Article Figures & Data
- Figure 1
ROC curves for the association between baseline and delayed ICH score for 30-day (A), 90-day (B) and 180-day mortality (C). ICH, intracerebral haemorrhage; ROC, receiver operating characteristic.
- Figure 2
ROC curves for the association between baseline and delayed ICH score for 30-day (A), 90-day (B) and 180-day poor functional outcome (C). ICH, intracerebral haemorrhage; ROC, receiver operating characteristic.
- Table 1
Components of the original ICH score, modified-ICH score, max-ICH score and FUNC score and their respective weightings
ICH score Modified-ICH score Max-ICH score FUNC score Variables (maximum points possible) GCS (2) GCS (2) NIHSS (3) GCS (2) ICH volume (1) ICH volume (2) ICH volume (2) ICH volume (4) Intraventricular haemorrhage (1) Intraventricular haemorrhage (1) Intraventricular haemorrhage (1) Cognitive impairment (1) Location (ie, infratentorial) (1) Oral anticoagulation (1) Location (2) Age (1) Age (3) Age (2) Total points possible 6 5 10 11 GCS, Glasgow Coma Scale; ICH, intracerebral haemorrhage; NIHSS, National Institutes of Health Stroke Severity Scale.
- Table 2
Baseline characteristics of those who were included/excluded from analysis for ICH score, FUNC score and modified-ICH score
Characteristics Included (n=277) Excluded (n=16) P value Age, years (mean±SD) 60.0±11.8 65.3±13.9 0.086 Male sex (n, %) 169 (61.0) 12 (75.0) 0.30 Medical history (n, %) Hypertension 227 (81.9) 12 (75.0) 0.51 Dementia 5 (1.8) 0 1.00 Diabetes mellitus 74 (26.7) 1 (6.25) 0.08 Previous stroke 26 (9.4) 0 0.34 Previous ICH 10 (3.6) 0 1.00 Clinical information (mean±SD) Treated with DFO 139 (50.2%) 6 (37.5%) 0.442 Systolic blood pressure (mm Hg) 136.0±15.6 134.6±16.0 0.74 Diastolic blood pressure (mm Hg) 70.8±13.6 72.9±11.8 0.57 Baseline GCS 13.2±2.2 12.3±2.2 0.12 Delayed GCS 13.6±2.3 10.5±2.5 <0.001 Radiographic information Baseline ICH vol (mL, mean±SD) 18.3±1.0 49.3±8.4 <0.001 Delayed ICH vol (mL, mean±SD) 17.9±1.0 17.3±9.8 0.95 Baseline IVH presence (n, %) 116 (41.9) 4 (25.0) 0.20 Delayed IVH presence (n, %) 119 (43.0) 1 (6.3) 0.003 Bolded text signifies statistical significance at the level of p < 0.05
DFO, deferoxamine mesylate; GCS, Glasgow Coma Scale; ICH, intracerebral haemorrhage; IVH, intraventricular haemorrhage.
- Table 3
Area under the curve values for ROC curves of baseline versus delayed prognostication scores (listed left) for 30-day, 90-day and 180-day mortality, and poor functional outcome (modified Rankin Scale of 4–5) in all patients (placebo treated and DFO treated) meeting inclusion criteria
Mortality (baseline vs delayed) Poor functional outcome (baseline vs delayed) 30-day 90-day 180-day 30-day 90-day 180-day Original ICH score 0.73 vs 0.82 (0.002) 0.74 vs 0.82 (0.015) 0.74 vs 0.83 (0.005) 0.71 vs 0.74 (0.14) 0.74 vs 0.72 (0.34) 0.79 vs 0.77 (0.34) Modified-ICH score 0.76 vs 0.83 (0.027) 0.76 vs 0.82 (0.080) 0.73 vs 0.80 (0.036) 0.71 vs 0.75 (0.033) 0.73 vs 0.73 (0.86) 0.77 vs 0.76 (0.78) Max-ICH score 0.74 vs 0.83 (<0.000) 0.74 vs 0.83 (<0.000) 0.77 vs 0.84 (0.008) 0.77 vs 0.82 (0.011) 0.84 vs 0.82 (0.373) 0.86 vs 0.82 (0.13) FUNC score 0.66 vs 0.75 (0.054) 0.66 vs 0.74 (0.058) 0.70 vs 0.77 (0.061) 0.63 vs 0.62 (0.39) 0.69 vs 0.65 (0.18) 0.68 vs 0.66 (0.43) Statistical significance is highlighted using bold font. P values are represented in parentheses.
DFO, deferoxamine mesylate; ICH, intracerebral haemorrhage; ROC, receiver operating characteristic.
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