Abstract
The treatment approach for patients with internal carotid artery stenosis is receiving increased scrutiny. Major advances in optimal medical therapy have been associated with a declining stroke rate for symptomatic and asymptomatic patients with carotid stenosis. Customising treatment according to gender is worthy of consideration, since earlier clinical trials showed reduced benefit with carotid endarterectomy in women compared to men. In this review, clinical trial results in women are summarised, studies pertaining to carotid plaque imaging in men and women are discussed and new clinical trials are identified. Finally, the rationale for a women's carotid trial is provided.
Footnotes
Contributors EM-L wrote the first draft and contributed to interpretation of data and final approval of the manuscript. SC contributed to critical revision of the manuscript, interpretation of data, conception of work and final approval of the manuscript. EM-L and SC agree to be accountable for all aspects of the work.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
Data sharing statement No additional data are available.
This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
- Article
- Abstract
- Introduction
- Women and asymptomatic carotid disease
- Women and symptomatic carotid disease
- Women and carotid artery stenting
- Timing of carotid revascularisation in women
- Basis of gender differences in carotid disease and revascularisation outcomes
- Clinical trials focused on women
- Conclusions
- Footnotes
- References
- eLetters
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