Article Figures & Data
- Figure 1
Distribution of modified Rankin Scale (mRS) score.
- Table 1
Baseline characteristics
Variable r-tPA (N=2666) UK (N=1144) P value Dose, mg/U per kg 0.88 (0.78–0.90) 1.71 (1.43–2.00)×104 – Age, years 63.8 (11.5) 63.5 (63.8) 0.399 Male 1827 (68.5) 779 (68.1) 0.791 BMI, kg/m2 24.1 (3.8) 24.2 (3.4) 0.490 Educational level 0.006 Primary school degree or below 762 (28.6) 370 (32.3) Middle school degree 1623 (60.9) 685 (59.5) Bachelor degree or above 281 (10.5) 89 (7.8) Current smoker 1006 (37.7) 442 (38.6) 0.599 Current drinker 607 (22.8) 279 (24.4) 0.278 Hypertension 1435/2599 (55.2) 599/1097 (54.6) 0.733 Coronary heart disease 394/2549 (15.5) 167/1069 (15.6) 0.900 History of stroke 532/2573 (20.7) 263/1089 (22.6) 0.020 Diabetes mellitus 507/2600 (19.5) 209/1092 (19.1) 0.800 Atrial fibrillation 254/2547 (10.0) 93/1064 (8.7) 0.252 SBP, mm Hg 151.2 (22.8) 153.3 (23.7) 0.009 OTT, min 170 (128–210) 190 (142–234) <0.001 DNT, min 30 (14–55) 35 (18–61) <0.001 NIHSS score 6.0 (3.0–10.0) 5.0 (3.0–9.0) 0.010 TOAST classification 0.639 LAA 1297 (49.4) 538 (47.7) CE 304 (11.6) 124 (11.0) SAO 814 (31.0) 378 (33.5) ODC 63 (2.4) 24 (2.1) UND 149 (5.7) 65 (5.8) Hospital classification 0.417 Tertiary 2418 (90.7) 1047 (91.5) Secondary 248 (9.3) 97 (8.5) Data are n/N (%), mean (SD) or median (IQR).
BMI, body mass index; CE, cardioembolism; DNT, door-to-needle time; LAA, large-artery atherosclerosis; NIHSS, National Institutes of Health Stroke Scale; ODC, stroke of other determined cause; OTT, onset-to-treatment time; r-tPA, recombinant tissue plasminogen activator; SAO, small-artery occlusion; SBP, systolic blood pressure; TOAST, Trial of Org 10172 in Acute Stroke Treatment; UK, urokinase; UND, stroke of undetermined cause.
- Table 2
Effectiveness and safety outcomes for rt-PA and UK
Outcome rt-PA n/N (%) UK n/N (%) Unadjusted OR or mean difference (95% CI) P value Adjusted OR or mean difference (95% CI)* P value mRS scores 0 to 1 at 90 days 1902/2666 (71.3) 795/1144 (69.5) 1.09 (0.94 to 1.27) 0.250 1.15 (0.98 to 1.35) 0.078 mRS scores 0 to 2 at 90 days 2174/2666 (81.5) 910/1144 (79.5) 1.14 (0.96 to 1.35) 0.150 1.22 (1.01 to 1.46) 0.036 mRS distribution at 90 days 0.369 0.140 0 1043/2666 (39.1) 409/1144 (35.8) 1 859/2666 (32.2) 386/1144 (33.7) 2 272/2666 (10.2) 115/1144 (10.1) 3 175/2666 (6.6) 94/1144 (8.2) 4 118/2666 (4.4) 50/1144 (4.4) 5 77/2666 (2.9) 32/1144 (2.8) 6 122/2666 (4.6) 58/1144 (5.1) ΔNIHSS score to 24 hours† 2.4±5.1 2.0±4.4 0.20 (−0.21 to 0.61) 0.334 0.23 (−0.10 to 0.57) 0.173 ΔNIHSS score to 14 days† 3.7±6.1 3.1±5.5 0.14 (−0.25 to 0.53) 0.470 0.28 (−0.14 to 0.70) 0.194 sICH at 36 hours 30/2666 (1.1) 16/1144 (1.4) 0.80 (0.44 to 1.48) 0.479 0.69 (0.35 to 1.35) 0.281 Other bleeding events 30/2666 (1.1) 8/1144 (0.7) 1.62 (0.74 to 3.54) 0.230 1.48 (0.66 to 3.29) 0.341 Recurrent stroke at 90 days 36/2557 (1.4) 28/1097 (2.6) 0.55 (0.33 to 0.90) 0.016 0.57 (0.34 to 0.94) 0.028 All-cause mortality at 90 days 122/2666 (4.6) 58/1144 (5.1) 0.90 (0.65 to 1.24) 0.510 0.76 (0.52 to 1.12) 0.164 *Propensity scores adjustment for all baseline variables in the model.
†From baseline.
mRS, modified Rankin scale; NIHSS, National Institutes of Health Stroke Scale; rt-PA, recombinant tissue plasminogen activator; sICH, symptomatic intracerebral haemorrhage; UK, urokinase.
- Table 3
Sensitivity analysis for different methods of adjustment
Outcome Adjusted OR or mean difference (95% CI)* P value Adjusted OR or mean difference (95% CI)† P value mRS scores 0 to 1 at 90 days 1.19 (1.00 to 1.42) 0.047 1.15 (0.98 to 1.35) 0.078 mRS scores 0 to 2 at 90 days 1.27 (1.04 to 1.56) 0.021 1.22 (1.01 to 1.46) 0.036 mRS distribution at 90 days 0.060 0.140 ΔNIHSS score to 24 hours‡ 0.24 (−0.07 to 0.55) 0.125 0.23 (−0.10 to 0.57) 0.173 ΔNIHSS score to 14 days‡ 0.28 (−0.09 to 0.65) 0.133 0.28 (−0.14 to 0.70) 0.194 sICH at 36 hours 0.72 (0.36 to 1.43) 0.349 0.69 (0.35 to 1.35) 0.281 Other bleeding events 1.43 (0.64 to 3.19) 0.384 1.48 (0.66 to 3.29) 0.341 Recurrent stroke at 90 days 0.57 (0.34 to 0.95) 0.030 0.57 (0.34 to 0.94) 0.028 All-cause mortality at 90 days 0.74 (0.49 to 1.11) 0.148 0.76 (0.52 to 1.12) 0.164 *Adjustment with all baseline variables in the model.
†Propensity scores used to adjust all baseline variables in the model.
‡From baseline.
mRS, modified Rankin scale; NIHSS, National Institutes of Health Stroke Scale; rt-PA, recombinant tissue plasminogen activator; sICH, symptomatic intracerebral haemorrhage; UK, urokinase.
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