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Mechanical thrombectomy in children and adolescents: report of five cases and literature review

Pervinder Bhogal, Victoria Hellstern, Muhammad AlMatter, Oliver Ganslandt, Hansjörg Bäzner, Marta Aguilar Pérez, Hans Henkes
DOI: 10.1136/svn-2018-000181 Published 21 December 2018
Pervinder Bhogal
1 Department of Interventional Neuroradiology, Royal London Hospital, London, UK
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Victoria Hellstern
2 Neuroradiological Clinic, Neurocenter, Klinikum Stuttgart, Stuttgart, Germany
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Muhammad AlMatter
2 Neuroradiological Clinic, Neurocenter, Klinikum Stuttgart, Stuttgart, Germany
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Oliver Ganslandt
3 Neurosurgical Clinic, Neurocenter, Klinikum Stuttgart, Stuttgart, Germany
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Hansjörg Bäzner
4 Neurosurgical Clinic, Neurocenter, Klinikum Stuttgart, Stuttgart, Germany
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Marta Aguilar Pérez
2 Neuroradiological Clinic, Neurocenter, Klinikum Stuttgart, Stuttgart, Germany
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Hans Henkes
2 Neuroradiological Clinic, Neurocenter, Klinikum Stuttgart, Stuttgart, Germany
5 Medical Faculty, University Duisburg-Essen, Duisburg, Germany
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    Figure 1

    An area of restricted diffusion was seen in the basal ganglia on the left (A) with confirmation of the suspected carotid T-occlusion seen on catheter angiography (B, C). After a single pass with a pREset 4×20 mm stent retriever there was complete recanalisation of the left M1 with only a single opercular branch still occluded (thrombolysis in cerebral infarction (TICI) 2b) (D). The procedure was terminated at this point. An MRI scan performed at 24 hours (E) showed an infarction within the left basal ganglia.

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    Figure 2

    An MRI demonstrated hyperintense signal within the M2 and M3 branches of the left middle cerebral artery (MCA) consistent with slow flow (A). Angiography demonstrated an acute occlusion of the left terminal M1 segment (B). After an initial aspiration thrombectomy attempt the M1 segment was recanalised, however, further thrombus was seen in the M2 branches and therefore further stent retriever mechanical thrombectomy was performed using a Solitaire 4×20 mm resulting in thrombolysis in cerebral infarction (TICI) 2b recanalisation (C).

Tables

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  • Table 1

    Summary of the presenting NIHSS, imaging findings, relevant timings and 90-day mRS

    Patient NoDemographicsNIHSSImagingTimingmRS
    AgeGenderModalityClot locationASPECTSDuration of treatmentTime to recanalisation
    117F9CT and MRI+TOFLeft carotid T71284452
    211F2MRI+TOFLeft M19493540
    316M15CT+CTALeft M171042422
    47M7MRI+TOFLeft V4 segmentNA56NA1
    515F23MRI+TOFLeft carotid T8212900
    • ASPECTS, Alberta Stroke Program Early CT Score; CTA, CT angiogram; mRS, modified Rankin Scale; NA, not applicable; NIHSS, National Institutes of Health Stroke Scale; TOF, time-of-flight.

  • Table 2

    A summary of the equipment used in each case

    Patient NoAccessSheathGuide catheterDistal access catheterFlow reversalMicrocatheterStent retriever/aspiration catheter/otherComplications
    1Right CFA8Fr short sheath8Fr Vista Brite Tip5Fr SofiaYes—manualVelocity4×20 mm pREset, 3×20 mm pREset LTN
    2Right CFA8Fr short sheath8Fr Guider SoftipReFlexYes—manualProwler Select Plus3×30 mm SolitaireN
    3Right CFA8Fr short sheath8Fr Guider SoftipReFlexYes—manualProwler Select Plus3×30 mm SolitaireN
    4Right CFA6Fr short sheath6Fr EnvoyNAYes—manualProwler Select PlusNo—AlligatorN
    5Right CFA8Fr short sheath8Fr Guider SoftipACE 68Yes—manualNAACE 68N
    • CFA, common femoral artery; NA, not applicable.

