Open Access
Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase II randomised placebo-controlled double-blind multicentre trial
Nawaf Yassi, Henry Zhao, Leonid Churilov, Bruce C V Campbell, Teddy Wu, Henry Ma, Andrew Cheung, Timothy Kleinig, Helen Brown, Philip Choi, Jiann-Shing Jeng, Annemarei Ranta, Hao-Kuang Wang, Geoffrey C Cloud, Rohan Grimley, Darshan Shah, Neil Spratt, Der-Yang Cho, Karim Mahawish, Lauren Sanders, John Worthington, Ben Clissold, Atte Meretoja, Vignan Yogendrakumar, Mai Duy Ton, Duc Phuc Dang, Nguyen Thai My Phuong, Huy-Thang Nguyen, Chung Y Hsu, Gagan Sharma, Peter J Mitchell, Bernard Yan, Mark W Parsons, Christopher Levi, Geoffrey A Donnan, Stephen M Davis
DOI: 10.1136/svn-2021-001070 Published 27 April 2022
Nawaf Yassi
1
Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
2
Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Henry Zhao
1
Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
3
Ambulance Victoria, Melbourne, Victoria, Australia
Leonid Churilov
1
Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
4
Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia
Bruce C V Campbell
1
Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
5
Stroke Division, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia
Teddy Wu
6
Department of Neurology, Christchurch Hospital, Christchurch, New Zealand
Henry Ma
7
Department of Neurology, Monash Medical Centre, Monash University, Clayton, Victoria, Australia
Andrew Cheung
8
Department of Interventional Neuroradiology, Liverpool Hospital, Liverpool, New South Wales, Australia
Timothy Kleinig
9
Department of Neurology, Royal Adelaide Hospital, Adelaide, South Australia, Australia
Helen Brown
10
Department of Neurology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
Philip Choi
11
Department of Neurology, Box Hill Hospital, Eastern Health, Box Hill, Victoria, Australia
Jiann-Shing Jeng
12
Stroke Centre and Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan
Annemarei Ranta
13
Department of Medicine, Dunedin School of Medicine, University of Otago, Wellington, New Zealand
Hao-Kuang Wang
14
Department of Neurosurgery, E-Da Hospital, Yanchao, Kaohsiung, Taiwan
Geoffrey C Cloud
15
Department of Neurology, Alfred Hospital, Melbourne, Victoria, Australia
16
Department of Clinical Neuroscience, Monash University Central Clinical School, Melbourne, Victoria, Australia
Rohan Grimley
17
Department of Medicine, Sunshine Coast University Hospital, Nambour, Queensland, Australia
Darshan Shah
18
Department of Neurology, Gold Coast University Hospital, Southport, Queensland, Australia
Neil Spratt
19
Department of Neurology, John Hunter Hospital, The University of Newcastle, Newcastle, New South Wales, Australia
Der-Yang Cho
20
Department of Neurosurgery, China Medical University Hospital, Taichung, Taiwan
Karim Mahawish
21
Department of Internal Medicine, Palmerston North Hospital, Palmerston North, New Zealand
Lauren Sanders
22
Department of Neurology, St Vincent's Hospital, Fitzroy, Victoria, Australia
John Worthington
23
Department of Neurology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
Ben Clissold
24
Department of Neurology, Geelong Hospital, Geelong, Victoria, Australia
Atte Meretoja
25
Department of Neurology, Helsinki University Hospital, Helsinki, Finland
Vignan Yogendrakumar
1
Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
Mai Duy Ton
26
Stroke Center, Bach Mai Hospital, Hanoi, Viet Nam
Duc Phuc Dang
27
