pan1,2,
  4. Shunnan Ge3,
  5. Yanfang Liu1,2,
  6. Jing Yan1,2,
  7. Arthur Liesz4,5,
  8. Andreas Meisel6,
  9. Yan Qu3,
  10. Xingquan Zhao1,2,
  11. Fu-Dong Shi1,2,7
  1. 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
  2. 2China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
  3. 3Department of Neurosurgery, Tangdu Hospital Fourth Military Medical University, Xi'an, China
  4. 4Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
  5. 5Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
  6. 6Department of Neurology with Experimental Neurology, Neuroscience Clinical Research Center, Charité Universitätsmedizin Berlin, Berlin, Germany
  7. 7Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China
  1. Correspondence to Dr Fu-Dong Shi; fshi{at}tmu.edu.cn; Professor Xingquan Zhao; zxq{at}vip.163.com
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Multicentre prospective, randomised open-label, endpoint-blinded study to evaluate the safety and efficacy of propranolol for the prevention of stroke-associated pneumonia in patients with intracerebral haemorrhage (PROCHASE): rationale and design
Bin Gao, Kaibin Shi, Yuesong Pan, Shunnan Ge, Yanfang Liu, Jing Yan, Arthur Liesz, Andreas Meisel, Yan Qu, Xingquan Zhao, Fu-Dong Shi
Stroke and Vascular Neurology Dec 2024, svn-2024-003630; DOI: 10.1136/svn-2024-003630

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Multicentre prospective, randomised open-label, endpoint-blinded study to evaluate the safety and efficacy of propranolol for the prevention of stroke-associated pneumonia in patients with intracerebral haemorrhage (PROCHASE): rationale and design
Bin Gao, Kaibin Shi, Yuesong Pan, Shunnan Ge, Yanfang Liu, Jing Yan, Arthur Liesz, Andreas Meisel, Yan Qu, Xingquan Zhao, Fu-Dong Shi
Stroke and Vascular Neurology Dec 2024, svn-2024-003630; DOI: 10.1136/svn-2024-003630
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Multicentre prospective, randomised open-label, endpoint-blinded study to evaluate the safety and efficacy of propranolol for the prevention of stroke-associated pneumonia in patients with intracerebral haemorrhage (PROCHASE): rationale and design
Bin Gao, Kaibin Shi, Yuesong Pan, Shunnan Ge, Yanfang Liu, Jing Yan, Arthur Liesz, Andreas Meisel, Yan Qu, Xingquan Zhao, Fu-Dong Shi
Stroke and Vascular Neurology Dec 2024, svn-2024-003630; DOI: 10.1136/svn-2024-003630
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