Binary logistic regression analysis of factors influencing onset-to-door time ≤3 hours
| Characteristics | Adjusted OR | 95% CI | P value |
| Urban scale | |||
| Megacity | 1 | ||
| Large city | 0.61 | 0.47 to 0.79 | <0.001 |
| Super-large city | 0.6 | 0.46 to 0.78 | <0.001 |
| Small city | 0.9 | 0.66 to 1.23 | 0.52 |
| Medium-sized city | 0.65 | 0.49 to 0.85 | <0.001 |
| Living with others at the time of illness onset (yes) | 1.2 | 0.98 to 1.46 | 0.07 |
| Patients or family members aware of SEM (yes) | 0.94 | 0.82 to 1.07 | 0.34 |
| AIS classification in TOAST | |||
| Large-artery atherosclerosis | 1 | ||
| Cardiogenic embolism | 0.54 | 0.45 to 0.65 | <0.001 |
| Small-artery occlusion | 1 | 0.9 to 1.11 | 0.99 |
| Stroke of other determined aetiology | 1.05 | 0.84 to 1.31 | 0.68 |
| Stroke of undetermined aetiology | 0.7 | 0.53 to 0.92 | 0.01 |
| Time of stroke onset | |||
| 0:00–5:59 | 1 | ||
| 6:00–11:59 | 0.9 | 0.76 to 1.06 | 0.19 |
| 12:00–17:59 | 0.85 | 0.71 to 1 | 0.06 |
| 18:00–23:59 | 0.72 | 0.6 to 0.86 | <0.001 |
| Distance from onset location to the first-visit hospital | |||
| >20 km | 1 | ||
| ≤20 km | 0.47 | 0.41 to 0.54 | <0.001 |
| Transport to the hospital | |||
| Self-transported to the hospital | 1 | ||
| by EMS | 0.32 | 0.27 to 0.37 | <0.001 |
| Other forms | 0.72 | 0.51 to 1.01 | 0.05 |
| Being transferred between hospitals (yes) | 3.4 | 2.73 to 4.23 | <0.001 |
| Wake-up stroke (yes) | 2.05 | 1.72 to 2.45 | <0.001 |
| Limb weakness (yes) | 0.99 | 0.89 to 1.1 | 0.88 |
| Dizziness/vertigo (yes) | 1.27 | 1.1 to 1.47 | <0.001 |
| Pre-onset mRS score | |||
| 0–1 | 1 | ||
| 2–3 | 1.6 | 1.31 to 1.94 | <0.001 |
| 4–5 | 1.46 | 1 to 2.12 | 0.05 |
| NIHSS score after onset | |||
| 0–4 | 1 | ||
| 5–15 | 0.64 | 0.57 to 0.71 | <0.001 |
| 16–42 | 0.33 | 0.27 to 0.39 | <0.001 |
The factors 211 adjusted for in the multifactorial logistic regression model include age, urban scale, residential 212 status, patient or family awareness of SEM, TOAST classification, time of stroke onset, 213 distance from onset location and first-visit hospital, mode of transportation to the hospital, 214 interhospital transfer, wake-up stroke, limb weakness, dizziness, prestroke mRS score and 215 initial NIHSS score upon hospital arrival.
AIS, acute ischaemic stroke; EMS, emergency medical service; mRS, Modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; SEM, stroke 210 emergency map; TOAST, Trial of Org 10172 in Acute Stroke Treatment.