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Open Access

Thrombolysis with alteplase 3–4.5 hours after acute ischaemic stroke: the first multicentre, phase III trial in China

Huaguang Zheng, Yi Yang, Huisheng Chen, Chuanling Li, Yangkun Chen, Fu-Dong Shi, Li Yang, Xiaoping Cui, Zuneng Lu, Yanling Liang, Songbiao Cui, Anding Xu, Yiqing Wu, Yaqing Sun, Yongjun Wang
DOI: 10.1136/svn-2020-000337 Published 29 September 2020
Huaguang Zheng
1 Department of Neurology, Beijing Tiantan Hospital, Affiliated Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
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Yi Yang
3 Department of Neurology, The First Hospital of Jilin University, Changchun, China
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Huisheng Chen
4 Department of Neurology, General Hospital of Northern Theater Command, Shenyang, China
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Chuanling Li
5 Department of Neurology, Xuzhou Central Hospital, Xuzhou, China
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Yangkun Chen
6 Neurology, Dongguan People's Hospital, Dongguan, China
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Fu-Dong Shi
7 Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China
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Li Yang
7 Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China
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Xiaoping Cui
8 Department of Neurology, No.900 Hospital of Joint Logistics Support Force, Fuzhou, China
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Zuneng Lu
9 Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China
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Yanling Liang
10 Department of Neurology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
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Songbiao Cui
11 Department of Neurology, Yanbian University Hospital, Yanji, China
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Anding Xu
12 Neurology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, China
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Yiqing Wu
13 Boehringer Ingelheim (China) Investment Co., Ltd, Shanghai, China
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Yaqing Sun
13 Boehringer Ingelheim (China) Investment Co., Ltd, Shanghai, China
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Yongjun Wang
1 Department of Neurology, Beijing Tiantan Hospital, Affiliated Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
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Article Information

vol. 5 no. 3 285-290
DOI 
https://doi.org/10.1136/svn-2020-000337
PubMed 
32467323

Print ISSN 
2059-8688
Online ISSN 
2059-8696
History 
  • Received February 2, 2020
  • Revised April 11, 2020
  • Accepted April 15, 2020
  • Published online September 29, 2020.

Article Versions

  • Previous version (May 28, 2020 - 18:15).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

Author Information

  1. Huaguang Zheng1,2,
  2. Yi Yang3,
  3. Huisheng Chen4,
  4. Chuanling Li5,
  5. Yangkun Chen6,
  6. Fu-Dong Shi7,
  7. Li Yang7,
  8. Xiaoping Cui8,
  9. Zuneng Lu9,
  10. Yanling Liang10,
  11. Songbiao Cui11,
  12. Anding Xu12,
  13. Yiqing Wu13,
  14. Yaqing Sun13,
  15. Yongjun Wang1,2
  1. 1 Department of Neurology, Beijing Tiantan Hospital, Affiliated Capital Medical University, Beijing, China
  2. 2 China National Clinical Research Center for Neurological Diseases, Beijing, China
  3. 3 Department of Neurology, The First Hospital of Jilin University, Changchun, China
  4. 4 Department of Neurology, General Hospital of Northern Theater Command, Shenyang, China
  5. 5 Department of Neurology, Xuzhou Central Hospital, Xuzhou, China
  6. 6 Neurology, Dongguan People's Hospital, Dongguan, China
  7. 7 Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China
  8. 8 Department of Neurology, No.900 Hospital of Joint Logistics Support Force, Fuzhou, China
  9. 9 Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China
  10. 10 Department of Neurology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
  11. 11 Department of Neurology, Yanbian University Hospital, Yanji, China
  12. 12 Neurology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, China
  13. 13 Boehringer Ingelheim (China) Investment Co., Ltd, Shanghai, China
  1. Correspondence to Dr Yongjun Wang; yongjunwang{at}ncrcnd.org.cn
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Thrombolysis with alteplase 3–4.5 hours after acute ischaemic stroke: the first multicentre, phase III trial in China
Huaguang Zheng, Yi Yang, Huisheng Chen, Chuanling Li, Yangkun Chen, Fu-Dong Shi, Li Yang, Xiaoping Cui, Zuneng Lu, Yanling Liang, Songbiao Cui, Anding Xu, Yiqing Wu, Yaqing Sun, Yongjun Wang
Stroke and Vascular Neurology Sep 2020, 5 (3) 285-290; DOI: 10.1136/svn-2020-000337

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Thrombolysis with alteplase 3–4.5 hours after acute ischaemic stroke: the first multicentre, phase III trial in China
Huaguang Zheng, Yi Yang, Huisheng Chen, Chuanling Li, Yangkun Chen, Fu-Dong Shi, Li Yang, Xiaoping Cui, Zuneng Lu, Yanling Liang, Songbiao Cui, Anding Xu, Yiqing Wu, Yaqing Sun, Yongjun Wang
Stroke and Vascular Neurology Sep 2020, 5 (3) 285-290; DOI: 10.1136/svn-2020-000337
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Thrombolysis with alteplase 3–4.5 hours after acute ischaemic stroke: the first multicentre, phase III trial in China
Huaguang Zheng, Yi Yang, Huisheng Chen, Chuanling Li, Yangkun Chen, Fu-Dong Shi, Li Yang, Xiaoping Cui, Zuneng Lu, Yanling Liang, Songbiao Cui, Anding Xu, Yiqing Wu, Yaqing Sun, Yongjun Wang
Stroke and Vascular Neurology Sep 2020, 5 (3) 285-290; DOI: 10.1136/svn-2020-000337
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