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Treatment with intravenous alteplase in ischaemic stroke patients with onset time between 4.5 and 24 hours (HOPE): protocol for a randomised, controlled, multicentre study

Zhongyu Luo, Ying Zhou, Yaode He, Shenqiang Yan, Zhicai Chen, Xuting Zhang, Yi Chen, Lu-Sha Tong, Wansi Zhong, Haitao Hu, Kemeng Zhang, Jiansheng Yang, Bruce C V Campbell, Min Lou
DOI: 10.1136/svn-2022-002154 Published 21 June 2024
Zhongyu Luo
1 Department of Neurology, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China
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Ying Zhou
1 Department of Neurology, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China
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Yaode He
1 Department of Neurology, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China
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Shenqiang Yan
1 Department of Neurology, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China
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Zhicai Chen
1 Department of Neurology, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China
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Xuting Zhang
1 Department of Neurology, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China
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Yi Chen
1 Department of Neurology, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China
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Lu-Sha Tong
1 Department of Neurology, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China
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Wansi Zhong
1 Department of Neurology, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China
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Haitao Hu
1 Department of Neurology, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China
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Kemeng Zhang
1 Department of Neurology, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China
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Jiansheng Yang
1 Department of Neurology, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China
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Bruce C V Campbell
2 Department of Medicine and Neurology, Melbourne Brain Centre at Royal Melbourne Hospital, Parkville, Victoria, Australia
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Min Lou
1 Department of Neurology, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China
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Article Information

vol. 9 no. 3 318-323
DOI 
https://doi.org/10.1136/svn-2022-002154
PubMed 
37527920

Print ISSN 
2059-8688
Online ISSN 
2059-8696
History 
  • Received November 11, 2022
  • Accepted July 6, 2023
  • Published online June 21, 2024.

Article Versions

  • Previous version (August 1, 2023 - 08:29).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

Author Information

  1. Zhongyu Luo1,
  2. Ying Zhou1,
  3. Yaode He1,
  4. Shenqiang Yan1,
  5. Zhicai Chen1,
  6. Xuting Zhang1,
  7. Yi Chen1,
  8. Lu-Sha Tong1,
  9. Wansi Zhong1,
  10. Haitao Hu1,
  11. Kemeng Zhang1,
  12. Jiansheng Yang1,
  13. Bruce C V Campbell2,
  14. Min Lou1
  1. 1 Department of Neurology, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China
  2. 2 Department of Medicine and Neurology, Melbourne Brain Centre at Royal Melbourne Hospital, Parkville, Victoria, Australia
  1. Correspondence to Dr Min Lou; lm99{at}zju.edu.cn
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Stroke and Vascular Neurology: 9 (3)
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Treatment with intravenous alteplase in ischaemic stroke patients with onset time between 4.5 and 24 hours (HOPE): protocol for a randomised, controlled, multicentre study
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Treatment with intravenous alteplase in ischaemic stroke patients with onset time between 4.5 and 24 hours (HOPE): protocol for a randomised, controlled, multicentre study
Zhongyu Luo, Ying Zhou, Yaode He, Shenqiang Yan, Zhicai Chen, Xuting Zhang, Yi Chen, Lu-Sha Tong, Wansi Zhong, Haitao Hu, Kemeng Zhang, Jiansheng Yang, Bruce C V Campbell, Min Lou
Stroke and Vascular Neurology Jun 2024, 9 (3) 318-323; DOI: 10.1136/svn-2022-002154

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Treatment with intravenous alteplase in ischaemic stroke patients with onset time between 4.5 and 24 hours (HOPE): protocol for a randomised, controlled, multicentre study
Zhongyu Luo, Ying Zhou, Yaode He, Shenqiang Yan, Zhicai Chen, Xuting Zhang, Yi Chen, Lu-Sha Tong, Wansi Zhong, Haitao Hu, Kemeng Zhang, Jiansheng Yang, Bruce C V Campbell, Min Lou
Stroke and Vascular Neurology Jun 2024, 9 (3) 318-323; DOI: 10.1136/svn-2022-002154
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Treatment with intravenous alteplase in ischaemic stroke patients with onset time between 4.5 and 24 hours (HOPE): protocol for a randomised, controlled, multicentre study
Zhongyu Luo, Ying Zhou, Yaode He, Shenqiang Yan, Zhicai Chen, Xuting Zhang, Yi Chen, Lu-Sha Tong, Wansi Zhong, Haitao Hu, Kemeng Zhang, Jiansheng Yang, Bruce C V Campbell, Min Lou
Stroke and Vascular Neurology Jun 2024, 9 (3) 318-323; DOI: 10.1136/svn-2022-002154
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