Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase II randomised placebo-controlled double-blind multicentre trial

Nawaf Yassi; Henry Zhao; Leonid Churilov; Bruce C V Campbell; Teddy Wu; Henry Ma; Andrew Cheung; Timothy Kleinig; Helen Brown; Philip Choi; Jiann-Shing Jeng; Annemarei Ranta; Hao-Kuang Wang; Geoffrey C Cloud; Rohan Grimley; Darshan Shah; Neil Spratt; Der-Yang Cho; Karim Mahawish; Lauren Sanders; John Worthington; Ben Clissold; Atte Meretoja; Vignan Yogendrakumar; Mai Duy Ton; Duc Phuc Dang; Nguyen Thai My Phuong; Huy-Thang Nguyen; Chung Y Hsu; Gagan Sharma; Peter J Mitchell; Bernard Yan; Mark W Parsons; Christopher Levi; Geoffrey A Donnan; Stephen M Davis

doi:10.1136/svn-2021-001070

Open Access

Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase II randomised placebo-controlled double-blind multicentre trial

Nawaf Yassi, Henry Zhao, Leonid Churilov, Bruce C V Campbell, Teddy Wu, Henry Ma, Andrew Cheung, Timothy Kleinig, Helen Brown, Philip Choi, Jiann-Shing Jeng, Annemarei Ranta, Hao-Kuang Wang, Geoffrey C Cloud, Rohan Grimley, Darshan Shah, Neil Spratt, Der-Yang Cho, Karim Mahawish, Lauren Sanders, John Worthington, Ben Clissold, Atte Meretoja, Vignan Yogendrakumar, Mai Duy Ton, Duc Phuc Dang, Nguyen Thai My Phuong, Huy-Thang Nguyen, Chung Y Hsu, Gagan Sharma, Peter J Mitchell, Bernard Yan, Mark W Parsons, Christopher Levi, Geoffrey A Donnan, Stephen M Davis

