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Cerebral venous sinus thrombosis after ChAdOx1 nCov-19 vaccination with a misleading first cerebral MRI scan

Benno Ikenberg, Antonia Franziska Demleitner, Thomas Thiele, Benedikt Wiestler, Katharina Götze, Georg Mößmer, Paul Lingor
DOI: 10.1136/svn-2021-001095 Published 24 December 2021
Benno Ikenberg
1 Department of Neurology, Klinikum rechts der Isar der Technischen Universität München, Munchen, Germany
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Antonia Franziska Demleitner
1 Department of Neurology, Klinikum rechts der Isar der Technischen Universität München, Munchen, Germany
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Thomas Thiele
2 Institut für Immunologie und Transfusionsmedizin, Universitätsmedizin Greifswald, Greifswald, Germany
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Benedikt Wiestler
3 Department of Diagnostic und Interventional Neuroradiology, Klinikum rechts der Isar der Technischen Universität München, Munchen, Germany
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Katharina Götze
4 Department of Medicine III, Klinikum rechts der Isar der Technischen Universität München, Munchen, Germany
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Georg Mößmer
5 Institute for Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar der Technischen Universität München, Munchen, Germany
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Paul Lingor
1 Department of Neurology, Klinikum rechts der Isar der Technischen Universität München, Munchen, Germany
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    Figure 1

    A time course of clinical characteristics and laboratory results following vaccination. Platelet count is depicted in red. The value of day 9 prior to second presentation in our hospital was provided by the generalist. Headache intensity is shown in black according to the Numerical Rating Scale. (B) Serial cerebral MRI scans. Upper row: axial T2* sequence of the infratentorial brain; lower row: coronal T1w sequence of the cerebellum, temporal lobe and sinus transversus. (B-1) MRI scan at first presentation in our emergency department with thrombocytopenia and headache. At first look, the MRI scan was without a clear sign for CVST. Retrospectively (red arrows), a slight irregularity as indicator of beginning thrombosis may be discussed. (B-2) First follow-up MRI 3 days later revealed a CVST of the left transverse and sigmoidal sinus (red arrows) with a left-temporal and left cerebellar intracerebral haemorrhage (asterisks). (B-3) Most recent follow-up MRI showing a persisting CVST and intracerebral haemorrhage with a slightly progressive perifocal oedema. Volume of cerebellar haemorrhage slightly decreased. CVST, cerebral venous sinus thrombosis; ER, emergency room; HIPA, heparin-induced platelet activation assay; HIT, heparin-induced thrombocytopenia; IVIG, intravenous immunoglobulin; PIPA, platelet-factor-4-induced platelet activation assay.

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Stroke and Vascular Neurology: 6 (4)
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Cerebral venous sinus thrombosis after ChAdOx1 nCov-19 vaccination with a misleading first cerebral MRI scan
Benno Ikenberg, Antonia Franziska Demleitner, Thomas Thiele, Benedikt Wiestler, Katharina Götze, Georg Mößmer, Paul Lingor
Stroke and Vascular Neurology Dec 2021, 6 (4) 668-670; DOI: 10.1136/svn-2021-001095

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Cerebral venous sinus thrombosis after ChAdOx1 nCov-19 vaccination with a misleading first cerebral MRI scan
Benno Ikenberg, Antonia Franziska Demleitner, Thomas Thiele, Benedikt Wiestler, Katharina Götze, Georg Mößmer, Paul Lingor
Stroke and Vascular Neurology Dec 2021, 6 (4) 668-670; DOI: 10.1136/svn-2021-001095
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Cerebral venous sinus thrombosis after ChAdOx1 nCov-19 vaccination with a misleading first cerebral MRI scan
Benno Ikenberg, Antonia Franziska Demleitner, Thomas Thiele, Benedikt Wiestler, Katharina Götze, Georg Mößmer, Paul Lingor
Stroke and Vascular Neurology Dec 2021, 6 (4) 668-670; DOI: 10.1136/svn-2021-001095
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