Proportion and prediction of missing data for clinical outcomes assessed at 12 months in the LACI-2 trial based on key baseline variables
| Outcome | Participants where outcome is missing (%) | Baseline predictors as covariates in models to predict missingness | ||||||
| Age | Baseline MoCA | Sex | Prestroke mRS | NIHSS | Time to randomisation | Education | ||
| Cog 7 Level | 55 (15.15%) | *−0.038 (0.018) | −0.185 (<0.0001) | 0.721 (0.064) | *Overall (0.006) | −0.258 (0.057) | 0.0002 (0.208) | Overall (0.257) |
| Cog 4 Level | 55 (15.15%) | *−0.040 (0.018) | −0.185 (<0.0001) | 0.721 (0.064) | *Overall (0.006) | −0.258 (0.057) | 0.0002 (0.208) | Overall (0.257) |
| Modified Rankin Scale | 40 (11.02%) | *−0.036 (0.045) | −0.010 (0.849) | 0.021 (0.958) | Overall (0.083) | −0.187 (0.008) | −0.001 (0.272) | *Overall (0.015) |
| t-MoCA | 56 (15.43%) | *0.036 (0.023) | *0.187 (<0.0001) | −0.585 (0.123) | *Overall (0.017) | 0.188 (0.145) | −0.0004 0.168) | Overall (0.364) |
| TICS-m | 50 (13.77%) | *0.041 (0.012) | *0.205 (<0.0001) | −0.547 (0.166) | *Overall (0.036) | 0.343 (0.018) | 0.0002 (0.669) | Overall (0.536) |
| Verbal fluency test | 44 (12.12%) | −0.033 (0.056) | −0.189 (0.0001) | 0.495 (0.226) | Overall (0.051) | *−0.313 (0.036) | −0.0001 (0.762) | Overall (0.620) |
| Trail Making Test B† | 207 (57.02%) | 0.003 (0.821) | 0.0001 (0.999) | −0.099 (0.684) | Overall (0.164) | 0.137 (0.136) | 0.0002 (0.506) | Overall (0.146) |
| Zung depression scale | 46 (12.67%) | *−0.034 (0.040) | −0.063 (0.206) | −0.017 (0.963) | Overall (0.087) | −0.190 (0.159) | −0.0004 (0.378) | Overall (0.092) |
| Care home placement‡ | 42 (11.57%) | *−0.043 (0.013) | −0.035 (0.506) | 0.098 (0.802) | Overall (0.067) | −0.175 (0.212) | −0.0006 (0.250) | *Overall (0.031) |
| IQCODE§ | 205 (56.47%) | *−0.023 (0.041) | 0.002 (0.958) | 0.115 (0.634) | Overall (0.116) | 0.097 (0.280) | −0.0006 (0.019) | Overall (0.693) |
| EQ-5D-5L¶ | 43 (11.85%) | *−0.045 (0.010) | −0.055 (0.289) | −0.005 (0.990) | Overall (0.093) | −0.166 (0.227) | −0.0004 (0.380) | *Overall (0.034) |
| EQVAS¶ | 43 (11.85%) | *−0.045 (0.010) | −0.055 (0.289) | −0.005 (0.990) | Overall (0.093) | −0.166 (0.227) | −0.0004 (0.380) | *Overall (0.034) |
Each row corresponds to a model using column variables as predictors.
Systolic BP and smoking did not predict missing variables (data not shown).
*estimate (p value)*=overall significant predictor variable.
†Required in-person assessment; many participants were unable to attend for assessment due to COVID-19 regulations.
‡Disposition that is, place of residence, at 12 months. A: home independent—267, H: home with carer—49, R: residential home—1, died—4, missing and null—11+35=46–4=42.
§IQCODE: information collected from a person who knows the participant well; 213 participants did not provide informant details at randomisation, 7 participants had IQCODE but no informant recorded, 1 participant had informant but IQCODE not computed due to missing values.
¶EQ-5D-5L and EQVAS—measures of quality of life.
DSM-5, Diagnostic and Statistical Manual of Mental Disorders Fifth Edition; NIHSS, National Institutes of Health Stroke Scale.