Article Figures & Data
Figures
- Figure 1
(A) An example of the pathway between WMH progression on MRI and dementia/MCI, (B) predicted probability* of incident dementia/MCI for ±2 Z scores of WMH progression. *Adjusted for baseline WMH volume, total intracranial volume, patient race, retirement status and randomisation arm. MCI, mild cognitive impairment; WMH, white matter hyperintensity.
Tables
- Table 1
Baseline demographics and MRI volumes, stratified by the WMH progression threshold of ≥1.4 mL vs <1.4 mL
Variable Full cohort
(N=433)WMH progression ≥1.4 mL
(n=156)WMH progression <1.4 mL
(n=277)P value* Age 67.3±7.8 69.7±8.0 65.9±7.3 <0.001 Male sex 272 (62.8%) 90 (57.7%) 182 (65.7%) 0.098 Race/ethnicity 0.730 White 277 (64.0%) 97 (62.2%) 180 (65.0%) Black 132 (30.5%) 52 (33.3%) 80 (28.9%) Hispanic 20 (4.6%) 6 (3.9%) 14 (5.1%) Other 4 (0.9%) 1 (0.6%) 3 (1.1) History of cardiovascular disease 50 (11.6%) 25 (16.0%) 25 (9.0%) 0.029 History of diabetes 9 (2.1%) 5 (3.2%) 4 (1.4%) 0.294 History of peripheral vascular disease 24 (5.5%) 7 (4.5%) 17 (6.1%) 0.471 History of atrial fibrillation 29 (6.7%) 10 (6.4%) 19 (6.9%) 0.858 Smoking (n=432) 0.050 Never 197 (45.6%) 59 (37.8%) 138 (50.0%) Past 180 (41.7%) 75 (48.1%) 105 (38.0%) Current 55 (12.7%) 22 (14.1%) 33 (12.0%) Alcoholism 10 (2.3%) 3 (1.9%) 7 (2.5%) 1.000 Vigorous phsycial activities 0.817 ≤1 /week 219 (50.6%) 82 (52.6%) 137 (49.5%) 1–4/week 152 (35.1%) 53 (34.0%) 99 (35.7%) ≥5 /week 62 (14.3%) 21 (13.4%) 41 (14.8%) Aspirin use 217 (50.1%) 85 (54.5%) 132 (47.7%) 0.172 Retired 250 (57.7%) 100 (64.1%) 150 (54.2%) 0.044 Education 0.042 <College or other 250 (57.7%) 101 (64.7%) 149 (53.8%) College 69 (16.0%) 17 (10.9%) 52 (18.9%) Graduate school 114 (26.3%) 38 (24.4%) 76 (27.4%) Randomised to intensive blood pressure reduction 241 (55.7%) 73 (46.8%) 168 (60.7%) 0.005 Baseline WMH volume (mL) 5.8±7.4 9.7±9.3 3.6±4.9 <0.001 Baseline total intracranial volume (mL) 1391±144 1397±146 1388±143 0.558 *P value shown for comparison between WMH progression stratification and calculated with Student’s t-test for interval variables and the χ2 or Fisher’s exact test for binary variables, depending on frequency; interval variables shown as mean±SD and binary variables as n (%).
WMH, white matter hyperintensity.
