Clinical characteristics of patients
| Clinical characteristics | Training set (n=325) | Test set (n=139) | External validation set (n=100) |
| Age (mean, IQR) | 65.2 (7.3) | 62.9 (8.1) | 67.0 (9.0) |
| Sex (male, %) | 156 (48.0) | 74 (53.2) | 40 (41.0) |
| Vascular risk factors | |||
| Hypertension* (n, %) | 181 (58.6) | 71 (51.1) | 46 (46.0) |
| Diabetes *(n, %) | 65 (20.0) | 14 (11.5) | 12 (12.0) |
| Hyperlipidaemia* (n, %) | 53 (16.3) | 37 (26.7) | 19 (19.0) |
| Carotid plaque †(n, %) | 129 (39.7) | 69 (49.6) | 40 (40.0) |
| Smoke (n, %) | 105 (32.3) | 41 (29.5) | 28 (28.0) |
| White matter hyperintensity | |||
| Fazekas score | 2.7 (1.9) | 2.6 (1.7) | 2.1 (1.1) |
| WMH volume (mm3) | 2247.6 (2850.9) | 2024.2 (2914.3) | 1831.5 (2247.4) |
| CHIPS score (manual) | 15.4 (24.0) | 14.0 (25.3) | 12.8 (17.3) |
| CHIPS score (intelligent algorithm) | 16.1 (32.0) | 15.0 (27.8) | 13.1 (20.2) |
*Depend on self-reported.
†Diagnosis by carotid artery ultrasound.
‡
§
CHIPSC, Cholinergic Pathways Hyperintensities Scale ; WMH, white matter hyperintensities.