Article Figures & Data
Figures
- Figure 1
Neuroimaging features of CAA-ri. Susceptibility-weighted imaging showed multiple cerebral macrobleeds, microbleeds and superficial siderosis (A–B). 18F-florbetapir positron emission tomography revealed higher tracer retention (red) representing diffuse amyloid deposition in cerebral lobes (C–D). Baseline brain MRI showed asymmetric white matter hyperintensities beyond ICH lesions on T2-weighted images (E–F). White matter lesions in left temporal and parietal lobes resolved after corticosteroid therapy (G–H). CAA-ri, cerebral amyloid angiopathy-related inflammation; ICH, intracerebral haemorrhage.
- Figure 2
Histological and immunohistochemical features of biopsy specimen. Biopsy of the left temporal cortex. H&E staining showed perivascular cuffing with lymphocytes infiltration and fibrinoid necrosis (A), as well as haemosiderin deposition (B). Immunohistochemical staining for amyloid-beta showed severe amyloid deposition in leptomeningeal vessels and diffuse amyloid plaques (inset) (C). Immunohistochemical staining for CD5 showed that leptomeningeal inflammation was mainly composed of T lymphocytes (D). Original magnification×400.
