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Open Access

Intra-arterial tenecteplase after successful endovascular therapy (ANGEL-TNK): protocol of a multicentre, open-label, blinded end-point, prospective, randomised trial

Xiaochuan Huo, Gang Luo, Dapeng Sun, Thanh Nguyen, Mohamad Abdalkader, Wenhuo Chen, Xiaoxi Yao, Guangxiong Yuan, Tingyu Yi, Hongxin Han, Yuesong Pan, Tudor G Jovin, David S Liebeskind, Liping Liu, Xingquan Zhao, Zeguang Ren, Yilong Wang, Yongjun Wang, Bernard Yan, Zhongrong Miao
DOI: 10.1136/svn-2024-003318 Published 21 November 2024
Xiaochuan Huo
1Cerebrovascular Disease Department, Neurological Disease Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
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Gang Luo
2Interventional Neuroradiology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
3China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Dapeng Sun
2Interventional Neuroradiology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
3China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Thanh Nguyen
4Neurology, Radiology, Boston Medical Center, Boston, Massachusetts, USA
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Mohamad Abdalkader
4Neurology, Radiology, Boston Medical Center, Boston, Massachusetts, USA
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Wenhuo Chen
5Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China
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Xiaoxi Yao
6Department of Neurology, Affiliated Chenzhou Hospital, Southern Medical University (The First People’s Hospital of Chenzhou), The First People's Hospital of Chenzhou, Chenzhou, China
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Guangxiong Yuan
7Department of Emergency, Xiangtan Central Hospital, Xiangtan, China
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Tingyu Yi
8Department of Neurology, Zhangzhou Municipal Hospital of Fujian Province and Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, China
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Hongxin Han
9Department of Neurology, Linyi People's Hospital, Linyi, Shandong, China
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Yuesong Pan
3China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Tudor G Jovin
10Cooper Hospital University Medical Center, Camden, New Jersey, USA
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David S Liebeskind
11University of California Los Angeles, Los Angeles, California, USA
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Liping Liu
3China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
12Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Xingquan Zhao
12Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Zeguang Ren
13Department of Neurosurgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China
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Yilong Wang
3China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
12Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Yongjun Wang
3China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
12Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Bernard Yan
14Department of Neurology at Melbourne Brain Center, The University of Melbourne Medicine at Royal Melbourne Hospital, Parkville, Victoria, Australia
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Zhongrong Miao
2Interventional Neuroradiology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
3China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Article Information

DOI 
https://doi.org/10.1136/svn-2024-003318
PubMed 
39357896

Print ISSN 
2059-8688
Online ISSN 
2059-8696
History 
  • Received April 9, 2024
  • Accepted September 15, 2024
  • Published online November 21, 2024.

Article Versions

  • Previous version (October 2, 2024 - 01:14).
  • Previous version (October 17, 2024 - 15:31).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

Author Information

  1. Xiaochuan Huo1,
  2. Gang Luo2,3,
  3. Dapeng Sun2,3,
  4. Thanh Nguyen4,
  5. Mohamad Abdalkader4,
  6. Wenhuo Chen5,
  7. Xiaoxi Yao6,
  8. Guangxiong Yuan7,
  9. Tingyu Yi8,
  10. Hongxin Han9,
  11. Yuesong Pan3,
  12. Tudor G Jovin10,
  13. David S Liebeskind11,
  14. Liping Liu3,12,
  15. Xingquan Zhao12,
  16. Zeguang Ren13,
  17. Yilong Wang3,12,
  18. Yongjun Wang3,12,
  19. Bernard Yan14,
  20. Zhongrong Miao2,3
  1. 1Cerebrovascular Disease Department, Neurological Disease Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
  2. 2Interventional Neuroradiology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
  3. 3China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
  4. 4Neurology, Radiology, Boston Medical Center, Boston, Massachusetts, USA
  5. 5Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China
  6. 6Department of Neurology, Affiliated Chenzhou Hospital, Southern Medical University (The First People’s Hospital of Chenzhou), The First People's Hospital of Chenzhou, Chenzhou, China
  7. 7Department of Emergency, Xiangtan Central Hospital, Xiangtan, China
  8. 8Department of Neurology, Zhangzhou Municipal Hospital of Fujian Province and Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, China
  9. 9Department of Neurology, Linyi People's Hospital, Linyi, Shandong, China
  10. 10Cooper Hospital University Medical Center, Camden, New Jersey, USA
  11. 11University of California Los Angeles, Los Angeles, California, USA
  12. 12Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
  13. 13Department of Neurosurgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China
  14. 14Department of Neurology at Melbourne Brain Center, The University of Melbourne Medicine at Royal Melbourne Hospital, Parkville, Victoria, Australia
  1. Correspondence to Dr Zhongrong Miao; zhongrongm{at}163.com; Professor Bernard Yan; Bernard.Yan{at}mh.org.au
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Intra-arterial tenecteplase after successful endovascular therapy (ANGEL-TNK): protocol of a multicentre, open-label, blinded end-point, prospective, randomised trial
Xiaochuan Huo, Gang Luo, Dapeng Sun, Thanh Nguyen, Mohamad Abdalkader, Wenhuo Chen, Xiaoxi Yao, Guangxiong Yuan, Tingyu Yi, Hongxin Han, Yuesong Pan, Tudor G Jovin, David S Liebeskind, Liping Liu, Xingquan Zhao, Zeguang Ren, Yilong Wang, Yongjun Wang, Bernard Yan, Zhongrong Miao
Stroke and Vascular Neurology Oct 2024, svn-2024-003318; DOI: 10.1136/svn-2024-003318

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Intra-arterial tenecteplase after successful endovascular therapy (ANGEL-TNK): protocol of a multicentre, open-label, blinded end-point, prospective, randomised trial
Xiaochuan Huo, Gang Luo, Dapeng Sun, Thanh Nguyen, Mohamad Abdalkader, Wenhuo Chen, Xiaoxi Yao, Guangxiong Yuan, Tingyu Yi, Hongxin Han, Yuesong Pan, Tudor G Jovin, David S Liebeskind, Liping Liu, Xingquan Zhao, Zeguang Ren, Yilong Wang, Yongjun Wang, Bernard Yan, Zhongrong Miao
Stroke and Vascular Neurology Oct 2024, svn-2024-003318; DOI: 10.1136/svn-2024-003318
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Intra-arterial tenecteplase after successful endovascular therapy (ANGEL-TNK): protocol of a multicentre, open-label, blinded end-point, prospective, randomised trial
Xiaochuan Huo, Gang Luo, Dapeng Sun, Thanh Nguyen, Mohamad Abdalkader, Wenhuo Chen, Xiaoxi Yao, Guangxiong Yuan, Tingyu Yi, Hongxin Han, Yuesong Pan, Tudor G Jovin, David S Liebeskind, Liping Liu, Xingquan Zhao, Zeguang Ren, Yilong Wang, Yongjun Wang, Bernard Yan, Zhongrong Miao
Stroke and Vascular Neurology Oct 2024, svn-2024-003318; DOI: 10.1136/svn-2024-003318
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