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The Third China National Stroke Registry (CNSR-III) for patients with acute ischaemic stroke or transient ischaemic attack: design, rationale and baseline patient characteristics

Yongjun Wang, Jing Jing, Xia Meng, Yuesong Pan, Yilong Wang, Xingquan Zhao, Jinxi Lin, Wei Li, Yong Jiang, Zixiao Li, Xinmiao Zhang, Xiaomeng Yang, Ruijun Ji, Chunjuan Wang, Zhimin Wang, Xinsheng Han, Songdi Wu, Zhengchang Jia, Yongming Chen, Hao Li
DOI: 10.1136/svn-2019-000242 Published 23 September 2019
Yongjun Wang
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
3 Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
4 Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
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  • ORCID record for Yongjun Wang
Jing Jing
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
3 Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
4 Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
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Xia Meng
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
3 Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
4 Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
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Yuesong Pan
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
3 Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
4 Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
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Yilong Wang
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
3 Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
4 Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
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Xingquan Zhao
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
3 Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
4 Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
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Jinxi Lin
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
3 Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
4 Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
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Wei Li
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
3 Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
4 Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
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Yong Jiang
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
3 Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
4 Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
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Zixiao Li
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
3 Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
4 Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
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Xinmiao Zhang
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
3 Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
4 Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
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Xiaomeng Yang
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
3 Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
4 Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
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Ruijun Ji
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
3 Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
4 Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
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Chunjuan Wang
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
3 Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
4 Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
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Zhimin Wang
5 Department of Neurology, The First people’s Hospital of Taizhou, Taizhou, China
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Xinsheng Han
6 Department of Neurology, The Kaifeng Central Hospital, Kaifeng, China
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Songdi Wu
7 Department of Neurology, The First People’s Hospital of Xi’an, Xi’an, China
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Zhengchang Jia
8 Department of Neurology, The Second People’s Hospital of Jinzhong, Jinzhong, China
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Yongming Chen
9 Department of Neurology, WuYuan County People’s Hospital, Bayannur, China
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Hao Li
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing, China
3 Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
4 Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
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Figures

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    Figure 1

    The geographical locations of participating hospitals in the Third China National Stroke Registry.

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    Figure 2

    Flow chart of patient enrolment in the Third China National Stroke Registry. TIA, transient ischaemic attack.

Tables

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  • Table 1

    Characteristics of participating hospitals in CNSR-III (n=201)

    Characteristics
    Hospital type
    Grade II38 (18.9)
    Grade III163 (81.1)
    Infrastructures
    Beds in total (n) 1263 (1000–2000)
    Beds in Neurology department (ND) (n)108 (72-180)
    Stroke out-patients clinic172 (85.6)
    Emergency department201 (100.0)
    NICU144 (71.6)
    Stroke unit155 (77.1)
    Inpatients’ rehabilitation199 (99.0)
    Neurological rehabilitation department158 (78.6)
    Personnel
    Neurological rehabilitators176 (87.6)
    Speech therapist151 (75.1)
    Physiotherapist193 (96.0)
    Diagnostic procedures
    Brain CT scan 24/7201 (100.0)
    Digital subtraction angiography185 (92.0)
    Extracranial duplex sonography195 (97.0)
    • CNSR-III, the Third China National Stroke Registry; NICU, neonatal intensive care unit.

  • Table 2

    Baseline characteristics of the included patients in CNSR-III (n=15 166)

