Article Figures & Data
- Figure 1
Flow chart describing the patient inclusion criteria. SACE, stent-assisted coil embolisation.
- Figure 2
Daily antiplatelet use since stent-assisted coil embolisation.
- Figure 3
Cumulative incidence of cerebral infarction (A), and major haemorrhage (B) according to APT. Simon and Makuch plot showed no difference in the risk of cerebral infarction according to APT (Mantel-Byar test, p=0.999, A). APT increased the risk of major haemorrhage (Mantel-Byar test, p<0.001, B). APT, antiplatelet therapy; SACE, stent assisted coil embolisation.
- Figure 4
Plot of estimated time-varying HRs of APT for cerebral infarction (A), and major haemorrhage (B) after SACE for unruptured cerebral aneurysm. Plots show simulated time-varying multivariable HRs of APT as a red solid line and the CIs of central 50% (dark red) and 95% (light red) as shaded areas. APT, antiplatelet therapy; SACE, stent-assisted coil embolisation.
- Table 1
Impact of antiplatelet therapy on primary outcomes
Cerebral infarction (n=379) Major haemorrhage (n=190) No at risk Event no aHR (95% CI) P value No at risk Event no aHR (95% CI) P value 1–12 months 17 692 141 0.56 (0.35 to 0.89) 0.014 17 692 68 3.69 (0.89 to 15.36) 0.072 12–24 months 15 679 97 0.73 (0.48 to 1.12) 0.144 15 750 39 1.23 (0.60 to 2.52) 0.568 >24 months 12 333 141 1.01 (0.72 to 1.43) 0.933 12 453 83 1.76 (1.11 to 2.87) 0.016 Data were obtained from multivariable time-dependent Cox proportional hazards regression model for the development of outcome. The reference is the absence of APT during this period. Adjustments were made for age, sex, insurance status, hypertension, diabetes, congestive heart failure, chronic renal disease, hepatic disease, chronic obstructive lung disease, and cancer, and use of statin.
aHR, adjusted HR; APT, antiplatelet therapy.
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