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Open Access

Intensity of statin therapy after ischaemic stroke and long-term outcomes: a nationwide cohort study

Ville Kytö, Julia Åivo, Jori O Ruuskanen
DOI: 10.1136/svn-2024-003230 Published 14 June 2024
Ville Kytö
1Heart Center, Turku University Hospital and University of Turku, Turku, Finland
2Clinical Research Center, Turku University Hospital, Turku, Finland
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Julia Åivo
3Neurocenter, Department of Neurology, Turku University Hospital and University of Turku, Turku, Finland
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Jori O Ruuskanen
3Neurocenter, Department of Neurology, Turku University Hospital and University of Turku, Turku, Finland
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    Figure 1

    Intensity of initial statin therapy (high, moderate, low) after ischaemic stroke (IS) and incidences of all-cause death (A), recurrent IS (B), cardiovascular death (C) and intracerebral haemorrhage (D) in 45 512 patients. Competing risk plots in panels B–D. Please note the scale differences in y-axis.

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    Association of initial statin intensity after ischaemic stroke (IS) with 12-year outcomes. Multivariable models are adjusted for age, sex, the predetermined baseline comorbidities, recanalisation, usage of neurosurgery, other medication used after the index event and treatment in a university hospital. Secondary outcomes are analysed using competing risk modelling

    Intensity of statin therapy
    High vs moderateModerate vs lowHigh vs low
    Primary outcomeadj.HR (95% CI)P valueadj.HR (95% CI)P valueadj.HR (95% CI)P value
     All-cause death0.92 (0.87 to 0.97)0.0010.91 (0.87 to 0.95)<0.00010.83 (0.78 to 0.89)<0.0001
    Secondary outcomesadj.sHR (95% CI)P valueadj.sHR (95% CI)P valueadj.sHR (95% CI)P value
     Recurrent IS0.88 (0.82 to 0.95)0.0010.87 (0.82 to 0.93)<0.00010.77 (0.70 to 0.84)<0.0001
     Cardiovascular death0.91 (0.83 to 0.99)0.0210.87 (0.81 to 0.93)<0.00010.79 (0.71 to 0.87)<0.0001
     Intracerebral haemorrhage0.91 (0.73 to 1.14)0.4021.02 (0.84 to 1.25)0.8080.93 (0.70 to 1.23)0.619
    • adj.HR, adjusted HR; adj.sHR, adjusted subdistribution HR.

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    [svn-2024-003230supp001.pdf]

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Intensity of statin therapy after ischaemic stroke and long-term outcomes: a nationwide cohort study
Ville Kytö, Julia Åivo, Jori O Ruuskanen
Stroke and Vascular Neurology Jun 2024, svn-2024-003230; DOI: 10.1136/svn-2024-003230

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Intensity of statin therapy after ischaemic stroke and long-term outcomes: a nationwide cohort study
Ville Kytö, Julia Åivo, Jori O Ruuskanen
Stroke and Vascular Neurology Jun 2024, svn-2024-003230; DOI: 10.1136/svn-2024-003230
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Intensity of statin therapy after ischaemic stroke and long-term outcomes: a nationwide cohort study
Ville Kytö, Julia Åivo, Jori O Ruuskanen
Stroke and Vascular Neurology Jun 2024, svn-2024-003230; DOI: 10.1136/svn-2024-003230
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