Article Figures & Data
Figures
- Figure 1
Flow chart of studies included.
Tables
- Table 1
Relationship between serum bilirubin and ischaemic stroke outcomes
Study Outcomes reported Major findings Outcome 1 Unit Follow-up point (days) Outcome 2 Unit Follow-up point (days) Outcome 3 Unit Follow-up point (days) Bhatia et al 65 Death Mortality 30 Bilirubin did not differ significantly in the survivors and expired stroke patients. Perlstein et al 35 Adverse stroke outcomes A ‘Physical
Function’ questionnaire1 Higher TBIL level is associated with improved stroke outcomes. Pineda et al 61 Neurological impairment NIHSS score 1 Death or disability mRS At discharge Poor functional outcome mRS score >3 At discharge Higher DBIL level is associated with greater stroke severity but not functional outcome among ischaemic stroke patients. Kurzepa et al 54 Functional disability BI score 90 Neurological impairment NIHSS score 1, 3, 5 and 10 Serum bilirubin levels are poor prognostic factors for ischaemic stroke. Arsalan et al 53 Neurological impairment NIHSS score 7.25 (at discharge) Death or disability mRS 7.25 (at discharge) Poor functional outcome mRS score was from 4 to 6 7.25 (at discharge) Higher serum bilirubin levels were associated with increased stroke severity, longer hospitalisation and poor prognosis. Luo et al 57 Neurological impairment NIHSS score 1 Relative severe stroke NIHSS score ≥8 1 Serum bilirubins were in significant correlation with severity of AIS. Luo et al 3 Neurological impairment NIHSS score 1 Relative severe stroke NIHSS score ≥8 1 The serum levels of DBIL and TBIL were increased after AIS, which linked to the severity of stroke. Markaki et al 60 Death Mortality 28 months Bilirubin is an independent predictor of mortality in ischaemic cerebrovascular disease patients (ischaemic stroke and transient ischaemic attack). Xu et al 58 Neurological impairment NIHSS score 1 Higher severity NIHSS score ≥10 1 Short-term clinical outcomes NIHSS ≥10 at discharge or in-hospital death At discharge Serum bilirubin levels were associated with initial stroke severity closely but not short-term clinical outcomes among AIS patients. Ademiluyi et al 56 Neurological impairment NIHSS score 1 Severe stroke NIHSS score >14 1 AIS patients with higher physiological range of serum bilirubin had more severe stroke (higher NIHSS values). Sagheb Asl et al 59 Death Mortality 14 TBIL, DBIL and IBIL levels were significantly associated with mortality in AIS patients. Wang et al 55 Neurological impairment NIHSS score 1, 7 and 14 Disability mRS 30 Poor functional outcome mRS score >3 30 Hyperbilirubinaemia might be a biomarker for a poor prognosis in the early identification of LAA strokes. AIS, acute ischaemic stroke; BI, Barthel Index; DBIL, direct bilirubin; IBIL, indirect bilirubin; LAA, large-artery atherosclerosis; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; TBIL, total serum bilirubin.
Vol 5 Issue 2
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