  • Table 3

    Summary of the published mechanical thrombectomy cases performed in the paediatric age group

    AuthorsAgeSexNIHSSThrombus locationTreatment deviceFlow restorationClinical outcome
    Vega et al 44 11M16R M1 segment of MCATrevo stent+PenumbraY—TICI 2 cNIHSS 7, 9 days post-op
    Huded et al 45 6M15Both vertebral arteries+basilar arterySolitaire stentY—TICI 2 c/3NIHSS 0 at discharge, non-ambulatory at 3 months
    Savastano et al 46 22 monthsFNABasilar arterySolitaire stentY—TICI 3Neurologically intact
    Stidd and Lopes47 2MNAR M1 segment of MCATrevoY—TICI 2bImprovement in hemiplegia, mild deficit in left hand and facial droop at 30 days
    Ladner et al 48 5M22Basilar arterySolitaire stentY—TICI 2bNIHSS 0 at 6 weeks
    Sainz de la Maza et al 49 12F18R M1 segment of MCASolitaire stentY—TICI 2 cNIHSS 1 at 3 months
    Bodey et al 40 10M27Basilar arteryReviveY—TICI 3Left hemiparesis and impaired cognition at 6 months, mRS 3
    5M29Basilar arterySolitaire stentY—TICI 3Ataxia at 6 months, mRS 2
    6M28Basilar arterySolitaire stentY—TICI 2bNo motor deficit, mRS 0
    15M21L MCASolitaire stentNA—TICI 3?No deficit, mRS 0 at 6 months
    Dubedout et al 50 7M20Basilar arteryCapture stentY—TICI 3NIHSS 0 at discharge
    Fink et al 51 116Basilar arterySolitaireY—TICI 3Slight dysarthria at 3 months
    Xavier et al 52 1611R ICAPenumbra+Wingspan stentNANIHSS 1 at 3 months
    Huded et al 45 7M17R ICASolitaire stent+PenumbraY—TICI 2aNIHSS 2 at 3 months
    9F17L ICASolitaire stent+PenumbraY—TICI 2bNIHSS 1 at 3 months
    Grunwald et al 53 16F36Basilar arteryPenumbraY—TICI 3NIHSS 23 at 1 month
    7M26L ICAPenumbraY—TICI 3NIHSS 0 at 1 month
    16F26L M1 segment of MCAPhenox stentPartial recanalisationNIHSS 0 at 1 month
    Weiner et al 38 15M9R ICA terminusPenumbraY—TICI 3NIHSS 1
    • ICA, internal carotid artery; MCA, middle cerebral artery; mRS, modified Rankin Scale; NA, not applicable; NIHSS, National Institutes of Health Stroke Scale; TICI, thrombolysis in cerebral infarction.

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Mechanical thrombectomy in children and adolescents: report of five cases and literature review
Pervinder Bhogal, Victoria Hellstern, Muhammad AlMatter, Oliver Ganslandt, Hansjörg Bäzner, Marta Aguilar Pérez, Hans Henkes
Stroke and Vascular Neurology Dec 2018, 3 (4) 245-252; DOI: 10.1136/svn-2018-000181

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Mechanical thrombectomy in children and adolescents: report of five cases and literature review
Pervinder Bhogal, Victoria Hellstern, Muhammad AlMatter, Oliver Ganslandt, Hansjörg Bäzner, Marta Aguilar Pérez, Hans Henkes
Stroke and Vascular Neurology Dec 2018, 3 (4) 245-252; DOI: 10.1136/svn-2018-000181
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Mechanical thrombectomy in children and adolescents: report of five cases and literature review
Pervinder Bhogal, Victoria Hellstern, Muhammad AlMatter, Oliver Ganslandt, Hansjörg Bäzner, Marta Aguilar Pérez, Hans Henkes
Stroke and Vascular Neurology Dec 2018, 3 (4) 245-252; DOI: 10.1136/svn-2018-000181
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