Univariate analysis of the risk of cognitive decline
| Grouping | Cognitive decline | P value | ||
| No | Yes | |||
| Treatment, n (%) | Butylphthalide | 258 (83.5) | 51 (16.5) | 0.022 |
| Control | 225 (76.0) | 71 (24.0) | ||
| Gender, n (%) | Men | 350 (82.2) | 76 (17.8) | 0.028 |
| Women | 133 (74.3) | 46 (25.7) | ||
| Age, mean (SD), y | 61.19 (8.59) | 64.19 (7.63) | < 0.001 | |
| Age group, n (%) | < 60 years | 200 (84.7) | 36 (15.3) | 0.016 |
| ≥ 60 years | 283 (76.7) | 86 (23.3) | ||
| Education years, mean (SD), y | 7.42 (3.40) | 6.17 (3.47) | < 0.001 | |
| Educational level, n (%) | 0 years | 23 (65.7) | 12 (34.3) | 0.007 |
| 1~6 years | 178 (76.1) | 56 (23.9) | ||
| > 6 years | 282 (83.9) | 54 (16.1) | ||
| Smoking status, n (%) | Never | 176 (74.9) | 59 (25.1) | 0.013 |
| Former | 198 (85.7) | 33 (14.3) | ||
| Current | 109 (78.4) | 30 (21.6) | ||
| Alcohol use, n (%) | Never | 202 (75.1) | 67 (24.9) | 0.034 |
| Former | 197 (83.8) | 38 (16.2) | ||
| Current | 84 (83.2) | 17 (16.8) | ||
| CHD, n (%) | No | 429 (80.3) | 105 (19.7) | 0.398 |
| Yes | 54 (76.1) | 17 (23.9) | ||
| BMI, mean (SD), kg/m2 | 26.85 (3.50) | 26.41 (3.24) | 0.216 | |
| BMI category, n (%) | Thin | 2 (100.0) | 0 (0.0) | 0.476 |
| Normal | 99 (80.5) | 24 (19.5) | ||
| Overweight | 216 (77.4) | 63 (22.6) | ||
| Obese | 166 (82.6) | 35 (17.4) | ||
| SBP, mean (SD), mmHg | 152.33 (20.72) | 155.06 (18.82) | 0.205 | |
| FBG, mean (SD), mmol/L | 6.78 (2.18) | 6.98 (2.38) | 0.381 | |
| TC, mean (SD), mmol/L | 4.37 (1.09) | 4.45 (1.07) | 0.464 | |
| TG, mean (SD), mmol/L | 1.60 (1.20) | 1.51 (1.06) | 0.439 | |
| HDL-C, mean (SD), mmol/L | 1.21 (0.28) | 1.27 (0.29) | 0.028 | |
CHD, coronary heart disease; FBG, fasting blood glucose; HDL-C, high-density lipoprotein cholesterol; SBP, systolic blood pressure; TC, total cholesterol; TG, triglyceride .