Intra-arterial tenecteplase during thrombectomy for acute stroke (BRETIS-TNK II): rationale and design

Zi-Ai Zhao; Jing Qiu; Wei Li; Thanh Nguyen; Shouchun Wang; Huaizhang Shi; Ming Wei; Feng Wang; Di Li; Hui-Sheng Chen

doi:10.1136/svn-2023-002377

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Intra-arterial tenecteplase during thrombectomy for acute stroke (BRETIS-TNK II): rationale and design

Zi-Ai Zhao, Jing Qiu, Wei Li, Thanh Nguyen, Shouchun Wang, Huaizhang Shi, Ming Wei, Feng Wang, Di Li, Hui-Sheng Chen

DOI: 10.1136/svn-2023-002377 Published 11 May 2023

Zi-Ai Zhao

1Department of Neurology, General Hospital of Northern Theater Command, Shenyang, Liaoning Province, China

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Jing Qiu

1Department of Neurology, General Hospital of Northern Theater Command, Shenyang, Liaoning Province, China

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Wei Li

1Department of Neurology, General Hospital of Northern Theater Command, Shenyang, Liaoning Province, China

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Thanh Nguyen

2Neurology, Radiology, Boston Medical Center, Boston, Massachusetts, USA

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ORCID record for Thanh Nguyen

Shouchun Wang

3Department of Neurology, First Affiliated Hospital of Jilin University, Changchun, Jilin, China

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Huaizhang Shi

4Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China

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Ming Wei

5Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, Tianjin, China

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Feng Wang

6Department of Interventional Therapy, First Affiliated Hospital of Dalian Medical University, Dalian, China

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Di Li

7Neurological Intervention Department, Dalian Municipal Central Hospital, Dalian, Liaoning, China

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Hui-Sheng Chen

1Department of Neurology, General Hospital of Northern Theater Command, Shenyang, Liaoning Province, China

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Figure 1
Trial flow chart. AIS, acute ischaemic stroke; LVO, large-vessel occlusion; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; R, randomisation.
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Figure 2
Flow chart of endovascular treatment procedures. DSA, digital subtraction angiography; mTICI, Modified Treatment in Cerebral Ischaemia; TNK, tenecteplase.

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Intra-arterial tenecteplase during thrombectomy for acute stroke (BRETIS-TNK II): rationale and design

Zi-Ai Zhao, Jing Qiu, Wei Li, Thanh Nguyen, Shouchun Wang, Huaizhang Shi, Ming Wei, Feng Wang, Di Li, Hui-Sheng Chen

Stroke and Vascular Neurology May 2023, svn-2023-002377; DOI: 10.1136/svn-2023-002377

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Intra-arterial tenecteplase during thrombectomy for acute stroke (BRETIS-TNK II): rationale and design

Zi-Ai Zhao, Jing Qiu, Wei Li, Thanh Nguyen, Shouchun Wang, Huaizhang Shi, Ming Wei, Feng Wang, Di Li, Hui-Sheng Chen

Stroke and Vascular Neurology May 2023, svn-2023-002377; DOI: 10.1136/svn-2023-002377

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Intra-arterial tenecteplase during thrombectomy for acute stroke (BRETIS-TNK II): rationale and design

Zi-Ai Zhao, Jing Qiu, Wei Li, Thanh Nguyen, Shouchun Wang, Huaizhang Shi, Ming Wei, Feng Wang, Di Li, Hui-Sheng Chen

Stroke and Vascular Neurology May 2023, svn-2023-002377; DOI: 10.1136/svn-2023-002377

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