Article Figures & Data
Figures
- Figure 1
Interaction tree generated by supervised cluster analysis. This picture illustrates the process of interaction tree model. Group C was first split out, which showed the heterogeneity between group C and the rest in aspects of tPA effects on sICH. Then group A and group B were separated. NIHSS, National Institutes of Health Stroke Scale; sICH, symptomatic intracranial haemorrhage; tPA, tissue plasminogen activator.
Tables
- Table 1
Rare event logistic regression of interventional effect on efficacy and safety among groups
n (%) n1 (%) n2 (%) OR 95% CI P value Interventional effect on clinical improvement Mild stroke 283 (32.7) 65 (63.1) 496 (66.9) 0.81 0.51 to 1.28 0.3554 Moderate stroke 704 (39.5) 122 (58.1) 899 (59.3) 1.23 0.71 to 2.13 0.4551 Severe stroke 245 (30.4) 59 (64.8) 416 (66.1) 1.12 0.58 to 2.17 0.7278 Interventional effect on sICH Mild stroke 17 (1.97) 4 (3.77) 13 (1.71) 2.71 0.80 to 7.69 0.1026 Moderate stroke 59 (3.31) 2 (0.94) 57 (3.63) 0.13 0.02 to 0.68 0.0159* Severe stroke 71 (8.80) 14 (13.3) 57 (8.12) 0.65 0.19 to 2.55 0.5180 Groups: mild: NIHSS 0–4; moderate: NIHSS 5–14; severe: NIHSS ≥15.
*P<0.05. Compared with those treated with standard dosage, patients treated with lower dosage of tPA have significantly less risk of sICH.
n1, number in low dose group; n2, number in standard dose group; n, total sample size in each group; NIHSS, National Institutes of Health Stroke Scale; sICH, symptomatic intracranial haemorrhage; tPA, tissue plasminogen activator.
- Table 2
Comparison of demographics and outcome among three subgroups
Mild stroke
n=865Moderate stroke
n=1784Severe stroke
n=807P value Number of lower dosage (%) 106 (12.25) 212 (11.88) 105 (13.01) 0.719 Age (years), n <0.001 <45 39 95 17 45–64 464 803 269 ≥65 357 872 515 Sex: male, n (%) 583 (67.40) 1193 (66.87) 463 (57.37) <0.0001 Median onset to needle, hours 2.933 2.833 2.667 <0.0001 History and risk factors, n (%) Hypertension 526 (60.81) 1051 (58.91) 503 (62.33) 0.235 Diabetes 185 (21.39) 378 (21.19) 156 (19.33) 0.496 Stroke 82 (9.48) 220 (12.33) 132 (16.36) 0.0001 TIA 17 (1.97) 71 (3.98) 37 (4.58) 0.008 Atrial fibrillation 59 (6.82) 266 (14.91) 273 (33.83) <0.0001 Outcome, n (%) sICH 17 (1.97) 59 (3.31) 71 (8.80） <0.0001 Clinical improvement 582 (67.3) 1080 (60.5) 475 (58.9) 0.0001 Groups: mild: NIHSS 0–4; moderate: NIHSS 5–14; severe: NIHSS ≥15.
NIHSS, National Institutes of Health Stroke Scale; sICH, symptomatic intracranial haemorrhage; TIA, transient ischaemic attack.
Supplementary data
