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The Third China National Stroke Registry (CNSR-III) for patients with acute ischaemic stroke or transient ischaemic attack: design, rationale and baseline patient characteristics

Yongjun Wang, Jing Jing, Xia Meng, Yuesong Pan, Yilong Wang, Xingquan Zhao, Jinxi Lin, Wei Li, Yong Jiang, Zixiao Li, Xinmiao Zhang, Xiaomeng Yang, Ruijun Ji, Chunjuan Wang, Zhimin Wang, Xinsheng Han, Songdi Wu, Zhengchang Jia, Yongming Chen, Hao Li
DOI: 10.1136/svn-2019-000242 Published 29 June 2019
Yongjun Wang
1China National Clinical Research Center for Neurological Diseases, Beijing, China
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Jing Jing
1China National Clinical Research Center for Neurological Diseases, Beijing, China
2Neurology, Tiantan Clinical Trial and Research Center for Stroke, Beijing, China
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Xia Meng
1China National Clinical Research Center for Neurological Diseases, Beijing, China
3Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Beijing, China
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Yuesong Pan
1China National Clinical Research Center for Neurological Diseases, Beijing, China
4Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Yilong Wang
1China National Clinical Research Center for Neurological Diseases, Beijing, China
2Neurology, Tiantan Clinical Trial and Research Center for Stroke, Beijing, China
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Xingquan Zhao
1China National Clinical Research Center for Neurological Diseases, Beijing, China
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Jinxi Lin
1China National Clinical Research Center for Neurological Diseases, Beijing, China
5Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Wei Li
1China National Clinical Research Center for Neurological Diseases, Beijing, China
5Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Yong Jiang
1China National Clinical Research Center for Neurological Diseases, Beijing, China
6Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Zixiao Li
1China National Clinical Research Center for Neurological Diseases, Beijing, China
7Neurology, Tiantan Clinical Trial and Research Center for Stroke, Beijing, China
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Xinmiao Zhang
1China National Clinical Research Center for Neurological Diseases, Beijing, China
8Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Xiaomeng Yang
1China National Clinical Research Center for Neurological Diseases, Beijing, China
5Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Ruijun Ji
1China National Clinical Research Center for Neurological Diseases, Beijing, China
9Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Chunjuan Wang
1China National Clinical Research Center for Neurological Diseases, Beijing, China
10Department of Neurology, Beijing Tiantan Hospital, Beijing, China
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Zhimin Wang
11The First people’s Hospital of Taizhou, Taizhou, China
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Xinsheng Han
12The Kaifeng Central Hospital, Kaifeng, China
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Songdi Wu
13The First People’s Hospital of Xi’an, Xi’an, China
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Zhengchang Jia
14The Second People’s Hospital of Jinzhong, Jinzhong, China
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Yongming Chen
15WuYuan County People’s Hospital, Bayannur, China
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Hao Li
1China National Clinical Research Center for Neurological Diseases, Beijing, China
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Article Figures & Data

Figures

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  • Figure 1
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    Figure 1

    The geographical locations of participating hospitals in the Third China National Stroke Registry.

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    Figure 2

    Flow chart of patient enrolment in the Third China National Stroke Registry. TIA, transient ischaemic attack.

Tables

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  • Table 1

    Characteristics of participating hospitals in CNSR-III (n=201)

    Characteristics
    Hospital type
    Grade II38 (18.9)
    Grade III163 (81.1)
    Infrastructures
    Beds in total (n) 1263 (1000–2000)
    Beds in Neurology department (ND) (n)108 (72-180)
    Stroke out-patients clinic172 (85.6)
    Emergency department201 (100.0)
    NICU144 (71.6)
    Stroke unit155 (77.1)
    Inpatients’ rehabilitation199 (99.0)
    Neurological rehabilitation department158 (78.6)
    Personnel
    Neurological rehabilitators176 (87.6)
    Speech therapist151 (75.1)
    Physiotherapist193 (96.0)
    Diagnostic procedures
    Brain CT scan 24/7201 (100.0)
    Digital subtraction angiography185 (92.0)
    Extracranial duplex sonography195 (97.0)
    • CNSR-III, the Third China National Stroke Registry; NICU, neonatal intensive care unit.

