Differences between thrombus composition and associated clinical data in stroke of different aetiologies
| LAA (n=42) | CE (n=54) | SUE (n=36) | P value | |
| RBC, mean, % (±SD) | 51.19±21.12a | 38.21±15.41b | 33.19±18.22b | <0.001 |
| F+P, mean, % (±SD) | 39.95±19.37a | 55.37±15.19b | 59.04±18.30b | <0.001 |
| WBC, median, % (IQR) | 7.61 (4.36,12.35) | 5.86 (2.85,8.58) | 8.18 (3.62,10.82) | 0.099 |
| CD3, median, cells/mm2 (IQR) | 19.39 (6.45,45.16) | 20.64 (9.12,34.91) | 25.17 (6.08,64.61) | 0.545 |
| NETs, median, % (IQR) | 0.86 (0.18,2.34) | 1.07 (0.17,3.94) | 1.16 (0.32,5.53） | 0.509 |
| IV tPA, n (%) | 15 (35.7) | 21 (38.9) | 18 (50.0) | 0.408 |
| NIHSS score on admission, median (IQR) | 15.5 (10.0,29.0) | 18.0 (13.0,21.0) | 17.5 (13.5,23.75) | 0.461 |
| NIHSS score at discharge, median (IQR) | 9.0 (3.0,33.0) | 12.5 (4.0, 29.75) | 10.5 (5.25,31.0) | 0.691 |
| Occlusion site, ICA/MCA, n (%) | 23(54.8)a | 47 (87.0)b | 25 (69.4)a,b | 0.002 |
| Puncture-to-recanalisation time, median (IQR) | 72.0(53.75,116.75)a | 50.5 (37.0,85.0)b | 53.5 (42.5,83.75)a,b | 0.034 |
| No of manoeuvres, median (IQR) | 2.0 (1.0,2.0) | 2.0 (1.0,2.0) | 2.0 (1.0,3.0) | 0.392 |
| First-pass effect，n (%) | 19 (45.2) | 21 (38.9) | 13 (36.1) | 0.693 |
| Final successful reperfusion (mTICI 2b and 3), n (%) | 38 (90.5) | 51 (94.4) | 32 (88.9) | 0.623 |
| 90-day mRS, median (IQR) | 3.0 (1.0,5.0) | 4.0 (2.0,5.0) | 4.0 (2.0,5.0) | 0.641 |
| 90-day mRS, good prognosis (mRS 0–2), n (%) | 19 (45.2) | 23 (42.6) | 13 (36.1) | 0.706 |
| Mortality within 90 days | 7 (16.7) | 9 (16.7) | 7 (19.4) | 0.932 |
The Bonferroni method was used for multiple comparisons; the same letter indicated no statistical difference between groups and different letters indicated statistical difference between groups. The same letter indicates a significant difference between groups, and the same letter indicates no statistical difference, a/b indicate significant differences between groups. There were significant differences in RBC content (p<0.001) and fibrin/platelet content (p<0.001) between LAA group and CE group. There were significant differences in RBC (p<0.001) and fibrin/platelets (p<0.001) between the LAA group and the SUE group. There was no significant difference in RBC (p=0.201) and fibrin/platelets (p=0.330) between the CE and SUE groups. There was significant difference in time (p=0.032) between the CE and LAA puncture-to-recanalisation time groups.
CE, cardiogenic embolism; F+P, fibrin and platelet; ICA, internal carotid artery; LAA, large artery atherosclerosis; MCA, middle cerebral artery; mRS, modified Rankin scale; mTICI, Thrombolysis in Cerebral Infarction scale; NETs, neutrophil extracellular traps; NIHSS, National Institute of Health Stroke Scale; RBC, red blood cell; SUE, stroke of undetermined aetiology; IV tPA, intravenous tissue plasminogen activator; WBC, white blood cell.