Discriminant indices of the MMSE, MoCA, short-MoCA, SDMT and VasCog Screen
Test | AUC (95% CI) | SEN | SPEC | PPV | NPV | Classification accuracy (%) |
MMSE <27/30 | 0.74 (0.69 to 0.79)† | 0.69 | 0.79 | 0.79 | 0.68 | 73.5 |
MoCA <23/30 | 0.76 (0.71 to 0.81)* | 0.66 | 0.86 | 0.84 | 0.68 | 75.1 |
short-MoCA <9/12 | 0.76 (0.71 to 0.80)† | 0.66 | 0.85 | 0.84 | 0.68 | 74.9 |
SDMT‡ | 0.78 (0.73 to 0.82) | 0.62 | 0.93 | 0.91 | 0.68 | 76.3 |
VasCog Screen | 0.82 (0.78 to 0.86) | 0.85 | 0.80 | 0.83 | 0.82 | 82.4 |
*P<0.05 when AUC was compared with the VasCog Screen
†p<0.001 when AUC was compared with the VasCog Screen
‡According to local norms, impairment in SDMT is defined as <14 and <33 for subjects with primary (≤6) and secondary/tertiary (≥7) years of education, respectively.
AUC, area under the curve; CI, cognitive impairment; MMSE, Mini-Mental State Examination; MoCA, Montreal Cognitive Assessment; NPV, negative predictive value; PPV, positive predictive value; SDMT, Symbol Digit Modalities Test; SEN, sensitivity; SPEC, specificity.