  • Table 2

    Baseline characteristics of the included patients in CNSR-III (n=15 166)

    Characteristics
    Age (yr), mean±SD62.2±11.3
    Female, n(%)4802 (31.7)
    Ethnicity (non-Han), n (%)440 (2.9)
    Education, n(%)
     Elementary or below4292 (28.3)
     Middle school4405 (29.1)
     High school or above4282 (28.2)
     Unkown2187 (14.4)
    Current smoker, n(%)4752 (31.3)
    Heavy drinker, n(%)*2126 (14.0)
    Medical history, n(%)
     Ischaemic stroke3149 (20.8)
    Coronary heart diseases1608 (10.6)
    Atrial fibrillation1019 (6.7)
    Hypertension9494 (62.6)
    Diabetes mellitus3510 (23.1)
    Hypercholesterolemia1191 (7.9)
    Days from event onset to enrolment, median (IQR)2.0 (1.0–4.0)
    NIHSS at admission, median (IQR)3 (1–6)
    Stroke type
    TIA1020 (6.7)
    IS14 146 (93.3)
    NIHSS 0–37319 (51.7)
    NIHSS≥46827 (48.3)
    • *Heavy drinker was defined as ≥2 standard alcohol consumption/per day. 

    • CNSR-III, the Third China National Stroke Registry; IS, ischaemic stroke; NIHSS, National Institutes of Health Stroke Scale score; TIA, transient ischaemic attack.

  • Table 3

    Comparison of CNSR-III with CNSR-I and CNSR-II

    CharacteristicCNSR-ICNSR-IICNSR-III
    Published year20112016-
    Study year2007–20082012–20132015–2018
    Patients (n)21 90225 01815 166
    Sites (n)132219201
    Age(yr), mean±SD63.8±12.964.3±12.262.2±11.3
    Female (%)38.837.431.7
    Onset to admission (days)≤14≤7≤7
    Disease subtypes
    IS (%)66.478.493.3
    TIA (%)6.27.96.7
    ICH (%)23.412.1-
    SAH (%)3.41.2-
    Imaging and biological sample collectionNoNoYes
    Follow-up (years)115
    • CNSR, China National Stroke Registry; ICH, intracerebral haemorrhage; IS, ischaemic stroke; SAH, subarachnoid haemorrhage; TIA, transient ischaemic attack.

Supplementary Materials

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    [svn-2019-000242supp001.pdf]

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The Third China National Stroke Registry (CNSR-III) for patients with acute ischaemic stroke or transient ischaemic attack: design, rationale and baseline patient characteristics
Yongjun Wang, Jing Jing, Xia Meng, Yuesong Pan, Yilong Wang, Xingquan Zhao, Jinxi Lin, Wei Li, Yong Jiang, Zixiao Li, Xinmiao Zhang, Xiaomeng Yang, Ruijun Ji, Chunjuan Wang, Zhimin Wang, Xinsheng Han, Songdi Wu, Zhengchang Jia, Yongming Chen, Hao Li
Stroke and Vascular Neurology Jun 2019, svn-2019-000242; DOI: 10.1136/svn-2019-000242

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The Third China National Stroke Registry (CNSR-III) for patients with acute ischaemic stroke or transient ischaemic attack: design, rationale and baseline patient characteristics
Yongjun Wang, Jing Jing, Xia Meng, Yuesong Pan, Yilong Wang, Xingquan Zhao, Jinxi Lin, Wei Li, Yong Jiang, Zixiao Li, Xinmiao Zhang, Xiaomeng Yang, Ruijun Ji, Chunjuan Wang, Zhimin Wang, Xinsheng Han, Songdi Wu, Zhengchang Jia, Yongming Chen, Hao Li
Stroke and Vascular Neurology Jun 2019, svn-2019-000242; DOI: 10.1136/svn-2019-000242
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The Third China National Stroke Registry (CNSR-III) for patients with acute ischaemic stroke or transient ischaemic attack: design, rationale and baseline patient characteristics
Yongjun Wang, Jing Jing, Xia Meng, Yuesong Pan, Yilong Wang, Xingquan Zhao, Jinxi Lin, Wei Li, Yong Jiang, Zixiao Li, Xinmiao Zhang, Xiaomeng Yang, Ruijun Ji, Chunjuan Wang, Zhimin Wang, Xinsheng Han, Songdi Wu, Zhengchang Jia, Yongming Chen, Hao Li
Stroke and Vascular Neurology Jun 2019, svn-2019-000242; DOI: 10.1136/svn-2019-000242
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