DOI: 10.1136/svn-2021-001070 Published 27 April 2022

Nawaf Yassi

1 Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia

2 Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Nawaf Yassi

Henry Zhao

1 Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia

3 Ambulance Victoria, Melbourne, Victoria, Australia

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Henry Zhao

Leonid Churilov

1 Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia

4 Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Leonid Churilov

Bruce C V Campbell

1 Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia

5 Stroke Division, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Bruce C V Campbell

Teddy Wu

6 Department of Neurology, Christchurch Hospital, Christchurch, New Zealand

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Teddy Wu

Henry Ma

7 Department of Neurology, Monash Medical Centre, Monash University, Clayton, Victoria, Australia

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Henry Ma

Andrew Cheung

8 Department of Interventional Neuroradiology, Liverpool Hospital, Liverpool, New South Wales, Australia

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Andrew Cheung

Timothy Kleinig

9 Department of Neurology, Royal Adelaide Hospital, Adelaide, South Australia, Australia

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Timothy Kleinig

Helen Brown

10 Department of Neurology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Philip Choi

11 Department of Neurology, Box Hill Hospital, Eastern Health, Box Hill, Victoria, Australia

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Philip Choi

Jiann-Shing Jeng

12 Stroke Centre and Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jiann-Shing Jeng

Annemarei Ranta

13 Department of Medicine, Dunedin School of Medicine, University of Otago, Wellington, New Zealand

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Annemarei Ranta

Hao-Kuang Wang

14 Department of Neurosurgery, E-Da Hospital, Yanchao, Kaohsiung, Taiwan

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Hao-Kuang Wang

Geoffrey C Cloud

15 Department of Neurology, Alfred Hospital, Melbourne, Victoria, Australia

16 Department of Clinical Neuroscience, Monash University Central Clinical School, Melbourne, Victoria, Australia

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Geoffrey C Cloud

Rohan Grimley

17 Department of Medicine, Sunshine Coast University Hospital, Nambour, Queensland, Australia

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Rohan Grimley

Darshan Shah

18 Department of Neurology, Gold Coast University Hospital, Southport, Queensland, Australia

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Darshan Shah

Neil Spratt

19 Department of Neurology, John Hunter Hospital, The University of Newcastle, Newcastle, New South Wales, Australia

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Neil Spratt

Der-Yang Cho

20 Department of Neurosurgery, China Medical University Hospital, Taichung, Taiwan

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Der-Yang Cho

Karim Mahawish

21 Department of Internal Medicine, Palmerston North Hospital, Palmerston North, New Zealand

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Lauren Sanders

22 Department of Neurology, St Vincent's Hospital, Fitzroy, Victoria, Australia

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Lauren Sanders

John Worthington

23 Department of Neurology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ben Clissold

24 Department of Neurology, Geelong Hospital, Geelong, Victoria, Australia

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Ben Clissold

Atte Meretoja

25 Department of Neurology, Helsinki University Hospital, Helsinki, Finland

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Atte Meretoja

Vignan Yogendrakumar

1 Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Vignan Yogendrakumar

Mai Duy Ton

26 Stroke Center, Bach Mai Hospital, Hanoi, Viet Nam

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Mai Duy Ton

Duc Phuc Dang

27 Stroke Department, 103 Military Hospital, Hanoi, Hanoi, Viet Nam

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Duc Phuc Dang

Nguyen Thai My Phuong

28 Department of Neurology, Nguyen Tri Phuong Hospital, Ho Chi Minh City, Viet Nam

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Huy-Thang Nguyen

29 Department of Cerebrovascular Disease, 115 Hospital, Ho Chi Minh City, Viet Nam

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Chung Y Hsu

30 Department of Neurology, China Medical University, Taichung, Taiwan

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Chung Y Hsu

Gagan Sharma

1 Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Peter J Mitchell

31 Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Bernard Yan

1 Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Bernard Yan

Mark W Parsons

1 Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia

32 Department of Neurology, Liverpool Hospital, Ingham Institute for Applied Medical Research, University of New South Wales South Western Sydney Clinical School, Sydney, New South Wales, Australia

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Mark W Parsons

Christopher Levi

19 Department of Neurology, John Hunter Hospital, The University of Newcastle, Newcastle, New South Wales, Australia

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Christopher Levi

Geoffrey A Donnan

1 Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Geoffrey A Donnan

Stephen M Davis

1 Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Stephen M Davis

Article
Figures & Data
eLetters
Info & Metrics
PDF

Article Figures & Data

Figures

Download figure
Open in new tab
Download powerpoint
Figure 1
Haematoma growth occurring between baseline (A, C) CT and follow-up CT (B, D) in a patient with a right basal ganglia haemorrhage. Panel C and D reflect the region of interest planimetric analysis used to measure haematoma volume (intraventricular segment measured separately).
Download figure
Open in new tab
Download powerpoint
Figure 2
Key trial timepoints and activities. ICH, intracerebral haemorrhage; mRS, Modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; TXA, tranexamic acid.

PreviousNext

Vol 7 Issue 2 Table of Contents

Table of Contents
Table of Contents (PDF)
About the Cover
Index by author
Front Matter (PDF)

Thank you for your interest in spreading the word on Stroke and Vascular Neurology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase II randomised placebo-controlled double-blind multicentre trial

Message Subject (Your Name) has sent you a message from Stroke and Vascular Neurology

Message Body (Your Name) thought you would like to see the Stroke and Vascular Neurology web site.

Your Personal Message

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Alerts

User Name *

Password *

Email *

Citation Tools

Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase II randomised placebo-controlled double-blind multicentre trial

Stroke and Vascular Neurology Apr 2022, 7 (2) 158-165; DOI: 10.1136/svn-2021-001070

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

Cite This

APA
Chicago
Endnote
MLA

Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase II randomised placebo-controlled double-blind multicentre trial

Stroke and Vascular Neurology Apr 2022, 7 (2) 158-165; DOI: 10.1136/svn-2021-001070

Download PDF

Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase II randomised placebo-controlled double-blind multicentre trial