Rationale and design of a randomised double-blind 2×2 factorial trial comparing the effect of a 3-month intensive statin and antiplatelet therapy for patients with acute mild ischaemic stroke or high-risk TIA with intracranial or extracranial atherosclerosis (INSPIRES)

Ying Gao; Yuesong Pan; Shangrong Han; Weiqi Chen; Jing Jing; Chunjuan Wang; Yingying Yang; Tingting Wang; Xia Meng; Xingquan Zhao; Liping Liu; Hao Li; S Claiborne Johnston; Pierre Amarenco; Philip M Bath; Yongjun Wang; Yilong Wang

doi:10.1136/svn-2022-002084

Open Access

Rationale and design of a randomised double-blind 2×2 factorial trial comparing the effect of a 3-month intensive statin and antiplatelet therapy for patients with acute mild ischaemic stroke or high-risk TIA with intracranial or extracranial atherosclerosis (INSPIRES)

Ying Gao, Yuesong Pan, Shangrong Han, Weiqi Chen, Jing Jing, Chunjuan Wang, Yingying Yang, Tingting Wang, Xia Meng, Xingquan Zhao, Liping Liu, Hao Li, S Claiborne Johnston, Pierre Amarenco, Philip M Bath, Yongjun Wang, Yilong Wang

DOI: 10.1136/svn-2022-002084 Published 23 June 2023

Ying Gao

1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Yuesong Pan

1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

2 China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Shangrong Han

1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Weiqi Chen

1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Jing Jing

1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

2 China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Chunjuan Wang

1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

2 China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Yingying Yang

1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Tingting Wang

1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Xia Meng

1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

2 China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Xingquan Zhao

1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

2 China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Liping Liu

1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

2 China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Hao Li

1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

2 China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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S Claiborne Johnston

3 Dean's Office, Dell Medical School, University of Texas at Austin, Austin, Texas, USA

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Pierre Amarenco

4 Department of Neurology and Stroke Center, Assistance Publique-Hôpitaux de Paris (APHP), Bichat Hospital, INSERM LVTS-U1148, University of Paris, Paris, France

5 Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada

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Philip M Bath

6 Stroke Trials Unit, Mental Health & Clinical Neuroscience, University of Nottingham, Nottingham, UK

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Yongjun Wang

1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

2 China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

7 Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China

8 National Center for Neurological Diseases, Beijing, China

9 Research Unit of Artificial Intelligence in Cerebrovascular Disease, Chinese Academy of Medical Sciences, Beijing, China

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Yilong Wang

1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

2 China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

7 Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China

8 National Center for Neurological Diseases, Beijing, China

10 Chinese Institute for Brain Research, Beijing, China

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Rationale and design of a randomised double-blind 2×2 factorial trial comparing the effect of a 3-month intensive statin and antiplatelet therapy for patients with acute mild ischaemic stroke or high-risk TIA with intracranial or extracranial atherosclerosis (INSPIRES)