Comparison of outcome parameters between endovascular therapy alone and bridging therapy
| Outcomes | Endovascular therapy (n=77） | Bridging therapy (n=45） | Treatment effect* (95% CI) | P value |
| Primary outcome | ||||
| mRS score at 90 days | 4 (2–6) | 3 (2–5) | 1.36 (0.71 to 2.61) | 0.35 |
| Secondary outcomes | ||||
| mRS score at 90 days, n (%) | ||||
| 0–2 | 21 (27.3) | 16 (35.6) | 1.30 (0.76 to 2.23) | 0.34 |
| 0–3 | 33 (42.9) | 23 (51.1) | 1.19 (0.81 to 1.75) | 0.38 |
| NIHSS 0–1 or improved ≥10 points at 36 hours, n (%) | 6 (7.8) | 2 (4.4) | 0.57 (0.12 to 2.71) | 0.47 |
| Change from baseline in infarct core volume, mean (SD) | 87.4±91.3 | 111.4±119.5 | 24.02 (−14.09 to 62.13) | 0.21 |
| Target artery recanalisation at 36 hours, n (%) | 60 (90.9) | 32 (86.5) | 0.95 (0.82 to 1.1) | 0.49 |
| Safety outcomes | ||||
| Symptomatic intracranial haemorrhage within 2 days, n (%) | 3 (3.9) | 3 (6.7) | 1.71 (0.36 to 8.12) | 0.50 |
| Any intracranial haemorrhage within 2 days, n (%) | 34 (44.2) | 23 (51.1) | 1.16 (0.79 to 1.69) | 0.46 |
| Death within 90 days, n (%) | 24 (31.2) | 11 (24.4) | 0.75 (0.37 to 1.54) | 0.43 |
| Decompressive hemicraniectomy during hospitalisation, n (%) | 3 (3.9) | 6 (13.3) | 3.42 (0.9 to 13.02) | 0.06 |
*Treatment effects are reported including the primary outcome as a cOR for the ordinal shift on the mRS; the safety outcome of death as an HR; the secondary outcomes of alteration in the volume of infarct core as the mean difference; and the remaining outcomes as the RR.
mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale.