Article Figures & Data
Figures
- Figure 1
P-selectin surface expression in response to arachidonic acid. MF, median fluorescence.
- Figure 2
P-selectin surface expression in response to ADP. MF, median fluorescence.
Tables
- Table 1
Baseline characteristics of participants
All Clopidogrel only Aspirin+clopidogrel P value n (%) 62 (100.0) 59 (95.2) 3 (4.8) Male (%) 33 (53.2) 33 (55.9) 0 0.058 Age, years 63.7 (13.7) 63.0 (13.5) 78.0 (8.9) 0.06 Preindex event Stroke (%) 9 (14.5) 8 (13.6) 1 (33.3) 0.34 TIA (%) 8 (12.9) 6 (10.2) 2 (66.7) 0.004 IHD (%) 6 (9.7) 5 (8.5) 1 (33.3) 0.16 Diabetes (%) 11 (17.7) 10 (16.9) 1 (33.3) 0.47 Smoking (%) 9 (14.5) 9 (15.3) 0 0.74 Index event Ischaemic stroke (%) 44 (71.0) 42 (71.2) 2 (66.7) 0.87 TIA (%) 18 (29.0) 17 (28.8) 1 (33.3) 0.87 Thrombolysis (%) 4 (6.5) 4 (6.8) 0 0.64 Length of stay, days 1 [1,3] (0–60) 1 [0,3] (0–60) 2 [−] (1-7) 0.25 At recruitment Time from index event, days 49 [35,75] (1–285) 52 [36,76] (1–285) 1 [−] (1–22) 0.006 mRS 0 [0,1] 0 [0,1] 0 [−] 0.89 On clopidogrel (%) 62 (100) 59 (100) 3 (100) – Time on clopidogrel, days 50 [35, 76] (8–1878) 48 [35, 69] (8–1878) 313 [−] (8–962) 0.41 On aspirin (%) 3 (4.8) 0 3 (100) – Treated hypertension (%) 43 (69.4) 40 (67.8) 3 (100) 0.24 Treated hypercholesterolaemia (%) 59 (95.2) 56 (94.9) 3 (100) 0.69 Proton pump inhibitor (%) 19 (30.6) 17 (28.8) 2 (66.7) 0.17 Systolic BP, mm Hg 135.7 (19.5) 134.9 (19.3) 150.0 (22.5) 0.21 Diastolic BP, mm Hg 76.3 (13.5) 76.6 (13.7) 71.7 (7.8) 0.26 Bleeding history on antiplatelet(s) Minor bleeding (%) 17 (27.4) 17 (28.8) 0 0.28 Major bleeding (%) 0 0 0 – Data are number (%), mean (SD), median [IQR], (min–max); comparison between clopidogrel versus aspirin+clopidogrel groups by χ2 test, Kruskal-Wallis test or one-way analysis of variance.
Sixty-three participants recruited but 1 had no data collected.
BP, blood pressure; IHD, ischaemic heart disease; mRS, modified Rankin Scale; TIA, transient ischaemic attack.
- Table 2
P-selectin in response to arachidonic acid (AA, aspirin test) and ADP (clopidogrel test)
All Clopidogrel only Aspirin +clopidogrel P value AA MF Number (%) 62 (100) 59 (95.2) 3 (4.8) – Mean (SD) 590 (330) 612 (323) 160 (118) 0.020 Median [IQR] 528 [317, 834] 547 [375,851] 103 [−] 0.013 >500 (%) 34 (54.8) 34 (57.6) 0 0.050 ADP MF Number (%) 62 (100) 59 (95.2) 3 (4.8) – Mean (SD) 493 (266) 498 (269) 392 (202) 0.51 Median [IQR] 429 [303, 656] 425 [307, 656] 502 [−] 0.54 >860 (%) 7 (11.3) 7 (11.9) 0 0.53 Data are number (%), median [IQR] or mean (SD); comparisons by χ2 test, Kruskal-Wallis test or one-way analysis of variance.
MF, median fluorescence.
- Table 3
P-selectin in response to arachidonic acid (AA, aspirin test) and ADP (clopidogrel test) by minor or no bleeding
All Minor bleeding No bleeding P value AA MF Number (%) 62 (100) 17 (27.4) 45 (72.6) – Mean (SD) 590 (330) 644 (280) 569 (348) 0.43 Median [IQR] 528 [317, 834] 691 [438, 791] 495 [296, 870] 0.28 >500 (%) 34 (54.8) 12 (70.6) 22 (48.9) 0.13 ADP MF Number (%) 62 (100) 17 (27.4) 45 (72.6) – Mean (SD) 493 (266) 481 (213) 498 (286) 0.83 Median [IQR] 429 [303, 656] 444 [321, 685] 425 [285, 656] 0.88 >860 (%) 7 (11.3) 0 7 (15.6) 0.08 Data are number (%), median [IQR] or mean (SD); comparisons by χ2 test, Kruskal-Wallis test or one-way analysis of variance.
MF, median fluorescence.
- Table 4
Correlations between baseline P-selectin clopidogrel test and clinical outcomes after day 90
r P value Number (%) 19 (30.2) – mRS 0.164 0.50 Barthel index −0.208 0.39 EQ-VAS 0.075 0.76 t-MMSE −0.060 0.81 TICS-M −0.231 0.34 Verbal fluency −0.235 0.33 Zung −0.125 0.61 Data are number (%), r with two-sided p values using Spearman correlation.
EQ-VAS, European Quality of Life Visual Analogue Scale; mRS, modified Rankin Scale; TICS-M, Modified Telephone Interview for Cognition Scale; t-MMSE, telephone Mini-Mental State Examination.