    Characteristics
    Age (yr), mean±SD62.2±11.3
    Female, n(%)4802 (31.7)
    Ethnicity (non-Han), n (%)440 (2.9)
    Education, n(%)
     Elementary or below4292 (28.3)
     Middle school4405 (29.1)
     High school or above4282 (28.2)
     Unkown2187 (14.4)
    Current smoker, n(%)4752 (31.3)
    Heavy drinker, n(%)*2126 (14.0)
    Medical history, n(%)
     Ischaemic stroke3149 (20.8)
     Coronary heart diseases1608 (10.6)
     Atrial fibrillation1019 (6.7)
     Hypertension9494 (62.6)
     Diabetes mellitus3510 (23.1)
     Hypercholesterolemia1191 (7.9)
    Days from event onset to enrolment, median (IQR)2.0 (1.0–4.0)
    NIHSS at admission, median (IQR)3 (1–6)
    Stroke type
    TIA1020 (6.7)
    IS14 146 (93.3)
    NIHSS 0–37319 (51.7)
    NIHSS≥46827 (48.3)
    • *Heavy drinker was defined as ≥2 standard alcohol consumption/per day. 

    • CNSR-III, the Third China National Stroke Registry; IS, ischaemic stroke; NIHSS, National Institutes of Health Stroke Scale score; TIA, transient ischaemic attack.

  • Table 3

    Comparison of CNSR-III with CNSR-I and CNSR-II

    CharacteristicCNSR-ICNSR-IICNSR-III
    Published year20112016-
    Study year2007–20082012–20132015–2018
    Patients (n)21 90225 01815 166
    Sites (n)132219201
    Age(yr), mean±SD63.8±12.964.3±12.262.2±11.3
    Female (%)38.837.431.7
    Onset to admission (days)≤14≤7≤7
    Disease subtypes
    IS (%)66.478.493.3
    TIA (%)6.27.96.7
    ICH (%)23.412.1-
    SAH (%)3.41.2-
    Imaging and biological sample collectionNoNoYes
    Follow-up (years)115
    • CNSR, China National Stroke Registry; ICH, intracerebral haemorrhage; IS, ischaemic stroke; SAH, subarachnoid haemorrhage; TIA, transient ischaemic attack.

Supplementary Materials

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    [svn-2019-000242supp001.pdf]

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The Third China National Stroke Registry (CNSR-III) for patients with acute ischaemic stroke or transient ischaemic attack: design, rationale and baseline patient characteristics
Yongjun Wang, Jing Jing, Xia Meng, Yuesong Pan, Yilong Wang, Xingquan Zhao, Jinxi Lin, Wei Li, Yong Jiang, Zixiao Li, Xinmiao Zhang, Xiaomeng Yang, Ruijun Ji, Chunjuan Wang, Zhimin Wang, Xinsheng Han, Songdi Wu, Zhengchang Jia, Yongming Chen, Hao Li
Stroke and Vascular Neurology Sep 2019, 4 (3) 158-164; DOI: 10.1136/svn-2019-000242

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The Third China National Stroke Registry (CNSR-III) for patients with acute ischaemic stroke or transient ischaemic attack: design, rationale and baseline patient characteristics
Yongjun Wang, Jing Jing, Xia Meng, Yuesong Pan, Yilong Wang, Xingquan Zhao, Jinxi Lin, Wei Li, Yong Jiang, Zixiao Li, Xinmiao Zhang, Xiaomeng Yang, Ruijun Ji, Chunjuan Wang, Zhimin Wang, Xinsheng Han, Songdi Wu, Zhengchang Jia, Yongming Chen, Hao Li
Stroke and Vascular Neurology Sep 2019, 4 (3) 158-164; DOI: 10.1136/svn-2019-000242
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The Third China National Stroke Registry (CNSR-III) for patients with acute ischaemic stroke or transient ischaemic attack: design, rationale and baseline patient characteristics
Yongjun Wang, Jing Jing, Xia Meng, Yuesong Pan, Yilong Wang, Xingquan Zhao, Jinxi Lin, Wei Li, Yong Jiang, Zixiao Li, Xinmiao Zhang, Xiaomeng Yang, Ruijun Ji, Chunjuan Wang, Zhimin Wang, Xinsheng Han, Songdi Wu, Zhengchang Jia, Yongming Chen, Hao Li
Stroke and Vascular Neurology Sep 2019, 4 (3) 158-164; DOI: 10.1136/svn-2019-000242
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