Stroke Department, 103 Military Hospital, Hanoi, Hanoi, Viet Nam
Nguyen Thai My Phuong
28
Department of Neurology, Nguyen Tri Phuong Hospital, Ho Chi Minh City, Viet Nam
Huy-Thang Nguyen
29
Department of Cerebrovascular Disease, 115 Hospital, Ho Chi Minh City, Viet Nam
Chung Y Hsu
30
Department of Neurology, China Medical University, Taichung, Taiwan
Gagan Sharma
1
Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
Peter J Mitchell
31
Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia
Bernard Yan
1
Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
Mark W Parsons
1
Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
32
Department of Neurology, Liverpool Hospital, Ingham Institute for Applied Medical Research, University of New South Wales South Western Sydney Clinical School, Sydney, New South Wales, Australia
Christopher Levi
19
Department of Neurology, John Hunter Hospital, The University of Newcastle, Newcastle, New South Wales, Australia
Geoffrey A Donnan
1
Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
Stephen M Davis
1
Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia

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Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase II randomised placebo-controlled double-blind multicentre trial
Nawaf Yassi, Henry Zhao, Leonid Churilov, Bruce C V Campbell, Teddy Wu, Henry Ma, Andrew Cheung, Timothy Kleinig, Helen Brown, Philip Choi, Jiann-Shing Jeng, Annemarei Ranta, Hao-Kuang Wang, Geoffrey C Cloud, Rohan Grimley, Darshan Shah, Neil Spratt, Der-Yang Cho, Karim Mahawish, Lauren Sanders, John Worthington, Ben Clissold, Atte Meretoja, Vignan Yogendrakumar, Mai Duy Ton, Duc Phuc Dang, Nguyen Thai My Phuong, Huy-Thang Nguyen, Chung Y Hsu, Gagan Sharma, Peter J Mitchell, Bernard Yan, Mark W Parsons, Christopher Levi, Geoffrey A Donnan, Stephen M Davis
Stroke and Vascular Neurology Apr 2022, 7 (2) 158-165; DOI: 10.1136/svn-2021-001070

Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase II randomised placebo-controlled double-blind multicentre trial
Nawaf Yassi, Henry Zhao, Leonid Churilov, Bruce C V Campbell, Teddy Wu, Henry Ma, Andrew Cheung, Timothy Kleinig, Helen Brown, Philip Choi, Jiann-Shing Jeng, Annemarei Ranta, Hao-Kuang Wang, Geoffrey C Cloud, Rohan Grimley, Darshan Shah, Neil Spratt, Der-Yang Cho, Karim Mahawish, Lauren Sanders, John Worthington, Ben Clissold, Atte Meretoja, Vignan Yogendrakumar, Mai Duy Ton, Duc Phuc Dang, Nguyen Thai My Phuong, Huy-Thang Nguyen, Chung Y Hsu, Gagan Sharma, Peter J Mitchell, Bernard Yan, Mark W Parsons, Christopher Levi, Geoffrey A Donnan, Stephen M Davis
Stroke and Vascular Neurology Apr 2022, 7 (2) 158-165; DOI: 10.1136/svn-2021-001070
Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase II randomised placebo-controlled double-blind multicentre trial
Nawaf Yassi, Henry Zhao, Leonid Churilov, Bruce C V Campbell, Teddy Wu, Henry Ma, Andrew Cheung, Timothy Kleinig, Helen Brown, Philip Choi, Jiann-Shing Jeng, Annemarei Ranta, Hao-Kuang Wang, Geoffrey C Cloud, Rohan Grimley, Darshan Shah, Neil Spratt, Der-Yang Cho, Karim Mahawish, Lauren Sanders, John Worthington, Ben Clissold, Atte Meretoja, Vignan Yogendrakumar, Mai Duy Ton, Duc Phuc Dang, Nguyen Thai My Phuong, Huy-Thang Nguyen, Chung Y Hsu, Gagan Sharma, Peter J Mitchell, Bernard Yan, Mark W Parsons, Christopher Levi, Geoffrey A Donnan, Stephen M Davis
Stroke and Vascular Neurology Apr 2022, 7 (2) 158-165; DOI: 10.1136/svn-2021-001070