Outcomes of adjusted models in unmatched groups and PSM groups (sensitivity analysis)
| Outcome | Unmatched groups | Model 1 | Model 2 | Model 3 | ||
| TNK | Alteplase | P value | aOR (95% CI), Adj. P value | aOR (95% CI), Adj. P value | aOR (95% CI), Adj. P value | |
| Primary outcome | ||||||
| sICH | 20/1113 (1.8%) | 55/2360 (2.33%) | 0.313 | 0.98 (0.57–1.71), 0.964 | 0.96 (0.55, 1.66), 0.875 | 1.09 (0.61–1.95), 0.766 |
| Secondary outcome | ||||||
| Safety profile | ||||||
| Any intracranial bleeding | 23/1113 (2.07%) | 109/2360 (4.62%) | 0.000 | 0.49 (0.31– 0.79), 0.003 | 0.47 (0.29–0.75), 0.002 | 0.65 (0.40–1.06), 0.085 |
| PH2 | 15/1113 (1.35%) | 41/2360 (1.74%) | 0.396 | 0.99 (0.52–1.86), 0.966 | 0.99 (0.52–1.86), 0.971 | 1.21 (0.64–2.28), 0.561 |
| Any systemic bleeding | 5/1113 (0.45%) | 3/2360 (0.13%) | 0.065 | 2.48 (0.51–12.07), 0.259 | 2.47 (0.52–11.86), 0.258 | 4.13 (0.85–20.09), 0.079 |
| Death within 90 days | 68/1094 (6.22%) | 181/2208 (8.2%) | 0.042 | 0.92 (0.66–1.29), 0.636 | 0.94 (0.67–1.31), 0.703 | 1.06 (0.74–1.52), 0.75 |
| Efficacy | ||||||
| 24-hour NIHSS score improvement ≥4 OR ≤1 | 637/1108 (57.49%) | 953/2324 (41.01%) | 0.000 | 1.72 (1.48–2.01), 0.000 | 1.81 (1.54–2.11), 0.000 | 1.12 (0.93–1.35), 0.22 |
| mRS at 90 days | 0 (0-2) N=1094 | 1（0-3） N=2208 | 0.000 | 0.64 (0.55, 0.74), 0.000 | 0.65 (0.56–0.76), 0.000 | 1.11 (0.94–1.32), 0.216 |
| mRS=0–1 at 90 days | 788（72.03%） | 1417 (64.18%) | 0.000 | 1.31 (1.09–1.59), 0.005 | 1.30 (1.07–1.58), 0.008 | 0.82 (0.66–1.02), 0.073 |
| mRS=0–2 at 90 days | 885 (80.90%) | 1625 (73.6%) | 0.000 | 1.47 (1.19–1.81), 0.000 | 1.47 (1.18–1.82), 0.001 | 0.96 (0.76–1.21), 0.726 |
Model 1: Unmatched cohort adjusts for age, sex, smoking, pre-mRS, NIHSS, glucose at emergency, SBP at emergency, bridging with thrombectomy, diabetes, dyslipidemia, atrial fibrillation, heart failure, ischaemic stroke/TIA, taking antiplatelet drugs.
Model 2: Unmatched cohort adjusts for variables in model 1 combined with onset-to-treatment (OTT) time.
Model 3: Unmatched cohort excludes data from the Inner Mongolia centre, and adjusts for variables in model 1.
mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; PH2, parenchymal haemorrhage type 2; PSM, propensity score matching; SBP, systolic blood pressure.