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CCL17 exerts neuroprotection through activation of CCR4/mTORC2 axis in microglia after subarachnoid haemorrhage in rats

Anke Zhang, Yibo Liu, Houshi Xu, Zeyu Zhang, Xiaoyu Wang, Ling Yuan, Cameron Lenahan, Chuan Zhang, Junkun Jiang, Chaoyou Fang, Yuanjian Fang, Jianmin Zhang, Sheng Chen
DOI: 10.1136/svn-2022-001659 Published 24 February 2023
Anke Zhang
1 Department of Neurosurgery, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China
2 Clinical Research Center for Neurological Diseases of Zhejiang Province, Hangzhou, Zhejiang, China
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Yibo Liu
1 Department of Neurosurgery, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China
2 Clinical Research Center for Neurological Diseases of Zhejiang Province, Hangzhou, Zhejiang, China
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Houshi Xu
3 Department of Neurosurgery, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Zeyu Zhang
1 Department of Neurosurgery, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China
2 Clinical Research Center for Neurological Diseases of Zhejiang Province, Hangzhou, Zhejiang, China
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Xiaoyu Wang
1 Department of Neurosurgery, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China
2 Clinical Research Center for Neurological Diseases of Zhejiang Province, Hangzhou, Zhejiang, China
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Ling Yuan
3 Department of Neurosurgery, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Cameron Lenahan
4 Department of Biomedical Sciences, Burrell College of Osteopathic Medicine, Las Cruces, New Mexico, USA
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Chuan Zhang
5 Department of Biology, Tongji University, Shanghai, China
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Junkun Jiang
5 Department of Biology, Tongji University, Shanghai, China
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Chaoyou Fang
3 Department of Neurosurgery, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Yuanjian Fang
1 Department of Neurosurgery, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China
2 Clinical Research Center for Neurological Diseases of Zhejiang Province, Hangzhou, Zhejiang, China
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Jianmin Zhang
1 Department of Neurosurgery, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China
2 Clinical Research Center for Neurological Diseases of Zhejiang Province, Hangzhou, Zhejiang, China
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Sheng Chen
1 Department of Neurosurgery, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China
2 Clinical Research Center for Neurological Diseases of Zhejiang Province, Hangzhou, Zhejiang, China
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Article Information

vol. 8 no. 1 4-16
DOI 
https://doi.org/10.1136/svn-2022-001659
PubMed 
35882433

Print ISSN 
2059-8688
Online ISSN 
2059-8696
History 
  • Received April 21, 2022
  • Accepted June 13, 2022
  • Published online February 24, 2023.

Article Versions

  • Previous version (July 26, 2022 - 06:43).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

Author Information

  1. Anke Zhang1,2,
  2. Yibo Liu1,2,
  3. Houshi Xu3,
  4. Zeyu Zhang1,2,
  5. Xiaoyu Wang1,2,
  6. Ling Yuan3,
  7. Cameron Lenahan4,
  8. Chuan Zhang5,
  9. Junkun Jiang5,
  10. Chaoyou Fang3,
  11. Yuanjian Fang1,2,
  12. Jianmin Zhang1,2,
  13. Sheng Chen1,2
  1. 1 Department of Neurosurgery, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China
  2. 2 Clinical Research Center for Neurological Diseases of Zhejiang Province, Hangzhou, Zhejiang, China
  3. 3 Department of Neurosurgery, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
  4. 4 Department of Biomedical Sciences, Burrell College of Osteopathic Medicine, Las Cruces, New Mexico, USA
  5. 5 Department of Biology, Tongji University, Shanghai, China
  1. Correspondence to Dr Sheng Chen; saintchan{at}zju.edu.cn; Dr Jianmin Zhang; zjm135{at}zju.edu.cn; Dr Yuanjian Fang; sandman0506{at}zju.edu.cn
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Vol 8 Issue 1 Table of Contents
Stroke and Vascular Neurology: 8 (1)
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CCL17 exerts neuroprotection through activation of CCR4/mTORC2 axis in microglia after subarachnoid haemorrhage in rats
Anke Zhang, Yibo Liu, Houshi Xu, Zeyu Zhang, Xiaoyu Wang, Ling Yuan, Cameron Lenahan, Chuan Zhang, Junkun Jiang, Chaoyou Fang, Yuanjian Fang, Jianmin Zhang, Sheng Chen
Stroke and Vascular Neurology Feb 2023, 8 (1) 4-16; DOI: 10.1136/svn-2022-001659

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CCL17 exerts neuroprotection through activation of CCR4/mTORC2 axis in microglia after subarachnoid haemorrhage in rats
Anke Zhang, Yibo Liu, Houshi Xu, Zeyu Zhang, Xiaoyu Wang, Ling Yuan, Cameron Lenahan, Chuan Zhang, Junkun Jiang, Chaoyou Fang, Yuanjian Fang, Jianmin Zhang, Sheng Chen
Stroke and Vascular Neurology Feb 2023, 8 (1) 4-16; DOI: 10.1136/svn-2022-001659
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CCL17 exerts neuroprotection through activation of CCR4/mTORC2 axis in microglia after subarachnoid haemorrhage in rats
Anke Zhang, Yibo Liu, Houshi Xu, Zeyu Zhang, Xiaoyu Wang, Ling Yuan, Cameron Lenahan, Chuan Zhang, Junkun Jiang, Chaoyou Fang, Yuanjian Fang, Jianmin Zhang, Sheng Chen
Stroke and Vascular Neurology Feb 2023, 8 (1) 4-16; DOI: 10.1136/svn-2022-001659
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